Product image of Letrozol Viatris (Letrozole) supplied by GNH India

Letrozol Viatris

Active Ingredient:
Letrozole
Origin:
EU

Letrozol Viatris (Letrozole)

Letrozole, the active ingredient in Letrozol Viatris, is an aromatase inhibitor presented as an oral tablet for oral use. It reduces estrogen production and is used in the management of estrogen‑positive breast cancer in postmenopausal women, as approved in the European Union.

GNH India supplies Letrozol Viatris as a licensed, GDP‑compliant international pharmaceutical supplier serving oncology centres, hospitals and pharmacies worldwide, ensuring quality and regulatory conformity for global distribution. The product conforms to EU pharmaceutical standards and is marketed across European Union member states.

Manufacturer / TM Owner

Viatris Limited

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Indications & Clinical Uses

Letrozole acts on the estrogen synthesis pathway and is employed in hormone‑dependent breast cancer therapy.

  • Adjuvant treatment of estrogen‑receptor‑positive early breast cancer: lowers risk of recurrence after surgery.
  • Metastatic breast cancer in postmenopausal women: helps control disease progression.
  • Neoadjuvant therapy before surgery: may reduce tumor size to facilitate operative management.

How It Works

  • Letrozole reversibly binds to the aromatase enzyme, inhibiting the conversion of androgens to estrogens. By blocking this final step in estrogen biosynthesis, systemic estrogen levels decline, depriving estrogen‑dependent tumor cells of growth stimulation and thereby slowing cancer progression.

Side Effects

Letrozole may cause a range of adverse reactions.

Common Side Effects

  • Hot flashes: sudden feeling of warmth, often with sweating.
  • Joint and muscle pain: discomfort in limbs and back.
  • Fatigue: persistent tiredness not relieved by rest.
  • Nausea: mild to moderate upset stomach.
  • Headache: pressure or throbbing pain in the head.
  • Increased sweating: excessive perspiration.

Serious or Rare Side Effects

  • Severe liver injury: jaundice, dark urine, abdominal pain.
  • Bone fractures: due to decreased bone mineral density.
  • Pulmonary embolism: sudden shortness of breath, chest pain.
  • Allergic reactions: rash, itching, swelling, or anaphylaxis.
  • Elevated cholesterol: significant rise in blood lipid levels.

Precautions & Warnings

Before initiating Letrozole therapy, several safety considerations are recommended.

  • Monitor bone health: assess risk of osteoporosis and consider calcium/vitamin D supplementation.
  • Check liver function: perform baseline and periodic liver enzyme tests.
  • Evaluate lipid profile: monitor cholesterol levels during treatment.
  • Avoid use in premenopausal women: the drug is not indicated for this population.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Letrozole can interact with other medicines, requiring careful management.

Major Interactions (Avoid)

  • Concurrent tamoxifen: antagonistic effect reduces therapeutic benefit.
  • Strong CYP3A4 inducers (e.g., rifampin, carbamazepine): may markedly lower letrozole plasma concentrations.
  • Estrogen replacement therapy: diminishes the drug’s anti‑estrogenic action.

Moderate Interactions (Monitor Closely)

  • Warfarin: letrozole may increase INR, necessitating closer coagulation monitoring.
  • CYP2C19 inhibitors (e.g., fluconazole): can raise letrozole levels, watch for toxicity.
  • Statins metabolized by CYP3A4: monitor for muscle-related side effects.

Frequently Asked Questions

Letrozol Viatris contains letrozole, an aromatase inhibitor indicated for the treatment of estrogen‑receptor‑positive breast cancer in postmenopausal women. It is used in adjuvant, neoadjuvant, and metastatic settings to reduce estrogen‑driven tumor growth.

Letrozole blocks the aromatase enzyme, which converts androgens into estrogens. By inhibiting this conversion, systemic estrogen levels fall, depriving hormone‑sensitive breast cancer cells of the estrogen needed for proliferation.

The prescribed dose of Letrozol Viatris is determined by the treating physician based on the patient’s clinical condition, renal and hepatic function, and other individual factors. The prescriber sets the exact regimen.

Letrozole is contraindicated in pregnancy because it can harm the developing fetus. It is also not recommended during breastfeeding, as it may pass into breast milk and affect the infant. Women of child‑bearing potential should use effective contraception.

To order Letrozol Viatris, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Letrozole is a third‑generation aromatase inhibitor with a high potency and a longer half‑life compared with earlier agents such as anastrozole. Clinical studies have shown comparable efficacy, while some data suggest a modest advantage in disease‑free survival for certain patient groups.

Letrozol Viatris tablets should be stored at room temperature, below 25 °C, in the original packaging to protect from moisture and light. Keep the container tightly closed and out of reach of children.

Letrozol Viatris is taken orally, usually once daily, with or without food. Patients should swallow the tablet whole with a glass of water and follow the dosing schedule prescribed by their healthcare professional.

Serious risks include severe liver injury, significant bone loss leading to fractures, and rare events such as pulmonary embolism or severe allergic reactions. Patients should be monitored regularly for liver function, bone health, and any signs of thromboembolic disease.

Letrozol Viatris should not be used in premenopausal women, pregnant or nursing individuals, and patients with known hypersensitivity to letrozole or any excipients. Caution is also advised for those with severe hepatic impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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