Product image of Letrozol Tecnimede (Letrozole) supplied by GNH India

Letrozol Tecnimede

Active Ingredient:
Letrozole
Origin:
EU

Letrozol Tecnimede (Letrozole)

Letrozole, the active ingredient in Letrozol Tecnimede, is an aromatase inhibitor presented as a tablet for oral use. It is employed to treat hormone receptor‑positive breast cancer in postmenopausal women, both in early‑stage adjuvant settings and in metastatic disease. The medication works by reducing estrogen production, thereby limiting tumor growth.

GNH India supplies Letrozol Tecnimede as a licensed, GDP‑compliant international pharmaceutical supplier serving oncology centres, hospitals and pharmacies worldwide, ensuring quality and regulatory conformity for global distribution and reliable delivery services.

Manufacturer / TM Owner

Tecnimede - Sociedade Técnico-Medicinal, Sa

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Indications & Clinical Uses

  • Letrozole is used in the management of hormone‑dependent breast cancer, targeting estrogen‑driven tumor growth.
  • Early‑stage hormone receptor‑positive breast cancer: reduces risk of recurrence when given as adjuvant therapy.
  • Metastatic hormone receptor‑positive breast cancer: delays disease progression and improves survival.
  • Extended adjuvant therapy after tamoxifen: provides continued estrogen suppression to prevent late recurrence.

How It Works

  • Letrozole acts as a reversible inhibitor of the aromatase enzyme, which converts androgens to estrogens in peripheral tissues. By binding to the enzyme’s active site, it blocks estrogen synthesis, leading to markedly reduced circulating estradiol levels. The resulting hypo‑estrogenic state deprives estrogen‑dependent breast cancer cells of a growth stimulus, thereby inhibiting tumor proliferation. The inhibition is dose‑dependent and persists for several days after dosing, providing sustained estrogen suppression.

Side Effects

Letrozole may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Hot flashes: transient warmth and sweating.
  • Joint and muscle pain: arthralgia and myalgia.
  • Fatigue: persistent tiredness.
  • Nausea: mild to moderate upset stomach.

Serious or Rare Side Effects

  • Severe liver injury: jaundice or elevated enzymes.
  • Bone fracture or osteoporosis: increased risk of skeletal fragility.
  • Pulmonary embolism or deep vein thrombosis: signs of clot formation in lungs or veins.

Precautions & Warnings

  • Before initiating Letrozole therapy, several safety considerations should be reviewed.
  • Pregnancy: contraindicated (Category X); avoid use in pregnant women.
  • Bone health: assess baseline bone mineral density and consider calcium/vitamin D supplementation.
  • Cardiovascular risk: evaluate history of thromboembolic events before treatment.
  • Liver function: perform hepatic function tests and monitor periodically.
  • Drug interactions: review concomitant medications for potential CYP2C19 inhibitors or estrogen‑containing agents.
  • Store at ambient temperature below 25°C: keep in original packaging, protect from moisture and light.

Avoid Interactions

Letrozole can interact with other medicines, affecting its efficacy or safety.

Major Interactions (Avoid)

  • Strong CYP2C19 inhibitors (e.g., fluconazole, voriconazole): may increase letrozole plasma concentrations.
  • Estrogen‑containing products (hormone replacement therapy, oral contraceptives): antagonize therapeutic effect.

Moderate Interactions (Monitor Closely)

  • Anticoagulants (warfarin): may require INR monitoring due to altered metabolism.
  • Tamoxifen: concurrent use can reduce effectiveness of both agents.
  • Selective serotonin reuptake inhibitors (e.g., fluoxetine): may modestly affect letrozole clearance.

Frequently Asked Questions

Letrozol Tecnimede contains letrozole, an aromatase inhibitor indicated for the treatment of hormone receptor‑positive breast cancer in postmenopausal women. It is used in both early‑stage adjuvant therapy to reduce recurrence risk and in metastatic disease to slow tumor progression.

Letrozole works by reversibly binding to the aromatase enzyme, which converts androgens into estrogens in peripheral tissues. Inhibiting this enzyme sharply lowers circulating estrogen levels, depriving estrogen‑dependent breast cancer cells of a key growth signal and thereby inhibiting tumor growth.

The specific dose of Letrozol Tecnimede is determined by the prescribing physician based on the patient’s clinical condition, treatment setting and individual factors. The prescriber will select the appropriate strength and dosing schedule in accordance with approved guidelines.

Letrozol Tecnimede is classified as pregnancy category X, meaning it is contraindicated in pregnant women because it can cause fetal harm. It is also not recommended for breastfeeding mothers, as it may be excreted in milk and affect the infant.

To order Letrozol Tecnimede, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

The main alternative within the same class is anastrozole, another aromatase inhibitor. Both drugs lower estrogen levels, but letrozole is generally considered slightly more potent, offering marginally greater estrogen suppression. Choice between them depends on physician preference, patient tolerance and specific clinical considerations.

Letrozol Tecnimede should be stored at ambient temperature below 25 °C. Keep the tablets in the original container, protect them from moisture, heat and direct light. Do not store in the bathroom or near a kitchen sink to maintain product stability.

Letrozol Tecnimede is administered orally as a tablet. Patients should swallow the tablet whole with a glass of water, preferably at the same time each day. Food does not significantly affect absorption, so it can be taken with or without meals.

Serious risks include severe liver injury, osteoporosis leading to bone fractures, and thromboembolic events such as deep‑vein thrombosis or pulmonary embolism. Patients should report symptoms like persistent jaundice, severe bone pain, swelling of the limbs or sudden shortness of breath to their healthcare provider promptly.

Letrozol Tecnimede should not be used by pregnant or breastfeeding women, patients with known hypersensitivity to letrozole or other aromatase inhibitors, and individuals with severe liver impairment. Caution is also advised for patients with a history of osteoporosis or thromboembolic disease.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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