Product image of Letrozol Synthon (Letrozole) supplied by GNH India

Letrozol Synthon

Active Ingredient:
Letrozole
Origin:
EU

Letrozol Synthon (Letrozole)

Letrozole, the active ingredient in Letrozol Synthon, is an aromatase inhibitor presented as a tablet for oral use. It is used in the treatment of hormone receptor‑positive breast cancer in postmenopausal women and in metastatic breast cancer.
GNH India supplies Letrozol Synthon as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Synthon Bv

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Indications & Clinical Uses

Letrozole is an aromatase inhibitor used in breast cancer therapy, acting on estrogen‑dependent pathways.

  • Hormone receptor‑positive early breast cancer (adjuvant): reduces recurrence risk after surgery.
  • Metastatic hormone receptor‑positive breast cancer (first‑line): slows disease progression in postmenopausal women.
  • Recurrent hormone receptor‑positive breast cancer: provides disease control after prior therapy.

How It Works

  • Letrozole reversibly binds to the aromatase enzyme, a cytochrome P450 isoform responsible for converting androgens to estrogens. By inhibiting this non‑steroidal enzyme, estrogen synthesis is markedly reduced, leading to lower circulating estradiol levels and diminished estrogen‑driven tumor growth in hormone‑sensitive breast cancer.

Side Effects

Letrozole may cause a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Hot flashes: sudden feeling of warmth and sweating.
  • Joint and muscle pain: aching in joints or muscles.
  • Fatigue: persistent tiredness.
  • Nausea: mild to moderate upset stomach.
  • Headache: pressure or throbbing pain.
  • Dizziness: light‑headed sensation.

Serious or Rare Side Effects

  • Severe liver injury: jaundice, elevated enzymes.
  • Bone fractures: increased risk of osteoporosis‑related breaks.
  • Pulmonary embolism: sudden shortness of breath, chest pain.
  • Severe allergic reactions: rash, swelling, anaphylaxis.
  • QT interval prolongation: cardiac rhythm disturbances.
  • Stevens‑Johnson syndrome: severe skin blistering.

Precautions & Warnings

Before initiating Letrozole therapy, several safety considerations should be observed.

  • Assess bone health: evaluate risk of osteoporosis and consider calcium/vitamin D supplementation.
  • Monitor liver function: perform baseline and periodic liver enzyme tests.
  • Check lipid profile: estrogen reduction may affect cholesterol levels.
  • Contraindicated in pregnancy: Letrozole is category X and must not be used by pregnant women.
  • Use caution in cardiovascular disease: monitor for thromboembolic events.
  • Store at ambient temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Letrozole can interact with other medicines, influencing its efficacy or safety.

Major Interactions (Avoid)

  • Strong CYP3A4 inducers (e.g., rifampin, carbamazepine): may reduce Letrozole levels.
  • Estrogen‑containing hormone therapy: antagonizes therapeutic effect.
  • Tamoxifen: combined use may diminish anti‑estrogen activity.
  • Warfarin: increased anticoagulant effect, risk of bleeding.

Moderate Interactions (Monitor Closely)

  • CYP2C19 inhibitors (e.g., fluoxetine): may modestly raise Letrozole concentrations.
  • Statins: potential for additive liver toxicity.
  • Antihypertensives: monitor blood pressure changes.
  • Glucocorticoids: may affect bone health when combined.

Frequently Asked Questions

Letrozol Synthon contains letrozole, an aromatase inhibitor indicated for the adjuvant treatment of hormone receptor‑positive breast cancer in postmenopausal women and as first‑line therapy for metastatic hormone‑sensitive breast cancer.

Letrozole blocks the aromatase enzyme, preventing the conversion of androgens to estrogen. This reduces circulating estrogen levels, limiting the growth stimulus for estrogen‑dependent breast cancer cells.

The prescribed dose of letrozole is determined by the treating physician based on the patient’s clinical condition, renal and hepatic function, and other individual factors. Patients should follow the exact dosing instructions provided by their healthcare professional.

Letrozole is classified as pregnancy category X, meaning it is contraindicated in pregnancy because it can cause fetal harm. It is also not recommended during breastfeeding, as it may pass into milk and affect the infant.

To order Letrozol Synthon, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Letrozole, as a non‑steroidal aromatase inhibitor, offers a different mechanism from selective estrogen receptor modulators such as tamoxifen. It generally provides superior estrogen suppression in postmenopausal patients, leading to improved disease‑free survival in many clinical trials.

Letrozol Synthon should be stored at ambient temperature, below 25 °C, in its original packaging to protect it from moisture and light. Do not store in a location with high humidity or direct sunlight.

Letrozol Synthon is taken orally, usually as a tablet, with or without food. The patient should swallow the tablet whole with water and follow the dosing schedule prescribed by the clinician.

Serious risks include severe liver injury, bone fractures due to decreased estrogen, pulmonary embolism, and rare but severe skin reactions such as Stevens‑Johnson syndrome. Patients should be monitored regularly for these events.

Letrozol Synthon should not be used by pregnant women, individuals with known hypersensitivity to letrozole or any component of the formulation, and patients with severe liver impairment without careful medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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