Product image of Letrozol Stada (Letrozole) supplied by GNH India

Letrozol Stada

Active Ingredient:
Letrozole
Origin:
EU

Letrozol Stada (Letrozole)

Letrozole, the active ingredient in Letrozol Stada, is an aromatase inhibitor presented as an oral tablet for oral use. It is employed in the treatment of postmenopausal estrogen receptor‑positive breast cancer, reducing estrogen production that can drive tumor growth.

GNH India supplies Letrozol Stada as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres and pharmacies worldwide. The company adheres to stringent quality standards and provides regulatory documentation to support import and distribution across multiple regions. Customers benefit from reliable lead times and comprehensive technical support.

Manufacturer / TM Owner

Stadapharm Gmbh

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Indications & Clinical Uses

Letrozole is used in endocrine therapy targeting estrogen‑dependent breast cancer pathways.

  • Postmenopausal estrogen receptor‑positive breast cancer: reduces risk of disease recurrence and progression.
  • Adjuvant therapy for early‑stage ER+ breast cancer: helps prevent cancer return after surgery.
  • Metastatic ER+ breast cancer: slows tumor growth in advanced disease.

How It Works

  • Letrozole reversibly binds to the aromatase enzyme, a cytochrome P450 isoform responsible for converting androstenedione and testosterone to estrone and estradiol. By inhibiting this conversion, systemic estrogen levels fall markedly, depriving estrogen‑dependent tumor cells of a growth stimulus and thereby limiting proliferation of hormone‑sensitive breast cancer. The inhibition is dose‑dependent and persists for several days after the last dose, allowing sustained estrogen suppression without the need for continuous dosing adjustments.

Side Effects

Letrozole may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Hot flashes: sudden warmth and sweating.
  • Joint pain: aches in joints or muscles.
  • Fatigue: persistent tiredness.
  • Nausea: upset stomach and urge to vomit.

Serious or Rare Side Effects

  • Severe liver injury: marked elevation of liver enzymes or hepatitis.
  • Bone fractures: increased risk of osteoporosis‑related breaks.
  • Pulmonary embolism: blood clot in lung vessels.

Precautions & Warnings

When prescribing Letrozol Stada, clinicians should consider several safety measures.

  • Monitor liver function: perform baseline and periodic liver enzyme tests.
  • Assess bone health: evaluate bone mineral density and consider calcium/vitamin D supplementation.
  • Use only in postmenopausal women: drug is not indicated for premenopausal patients.
  • Review concomitant medications: check for drugs affecting CYP2A6 metabolism.
  • Contraindicated in pregnancy and lactation: discuss risks with prescriber.
  • Store at ambient temperature below 25°C: keep in the original packaging, protect from moisture.

Avoid Interactions

Letrozol Stada can interact with other medicines, requiring careful management.

Major Interactions (Avoid)

  • Concurrent estrogen replacement therapy: may diminish letrozole’s efficacy.
  • Strong CYP2A6 inhibitors (e.g., fluvoxamine): increase letrozole plasma concentrations.
  • Strong CYP2A6 inducers (e.g., rifampicin): reduce letrozole exposure.

Moderate Interactions (Monitor Closely)

  • Tamoxifen: potential antagonistic effect; monitor therapeutic response.
  • Warfarin: possible alteration of INR; check coagulation parameters regularly.

Frequently Asked Questions

Letrozol Stada contains letrozole, an aromatase inhibitor indicated for the treatment of postmenopausal estrogen receptor‑positive breast cancer. It is used to lower estrogen levels, thereby slowing the growth of hormone‑sensitive tumors in both early‑stage and metastatic settings.

Letrozole blocks the aromatase enzyme, which converts adrenal androgens into estrogen. By inhibiting this conversion, circulating estrogen concentrations drop, depriving estrogen‑dependent breast cancer cells of a key growth signal and limiting tumor proliferation.

The specific dose of Letrozol Stada is determined by the prescribing physician based on the patient’s clinical condition, treatment stage, and individual factors. Healthcare professionals follow approved guidelines and adjust the regimen as needed for safety and efficacy.

Letrozol Stada is contraindicated in pregnancy and breastfeeding because it can interfere with estrogen production essential for fetal development and lactation. Women of child‑bearing potential should use effective contraception and discuss any pregnancy plans with their healthcare provider.

To request Letrozol Stada, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Letrozol Stada (letrozole) is a third‑generation aromatase inhibitor with a high potency and a long half‑life, offering sustained estrogen suppression. Compared with earlier agents such as anastrozole, letrozole often provides slightly greater estrogen reduction, though individual response and tolerability can vary, so choice is guided by clinical judgment.

Letrozol Stada tablets should be stored at ambient temperature below 25 °C, protected from moisture and light. Keep the medication in its original container until use, and avoid exposing it to excessive heat or humidity to maintain potency.

Letrozol Stada is taken orally, usually as a single tablet swallowed with water. The exact timing (e.g., with or without food) follows the prescriber’s instructions, and patients should adhere to the dosing schedule set by their healthcare professional.

Serious risks include severe liver injury, bone fractures due to decreased estrogen, and rare events such as pulmonary embolism. Patients should report signs of jaundice, unexplained bone pain, or sudden shortness of breath to their physician promptly.

Letrozol Stada should not be used by premenopausal women, pregnant or nursing individuals, and patients with known hypersensitivity to letrozole or any tablet excipients. It is also avoided in patients with severe liver impairment unless specifically directed by a specialist.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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