Product image of Letrozol Tarbis Farma (Letrozole) supplied by GNH India

Letrozol Tarbis Farma

Active Ingredient:
Letrozole
Origin:
EU

Letrozol Tarbis Farma (Letrozole)

Letrozole, the active ingredient in Letrozol Tarbis Farma, is an aromatase inhibitor presented as a tablet for oral use. It is indicated for the treatment of hormone receptor‑positive breast cancer in postmenopausal women, both as adjuvant therapy and for advanced disease.

GNH India supplies Letrozol Tarbis Farma as a licensed, GDP‑compliant international pharmaceutical supplier, providing the EU‑origin product to oncology centres, hospitals and pharmacies worldwide while ensuring quality and regulatory compliance.

Manufacturer / TM Owner

Tarbis Farma, S.L.

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Indications & Clinical Uses

  • Letrozole is used in the management of estrogen‑dependent breast cancer, acting on the aromatase pathway.
  • Hormone receptor‑positive breast cancer in postmenopausal women: reduces estrogen production to slow tumor growth.
  • Adjuvant treatment of early breast cancer: lowers risk of recurrence after surgery.
  • Metastatic breast cancer in postmenopausal patients: provides disease control when cancer has spread.

How It Works

  • Letrozole selectively and non‑steroidally inhibits the aromatase enzyme (CYP19A1) in peripheral tissues, blocking the conversion of androstenedione and testosterone into estrone and estradiol. By lowering circulating estrogen levels, it deprives estrogen‑dependent tumor cells of a growth stimulus, thereby inhibiting proliferation and inducing apoptosis in hormone‑sensitive breast cancer.

Side Effects

Letrozole may be associated with a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Hot flashes: transient episodes of increased skin temperature and sweating.
  • Joint and muscle pain: arthralgia and myalgia affecting mobility.
  • Fatigue: persistent tiredness not relieved by rest.
  • Nausea: mild to moderate upset stomach.
  • Bone density loss: decreased mineral content leading to osteoporosis risk.

Serious or Rare Side Effects

  • Severe cardiovascular events: including myocardial infarction or stroke.
  • Liver toxicity: elevated transaminases or hepatitis.
  • Severe allergic reactions: anaphylaxis or angioedema.

Precautions & Warnings

  • When prescribing Letrozole, clinicians should consider several precautionary measures to ensure patient safety.
  • Assess bone health: baseline DEXA scan recommended due to risk of osteoporosis.
  • Monitor liver function: periodic tests to detect hepatotoxicity.
  • Evaluate cardiovascular risk: consider history of thromboembolic disease.
  • Avoid use in pregnancy: drug is contraindicated in pregnant women.
  • Drug interactions: review concomitant medications that affect estrogen levels.
  • Store at ambient temperature: keep below 25 °C in original packaging, protect from moisture.

Avoid Interactions

Letrozole can interact with other medicines, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • Concurrent use of estrogen replacement therapy: negates aromatase inhibition.
  • Strong CYP3A4 inducers (e.g., rifampin, carbamazepine): may reduce plasma levels.
  • Tamoxifen: antagonistic effects on estrogen pathways.

Moderate Interactions (Monitor Closely)

  • Warfarin: potential increase in anticoagulant effect, monitor INR.
  • SSRIs/SNRIs (e.g., fluoxetine): may affect metabolism, observe for side effects.
  • Cholesterol‑lowering agents (e.g., statins): monitor liver enzymes.

Frequently Asked Questions

Letrozol Tarbis Farma contains letrozole, an aromatase inhibitor indicated for the treatment of hormone receptor‑positive breast cancer in postmenopausal women. It is used both as adjuvant therapy after surgery and for controlling disease that has spread to other parts of the body.

Letrozole works by selectively blocking the aromatase enzyme, which converts androgens into estrogens in peripheral tissues. By reducing estrogen levels, the drug deprives estrogen‑dependent breast cancer cells of a key growth signal, thereby inhibiting tumor proliferation and promoting cell death.

The dose of letrozole is determined by the prescribing physician based on the patient’s clinical condition, treatment setting and other individual factors. The prescriber will select the appropriate strength and dosing schedule; patients should follow the exact instructions provided on the prescription label.

Letrozole is classified as contraindicated during pregnancy because it can interfere with fetal development by lowering estrogen levels. Safety data for breastfeeding are insufficient, and the drug may pass into breast milk. Women who are pregnant, planning to become pregnant, or nursing should not use letrozole.

To order Letrozol Tarbis Farma, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Letrozole belongs to the aromatase inhibitor class, similar to anastrozole and exemestane. Compared with anastrozole, letrozole generally provides a slightly stronger suppression of estrogen levels, which may translate into marginally better disease control in some patients. Choice of agent depends on physician preference, patient tolerance and specific clinical factors.

Letrozol Tarbis Farma tablets should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed to maintain stability throughout its shelf life.

Letrozol Tarbis Farma is taken orally, usually as a whole tablet swallowed with water. It is typically taken once daily, at the same time each day, with or without food, unless the prescribing physician provides different instructions.

Serious risks associated with letrozole include cardiovascular events such as heart attack or stroke, severe liver toxicity manifested by elevated liver enzymes or hepatitis, and rare allergic reactions like anaphylaxis. Patients should promptly report chest pain, sudden weakness, jaundice, or signs of severe allergic response to their healthcare provider.

Letrozole should not be used by women who are pregnant or may become pregnant, as it can harm fetal development. It is also contraindicated in patients with known hypersensitivity to letrozole or any component of the formulation, and in those with severe liver impairment where the drug’s metabolism could be compromised.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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