Product image of Letrozol Stada (Letrozole) supplied by GNH India

Letrozol Stada

Active Ingredient:
Letrozole
Origin:
EU

Letrozol Stada (Letrozole)

Letrozole, the active ingredient in Letrozol Stada, is an aromatase inhibitor presented as a tablet for oral use. It works by reducing estrogen production and is indicated for hormone‑positive breast cancer in postmenopausal women, helping to slow tumor growth and improve clinical outcomes.

GNH India supplies Letrozol Stada as a licensed, GDP‑compliant international pharmaceutical supplier serving oncology centres, hospitals and pharmacies worldwide.

Manufacturer / TM Owner

Stada Lda.

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Indications & Clinical Uses

  • Letrozol Stada is an aromatase inhibitor used in the management of hormone‑driven breast cancer.
  • Hormone receptor‑positive breast cancer in postmenopausal women: reduces estrogen‑driven tumor proliferation.
  • Adjuvant therapy for early‑stage disease: lowers risk of recurrence after surgery.
  • Metastatic breast cancer in postmenopausal women: helps control disease progression.

How It Works

  • Letrozole reversibly binds to the aromatase enzyme, inhibiting its activity. By blocking the conversion of androgens to estrogens, systemic estrogen levels fall, depriving estrogen‑dependent tumor cells of a growth stimulus and thereby limiting cancer progression in hormone‑sensitive breast tumors.

Side Effects

Letrozol Stada may cause a range of adverse reactions.

Common Side Effects

  • Hot flashes: sudden feeling of warmth and sweating.
  • Joint and muscle pain: aching in joints or muscles.
  • Fatigue: persistent tiredness.
  • Nausea: upset stomach or urge to vomit.

Serious or Rare Side Effects

  • Severe liver injury: jaundice, elevated liver enzymes.
  • Bone fracture: increased risk of osteoporosis‑related breaks.
  • Pulmonary embolism: sudden shortness of breath or chest pain.
  • Allergic reaction: rash, itching, swelling, or difficulty breathing.
  • Elevated cholesterol: changes in lipid profile.

Precautions & Warnings

  • Before initiating Letrozol Stada, clinicians should consider several safety measures.
  • Monitor bone mineral density: assess risk of osteoporosis and consider supplementation.
  • Assess liver function: check enzymes prior to therapy and periodically during treatment.
  • Evaluate cardiovascular risk: review history of thromboembolic events.
  • Avoid use in pregnancy: Letrozole is contraindicated and teratogenic.
  • Store at ambient temperature (below 25 °C): keep in the original pack, protect from moisture.

Avoid Interactions

Letrozol Stada can interact with other medicines, requiring careful management.

Major Interactions (Avoid)

  • Estrogen‑containing hormone replacement therapy: reduces Letrozole efficacy.
  • Strong CYP2A6 inhibitors (e.g., ketoconazole): may increase Letrozole plasma levels.
  • Potent CYP3A4 inducers (e.g., rifampin): may lower Letrozole concentrations.

Moderate Interactions (Monitor Closely)

  • Tamoxifen: potential antagonistic effect on estrogen pathways.
  • Warfarin: Letrozole may alter INR values.
  • Selective serotonin reuptake inhibitors (SSRIs): possible effect on drug metabolism.

Frequently Asked Questions

Letrozol Stada contains letrozole, an aromatase inhibitor indicated for the treatment of hormone‑positive breast cancer in postmenopausal women. It is used in both early‑stage (adjuvant) and metastatic settings to reduce estrogen‑driven tumor growth.

Letrozole blocks the aromatase enzyme, which converts androgens into estrogens. By inhibiting this conversion, systemic estrogen levels fall, depriving estrogen‑dependent breast cancer cells of a key growth signal and thereby slowing disease progression.

The prescribed dose of Letrozol Stada is determined by the treating physician based on the patient’s clinical condition, renal and hepatic function, and treatment guidelines. Dosage instructions are not provided here and should follow the prescriber’s order.

Letrozole is classified as pregnancy category X, meaning it is contraindicated in pregnancy because it can cause fetal harm. It is also not recommended during breastfeeding, as it may pass into breast milk and affect the infant.

To order Letrozol Stada, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Letrozol Stada (letrozole) is a third‑generation aromatase inhibitor with a long half‑life, offering once‑daily dosing. Compared with anastrozole or exemestane, letrozole generally provides slightly higher estrogen suppression, which may translate into modest differences in efficacy for certain patient populations.

Letrozol Stada tablets should be stored at ambient temperature, below 25 °C, in the original container to protect from moisture and light. Keep the product out of reach of children and do not use after the expiry date.

Letrozol Stada is taken orally, usually as a whole tablet with water. It is typically taken once daily, with or without food, as directed by the prescribing clinician.

Serious risks include severe liver injury, osteoporosis leading to fractures, and rare thromboembolic events such as pulmonary embolism. Patients should be monitored regularly for liver function, bone health, and signs of clotting disorders.

Letrozol Stada should not be used by pregnant women, nursing mothers, or patients with known hypersensitivity to letrozole or any excipients. It is also contraindicated in individuals with severe liver impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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