Product image of Letrozol Stada (Letrozole) supplied by GNH India

Letrozol Stada

Active Ingredient:
Letrozole
Origin:
EU

Letrozol Stada (Letrozole)

Letrozole, the active ingredient in Letrozol Stada, is an aromatase inhibitor presented as a tablet for oral use. It treats hormone receptor‑positive breast cancer in postmenopausal women and is marketed in the European Union as a prescription‑only product.

GNH India supplies Letrozol Stada as a licensed, GDP‑compliant international pharmaceutical supplier serving oncology centres worldwide. The company provides bulk and finished‑product solutions to hospitals, oncology centres, pharmacies, research institutions and procurement teams across multiple continents.

Manufacturer / TM Owner

Stada Arzneimittel Ag

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Indications & Clinical Uses

Letrozole is an aromatase inhibitor used in the management of hormone‑dependent breast cancer.

  • Hormone receptor‑positive breast cancer in postmenopausal women: reduces tumor growth by lowering estrogen levels.
  • Adjuvant treatment of early‑stage breast cancer: prolongs disease‑free survival after surgery.
  • Metastatic breast cancer: improves progression‑free survival in advanced disease.

How It Works

  • Letrozole selectively inhibits the aromatase enzyme, which converts adrenal and ovarian androgens into estrogens. By blocking this conversion, systemic estrogen concentrations fall, decreasing stimulation of estrogen‑dependent tumor cells and slowing the proliferation of hormone‑sensitive breast cancer.

Side Effects

Letrozole may cause a range of adverse reactions.

Common Side Effects

  • Hot flashes
  • Joint pain (arthralgia)
  • Nausea
  • Fatigue

Serious or Rare Side Effects

  • Severe liver injury
  • Bone fracture due to decreased bone density
  • Deep vein thrombosis or pulmonary embolism
  • Severe allergic reaction (anaphylaxis)

Precautions & Warnings

When prescribing Letrozole, clinicians should consider several safety measures.

  • Monitor liver function: perform baseline and periodic liver‑function tests.
  • Assess bone health: consider prophylactic calcium and vitamin D supplementation.
  • Evaluate cardiovascular risk: monitor lipid profile regularly.
  • Avoid use in pregnancy: contraindicated in women of childbearing potential.
  • Adjust in severe renal impairment: use with caution and monitor renal parameters.
  • Store at ambient temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Letrozole can interact with other medicines, requiring attention to avoid reduced efficacy or increased toxicity.

Major Interactions (Avoid)

  • Strong CYP3A4 inducers (e.g., rifampin) may markedly lower letrozole levels.
  • Tamoxifen may antagonize letrozole’s therapeutic effect.

Moderate Interactions (Monitor Closely)

  • Anticoagulants such as warfarin may increase INR.
  • Selective serotonin reuptake inhibitors (e.g., fluoxetine) can raise plasma concentrations.
  • Statins may have altered metabolism when co‑administered.

Frequently Asked Questions

Letrozol Stada contains letrozole, an aromatase inhibitor indicated for the treatment of hormone receptor‑positive breast cancer in postmenopausal women, including adjuvant and metastatic settings.

Letrozole blocks the aromatase enzyme, preventing the conversion of androgens to estrogens. This reduction in estrogen levels limits the growth stimulus for estrogen‑dependent breast cancer cells.

The specific dose and regimen of letrozole are determined by the prescribing physician based on the patient’s clinical condition and treatment guidelines.

Letrozole is contraindicated in pregnancy and its safety during breastfeeding is unknown; it should not be used by women who are pregnant, may become pregnant, or are nursing.

Enquiries can be submitted on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and import documentation.

Letrozole, as an aromatase inhibitor, offers a different mechanism than selective estrogen receptor modulators such as tamoxifen. It is often preferred in postmenopausal patients for its efficacy in lowering estrogen levels and improving disease‑free survival.

Store Letrozol Stada at ambient temperature, below 25 °C, in the original packaging, protected from moisture and light to maintain product stability.

Letrozol Stada is taken orally, usually as a tablet, with or without food, as directed by the prescribing healthcare professional.

Serious risks include severe liver injury, bone fractures due to decreased bone density, and thromboembolic events such as deep‑vein thrombosis or pulmonary embolism, which require prompt medical attention.

Letrozole should not be used by pregnant women, individuals who may become pregnant, or patients with known hypersensitivity to letrozole or any component of the formulation.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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