Product image of Letrozol Stada (Letrozole) supplied by GNH India

Letrozol Stada

Active Ingredient:
Letrozole
Origin:
EU

Letrozol Stada (Letrozole)

Letrozole, the active ingredient in Letrozol Stada, is an aromatase inhibitor presented as an oral tablet for oral use. It is indicated for the treatment of hormone‑receptor positive breast cancer in postmenopausal women, both in the adjuvant and metastatic settings. GNH India supplies Letrozol Stada as a licensed, GDP‑compliant international pharmaceutical supplier serving oncology centres, hospitals and pharmacies worldwide.

Manufacturer / TM Owner

Stada Arzneimittel Gmbh

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Indications & Clinical Uses

Letrozol Stada is an aromatase inhibitor used in the endocrine therapy of breast cancer.

  • Early‑stage hormone‑receptor positive breast cancer: reduces the risk of disease recurrence when given as adjuvant therapy.
  • Metastatic hormone‑receptor positive breast cancer: helps control tumor growth and prolongs survival in postmenopausal patients.
  • Hormone‑receptor positive breast cancer after surgery: used as part of postoperative systemic treatment to lower estrogen‑driven cancer progression.

How It Works

  • Letrozole reversibly binds to the aromatase enzyme, blocking the conversion of androgens to estrogens in peripheral tissues. By inhibiting aromatase, systemic estrogen levels fall, depriving estrogen‑dependent breast cancer cells of a growth stimulus, which slows tumor proliferation and may induce apoptosis.

Side Effects

Letrozol Stada may cause a range of adverse reactions.

Common Side Effects

  • Hot flashes: sudden feeling of warmth, often with sweating.
  • Joint and muscle pain: aching or stiffness in limbs.
  • Fatigue: persistent tiredness not relieved by rest.
  • Nausea or mild gastrointestinal upset.

Serious or Rare Side Effects

  • Severe liver injury: jaundice, elevated liver enzymes, or hepatic failure.
  • Bone fractures: increased risk of osteoporosis‑related fractures.
  • Thromboembolic events: deep‑vein thrombosis or pulmonary embolism.
  • Severe allergic reactions: rash, swelling, or anaphylaxis.

Precautions & Warnings

Before initiating Letrozol Stada, several safety considerations are recommended.

  • Monitor bone health: assess baseline bone mineral density and consider calcium/vitamin D supplementation.
  • Assess liver function: obtain baseline liver enzymes and repeat periodically.
  • Evaluate cardiovascular risk: screen for history of thrombosis or clotting disorders.
  • Contraindicated in pregnancy: avoid use in women who are or may become pregnant.
  • Use caution with concomitant estrogen therapy: may reduce drug efficacy.
  • Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Letrozol Stada can interact with several medicines, requiring attention to avoid reduced efficacy or increased toxicity.

Major Interactions (Avoid)

  • Estrogen replacement therapy: antagonizes aromatase inhibition and diminishes therapeutic effect.
  • Strong CYP3A4 inducers (e.g., rifampin, carbamazepine): may lower plasma concentrations of letrozole.

Moderate Interactions (Monitor Closely)

  • Tamoxifen: concurrent use may interfere with hormonal pathways; monitor clinical response.
  • Warfarin: letrozole may alter INR; check coagulation status regularly.
  • Certain SSRIs (e.g., fluoxetine): may affect metabolism; observe for increased side effects.

Frequently Asked Questions

Letrozol Stada is an oral formulation of letrozole, an aromatase inhibitor indicated for the treatment of hormone‑receptor positive breast cancer in postmenopausal women. It is used in both early‑stage (adjuvant) and metastatic disease to lower estrogen levels and help control tumor growth.

Letrozole blocks the aromatase enzyme, which converts androgens into estrogens in peripheral tissues. By inhibiting this conversion, systemic estrogen concentrations fall, depriving estrogen‑dependent breast cancer cells of a key growth signal, thereby slowing proliferation and potentially inducing cell death.

The prescribed dose of Letrozol Stada is determined by the treating physician based on the patient’s clinical condition. In many treatment protocols, a common starting dose is 2.5 mg taken once daily, but the exact regimen should always follow the prescriber’s instructions.

Letrozol Stada is classified as Pregnancy Category X, meaning it is contraindicated in pregnant women because it can cause fetal harm. It is also not recommended for breastfeeding mothers, as it may pass into breast milk and affect the infant.

To request Letrozol Stada, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain needs) and required import documentation.

Letrozole is a non‑steroidal aromatase inhibitor, similar to anastrozole but generally considered more potent on a milligram‑per‑milligram basis. Unlike the steroidal inhibitor exemestane, letrozole binds reversibly to aromatase. All three lower estrogen levels, but differences in potency, side‑effect profile and drug‑interaction potential may influence the choice of therapy.

Letrozol Stada should be stored at ambient temperature, preferably below 25 °C. Keep the tablets in the original blister pack or container, protect them from moisture, heat and direct sunlight, and ensure the packaging remains tightly closed until use.

Letrozol Stada is taken orally, usually as a single tablet swallowed whole with a glass of water. It can be taken with or without food, but consistency in relation to meals helps maintain stable drug levels. Patients should follow the dosing schedule prescribed by their healthcare provider.

The most serious risks include severe liver injury, significant bone loss leading to fractures, and thromboembolic events such as deep‑vein thrombosis or pulmonary embolism. Rarely, life‑threatening allergic reactions may occur. Patients should be monitored regularly for signs of these conditions and report any concerning symptoms promptly.

Letrozol Stada is contraindicated in premenopausal women, pregnant or breastfeeding individuals, and patients with known hypersensitivity to letrozole or any tablet excipients. It should also be avoided in patients with severe hepatic impairment unless the prescriber determines that benefits outweigh the risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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