Product image of Letrozol Teva (Letrozole) supplied by GNH India

Letrozol Teva

Active Ingredient:
Letrozole
Origin:
EU

Letrozol Teva (Letrozole)

Letrozole, the active ingredient in Letrozol Teva, is a aromatase inhibitor presented as a oral tablet for oral use. It treats hormone receptor‑positive breast cancer in postmenopausal women.

GNH India supplies Letrozol Teva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Teva Sweden Ab

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Indications & Clinical Uses

Letrozol Teva is an aromatase inhibitor used in the management of hormone‑dependent breast cancer.

  • Adjuvant treatment of early‑stage hormone receptor‑positive breast cancer in postmenopausal women: reduces risk of recurrence.
  • Metastatic hormone receptor‑positive breast cancer in postmenopausal women: slows disease progression.
  • Neoadjuvant therapy before surgery in postmenopausal women with hormone receptor‑positive breast cancer: may shrink tumor size.

How It Works

  • Letrozole reversibly binds to the aromatase enzyme in a non‑competitive manner, blocking the conversion of androgens to estrogens. By lowering systemic estrogen levels, it deprives estrogen‑dependent tumor cells of a growth stimulus, thereby inhibiting proliferation of hormone‑sensitive breast cancer cells.

Side Effects

Letrozol Teva may cause a range of adverse reactions.

Common Side Effects

  • Hot flashes: sudden feeling of warmth and sweating.
  • Joint and muscle pain: aching in limbs or back.
  • Fatigue: persistent tiredness.
  • Nausea: mild to moderate upset stomach.
  • Headache: pressure or throbbing pain.
  • Dizziness: light‑headed sensation.

Serious or Rare Side Effects

  • Severe liver injury: jaundice, elevated enzymes.
  • Bone fracture: increased risk of osteoporosis.
  • Pulmonary embolism: sudden shortness of breath.
  • Allergic reaction: rash, swelling, anaphylaxis.
  • Elevated cholesterol: dyslipidaemia.
  • Cardiac arrhythmia: QT interval prolongation.

Precautions & Warnings

Before initiating Letrozol Teva, clinicians should consider several safety measures.

  • Assess bone health: monitor for osteoporosis and consider calcium/vitamin D supplementation.
  • Monitor liver function: periodic liver enzyme tests are recommended.
  • Check lipid profile: watch for increases in cholesterol levels.
  • Contraindicated in pregnancy: teratogenic risk requires strict avoidance.
  • Use caution in patients with cardiovascular disease: evaluate risk of thromboembolic events.
  • Store at below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Letrozol Teva can interact with other medicines, requiring attention to avoid reduced efficacy or increased toxicity.

Major Interactions (Avoid)

  • Estrogen replacement therapy: antagonises letrozole's effect.
  • Strong CYP3A4 inducers (e.g., rifampin, carbamazepine): may markedly lower plasma concentrations.
  • Tamoxifen: opposing mechanisms may diminish therapeutic benefit.

Moderate Interactions (Monitor Closely)

  • Warfarin: letrozole may increase INR, requiring closer coagulation monitoring.
  • CYP2C19 inhibitors (e.g., fluconazole): can raise letrozole exposure.
  • SSRIs that affect CYP2D6: may alter metabolism and affect efficacy.

Frequently Asked Questions

Letrozol Teva contains letrozole, an aromatase inhibitor indicated for the treatment of hormone receptor‑positive breast cancer in postmenopausal women, including adjuvant, neoadjuvant and metastatic settings.

Letrozole blocks the aromatase enzyme, preventing the conversion of androgens into estrogen. The resulting drop in estrogen levels deprives estrogen‑dependent tumor cells of a growth signal, slowing or stopping cancer progression.

The prescribed dose of Letrozol Teva is determined by the treating physician based on the patient’s clinical condition, renal and hepatic function, and other individual factors. Patients should follow the prescriber’s instructions exactly.

Letrozol Teva is classified as Pregnancy Category X, meaning it is contraindicated in pregnancy due to known teratogenic risk. It is also not recommended while breastfeeding because it may pass into milk and affect the infant.

To order Letrozol Teva, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Letrozol Teva (letrozole) is a third‑generation aromatase inhibitor with a long half‑life and potent estrogen suppression. Compared with anastrozole or exemestane, letrozole often provides slightly greater estrogen reduction, which may translate into marginally higher efficacy in certain clinical scenarios, though safety profiles are broadly similar.

Letrozol Teva tablets should be stored at temperatures below 25 °C, in their original packaging, and protected from moisture and direct sunlight. Keep out of reach of children and do not use if the packaging is damaged.

Letrozol Teva is taken orally, usually once daily, with or without food, as directed by the prescribing clinician. Swallow the tablet whole with a glass of water; do not crush or chew unless instructed otherwise.

Serious risks include severe liver injury, osteoporosis‑related fractures, pulmonary embolism, allergic reactions such as anaphylaxis, and cardiac arrhythmias like QT prolongation. Patients should be monitored regularly for these events, and any concerning symptoms reported promptly.

Letrozol Teva should not be used by pregnant women, individuals with known hypersensitivity to letrozole or any tablet components, and patients with severe liver impairment. Caution is also advised for those with uncontrolled cardiovascular disease or a history of thromboembolic events.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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