Product image of Letrozol Ratiopharm (Letrozole) supplied by GNH India

Letrozol Ratiopharm

Active Ingredient:
Letrozole
Origin:
EU

Letrozol Ratiopharm (Letrozole)

Letrozole, the active ingredient in Letrozol Ratiopharm, is an aromatase inhibitor presented as an oral tablet for oral use. It is employed to treat hormone receptor‑positive breast cancer in postmenopausal women by lowering estrogen levels that can stimulate tumor growth.

GNH India supplies Letrozol Ratiopharm as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Teva B.V

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Indications & Clinical Uses

Letrozole acts on the estrogen synthesis pathway and is used in the management of hormone‑dependent breast cancer.

  • Hormone receptor‑positive metastatic breast cancer in postmenopausal women: reduces estrogen production to inhibit tumor progression.
  • Early‑stage hormone receptor‑positive breast cancer (adjuvant setting) in postmenopausal women: lowers recurrence risk after surgery.
  • Extended adjuvant therapy after 5 years of tamoxifen in postmenopausal women: provides continued estrogen suppression to prevent disease return.

How It Works

  • Letrozole selectively and reversibly inhibits the aromatase enzyme, which converts androgens to estrogens. By blocking this conversion, systemic estrogen concentrations fall, depriving estrogen‑dependent tumor cells of a growth stimulus and thereby slowing or halting cancer progression.

Side Effects

Letrozole may cause a range of adverse reactions, most of which are mild to moderate.

Common Side Effects

  • Hot flashes
  • Joint and muscle pain
  • Fatigue
  • Nausea
  • Headache
  • Increased sweating

Serious or Rare Side Effects

  • Osteoporosis or bone fractures
  • Severe liver injury
  • Pulmonary embolism or deep‑vein thrombosis
  • Anaphylactic or severe allergic reactions
  • Elevated cholesterol levels

Precautions & Warnings

Before initiating therapy, clinicians should assess individual risk factors and monitor patients regularly.

  • Pregnancy contraindication: avoid use in pregnant women; Letrozole is classified as Category X.
  • Bone health monitoring: assess bone mineral density periodically.
  • Liver function: check hepatic enzymes before and during treatment.
  • Lipid profile: monitor cholesterol levels regularly.
  • Premenopausal status: do not use in premenopausal women unless ovarian suppression is confirmed.
  • Store at ambient temperature: keep in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Letrozole can interact with several medicines, influencing its efficacy or safety.

Major Interactions (Avoid)

  • Estrogen replacement therapy: may counteract Letrozole’s effect.
  • Strong CYP2C19 inhibitors (e.g., ketoconazole): can increase Letrozole plasma levels.
  • Strong CYP3A4 inducers (e.g., rifampin): may reduce Letrozole exposure.

Moderate Interactions (Monitor Closely)

  • Warfarin: may enhance anticoagulant effect.
  • Tamoxifen: concurrent use may affect hormonal balance.
  • Selective serotonin reuptake inhibitors (e.g., paroxetine): potential CYP2D6 interaction.
  • Statins: monitor lipid changes.
  • Glucocorticoids: observe for additive bone‑loss risk.

Frequently Asked Questions

Letrozol Ratiopharm contains letrozole, an aromatase inhibitor used to treat hormone receptor‑positive breast cancer in postmenopausal women, both in metastatic and adjuvant settings.

Letrozole blocks the aromatase enzyme, preventing the conversion of androgens to estrogen. This reduces circulating estrogen levels, limiting the growth stimulus for estrogen‑dependent breast cancer cells.

The prescribed dose of letrozole is determined by the treating physician based on the patient’s condition, clinical guidelines, and individual factors. Patients should follow the prescriber’s instructions exactly.

Letrozole is classified as Pregnancy Category X and is contraindicated in pregnancy. It is also not recommended for breastfeeding women because it may pass into breast milk and affect the infant.

To order, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and import documentation.

Letrozole belongs to the aromatase‑inhibitor class, which directly lowers estrogen production, unlike selective estrogen receptor modulators such as tamoxifen that block estrogen receptors. In postmenopausal patients, aromatase inhibitors often provide superior disease‑free survival in clinical trials.

Letrozol Ratiopharm should be stored at ambient temperature, below 25 °C, in its original packaging, protected from moisture and direct sunlight to maintain stability.

The medication is taken orally, usually as a tablet, with or without food, according to the dose prescribed by the healthcare professional.

Serious risks include osteoporosis or bone fractures, severe liver injury, pulmonary embolism, and rare allergic reactions. Patients should be monitored regularly for these potential complications.

Letrozol Ratiopharm should not be used by pregnant women, premenopausal women without ovarian suppression, patients with severe liver impairment, or anyone with known hypersensitivity to letrozole or its excipients.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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