Product image of Letrozol Teva (Letrozole) supplied by GNH India

Letrozol Teva

Active Ingredient:
Letrozole
Origin:
EU

Letrozol Teva (Letrozole)

Letrozole, the active ingredient in Letrozol Teva, is an aromatase inhibitor presented as a tablet for oral use. It treats hormone receptor‑positive breast cancer in postmenopausal women.

GNH India supplies Letrozol Teva as a licensed, GDP‑compliant international pharmaceutical supplier serving oncology centres worldwide.

Manufacturer / TM Owner

Teva Nederland B.V.

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Indications & Clinical Uses

Letrozole is used in the management of estrogen‑dependent breast cancer, targeting hormone‑receptor‑positive disease.

  • Hormone receptor‑positive breast cancer in postmenopausal women: reduces estrogen production to inhibit tumor growth.
  • Advanced hormone receptor‑positive breast cancer: slows disease progression in metastatic settings.
  • Early‑stage hormone receptor‑positive breast cancer (adjuvant setting): lowers risk of recurrence after surgery.

How It Works

  • Letrozole selectively and reversibly inhibits the aromatase enzyme, which converts adrenal and ovarian androgens into estrogens. By blocking this peripheral conversion, circulating estrogen levels decline markedly, depriving estrogen‑dependent tumor cells of a growth stimulus. The reduction in estrogen also diminishes feedback inhibition of gonadotropins, but the primary anticancer effect derives from the lowered estrogen milieu that limits proliferation of hormone‑sensitive breast cancer cells.

Side Effects

Letrozole may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Hot flashes
  • Joint and muscle pain
  • Fatigue
  • Nausea or mild gastrointestinal upset

Serious or Rare Side Effects

  • Severe liver injury
  • Osteoporotic fractures
  • Pulmonary embolism or deep‑vein thrombosis
  • Severe allergic reactions such as Stevens‑Johnson syndrome

Precautions & Warnings

When prescribing Letrozole, clinicians should consider several safety measures.

  • Monitor bone health: assess risk of osteoporosis and consider calcium/vitamin D supplementation.
  • Assess liver function: perform baseline and periodic liver enzyme tests.
  • Evaluate cardiovascular risk: monitor lipid profile and blood pressure.
  • Avoid use in premenopausal women: drug is indicated for postmenopausal patients only.
  • Store at room temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Letrozole interacts with several medicines that may alter its efficacy or safety.

Major Interactions (Avoid)

  • Concurrent estrogen‑containing hormone therapy: negates therapeutic effect.
  • Strong CYP3A4 inducers (e.g., rifampin, carbamazepine): markedly reduce plasma levels.
  • Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may increase exposure and toxicity.

Moderate Interactions (Monitor Closely)

  • Warfarin: potential increase in anticoagulant effect; monitor INR.
  • Tamoxifen: possible antagonistic effect on estrogen modulation.
  • Selective serotonin reuptake inhibitors: may exacerbate hot flashes.

Frequently Asked Questions

Letrozol Teva contains letrozole, an aromatase inhibitor indicated for the treatment of hormone receptor‑positive breast cancer in postmenopausal women. It is used in advanced disease, as well as in the adjuvant setting to reduce the risk of cancer recurrence after surgery.

Letrozole blocks the aromatase enzyme, preventing the conversion of androgens to estrogens in peripheral tissues. This leads to a marked reduction in circulating estrogen, depriving estrogen‑dependent breast cancer cells of the hormone they need to grow and proliferate.

The dose of Letrozol Teva is determined by the prescribing physician based on clinical guidelines, patient characteristics, and treatment goals. Healthcare professionals select the appropriate strength and dosing schedule for each individual patient.

Letrozole is contraindicated during pregnancy because it can harm the developing fetus. It is also not recommended while breastfeeding, as it may pass into breast milk and affect the infant. Women of child‑bearing potential should use effective contraception during treatment.

To request Letrozol Teva, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

The primary alternative within the same class is anastrozole, another oral aromatase inhibitor. Both drugs lower estrogen levels, but pharmacokinetic profiles differ slightly; letrozole generally provides a more sustained suppression of estrogen, while anastrozole may have a shorter half‑life. Choice between them depends on physician preference, patient tolerance, and specific clinical scenarios.

Letrozol Teva tablets should be stored at room temperature, below 25 °C, in the original blister pack or container. Protect them from excess moisture, heat, and direct sunlight to maintain potency throughout the shelf life.

Letrozol Teva is taken orally, usually once daily, with a glass of water. It can be taken with or without food, but patients should follow the specific instructions provided by their healthcare provider.

Serious risks include severe liver injury, osteoporotic fractures, and thromboembolic events such as deep‑vein thrombosis or pulmonary embolism. Patients should promptly report signs of jaundice, unexplained bone pain, or sudden swelling and shortness of breath to their physician.

Letrozol Teva should not be used in premenopausal women, pregnant or nursing individuals, and patients with known hypersensitivity to letrozole or any component of the formulation. Caution is also advised for those with severe liver impairment or uncontrolled cardiovascular disease.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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