Product image of Letrozol Winthrop (Letrozole) supplied by GNH India

Letrozol Winthrop

Active Ingredient:
Letrozole
Origin:
EU

Letrozol Winthrop (Letrozole)

Letrozole, the active ingredient in Letrozol Winthrop, is an aromatase inhibitor presented as an oral formulation for oral use. It is employed to treat postmenopausal women with hormone receptor‑positive breast cancer by lowering estrogen levels that can stimulate tumor growth.

GNH India supplies Letrozol Winthrop as a licensed, GDP‑compliant international pharmaceutical supplier serving oncology centres worldwide. The company adheres to stringent quality standards and provides reliable sourcing for hospitals, pharmacies and clinical research sites. All batches are manufactured under EU GMP guidelines and undergo full batch release testing.

Manufacturer / TM Owner

Winthrop Arzneimittel Gmbh

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Indications & Clinical Uses

  • Letrozole is used in the management of hormone‑dependent breast cancer, targeting estrogen‑driven disease pathways.
  • Postmenopausal hormone receptor‑positive breast cancer: reduces estrogen production to slow tumor progression.
  • Adjuvant therapy for early‑stage hormone receptor‑positive breast cancer: lowers risk of recurrence after surgery.
  • Metastatic breast cancer in postmenopausal women: helps control disease spread and prolong survival.

How It Works

  • Letrozole reversibly inhibits the aromatase enzyme, which catalyzes the conversion of androgens to estrogen in peripheral tissues. This inhibition leads to a marked reduction in circulating estrogen levels, thereby decreasing estrogen‑driven stimulation of hormone‑sensitive breast cancer cells and slowing tumor growth.

Side Effects

Letrozol Winthrop may cause a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Hot flashes
  • Joint and muscle pain
  • Fatigue
  • Nausea
  • Headache

Serious or Rare Side Effects

  • Severe bone loss or osteoporosis leading to fractures
  • Liver function abnormalities
  • Deep‑vein thrombosis or pulmonary embolism
  • Severe allergic reactions (anaphylaxis)

Precautions & Warnings

  • When prescribing Letrozol Winthrop, clinicians should observe several precautionary measures to ensure patient safety.
  • Monitor bone density: assess risk of osteoporosis and consider calcium/vitamin D supplementation.
  • Check liver function: perform periodic hepatic enzyme tests.
  • Evaluate lipid profile: hypercholesterolemia may develop and require management.
  • Assess cardiovascular risk: review history of heart disease before initiating therapy.
  • Avoid use in premenopausal women: drug is ineffective and may cause adverse hormonal effects.
  • Store at ambient temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Letrozol Winthrop can interact with other medicines, influencing its efficacy or safety.

Major Interactions (Avoid)

  • Tamoxifen: antagonistic effect reduces therapeutic benefit.
  • Strong CYP3A4 inducers (e.g., rifampin, carbamazepine): markedly lower letrozole plasma levels.
  • Strong CYP2A6 inhibitors (e.g., fluvoxamine): increase exposure and risk of toxicity.

Moderate Interactions (Monitor Closely)

  • Hormone replacement therapy: added estrogen may counteract letrozole action.
  • Statins: potential additive impact on liver function; monitor enzymes.
  • Warfarin: letrozole may affect INR; check coagulation parameters regularly.

Frequently Asked Questions

Letrozol Winthrop is indicated for the treatment of postmenopausal women with hormone receptor‑positive breast cancer, including both early‑stage (adjuvant) and metastatic disease, where lowering estrogen helps control tumor growth.

Letrozole reversibly blocks the aromatase enzyme, preventing the conversion of androgens to estrogen in peripheral tissues. This reduction in systemic estrogen deprives estrogen‑dependent cancer cells of a key growth stimulus.

The prescribed dose is determined by the treating physician based on the patient’s clinical condition, regulatory guidelines, and individual response. Patients should follow the exact dosing instructions provided on the prescription label.

Letrozole is contraindicated in pregnancy and its safety during breastfeeding has not been established. Women of child‑bearing potential should use effective contraception during treatment and for a period after discontinuation as advised by their healthcare provider.

Submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Letrozole is a third‑generation aromatase inhibitor with a longer half‑life and higher potency than earlier agents such as anastrozole. It is often preferred for its once‑daily dosing and demonstrated efficacy in both adjuvant and metastatic breast cancer, though individual choice depends on patient tolerance and clinical judgment.

Store at ambient temperature, below 25 °C, in the original packaging. Protect the product from moisture, excessive heat and direct sunlight. Keep out of reach of children and do not use after the expiry date.

The medication is taken orally, usually once daily, with or without food, as directed by the prescribing clinician. Swallow the tablet whole with a glass of water and do not crush or split it unless instructed.

Serious adverse events include severe osteoporosis leading to fractures, hepatic dysfunction, thromboembolic events such as deep‑vein thrombosis or pulmonary embolism, and rare but life‑threatening allergic reactions. Patients should be monitored regularly for these conditions.

The drug is not indicated for premenopausal women, pregnant or nursing individuals, and should be avoided in patients with known hypersensitivity to letrozole or any excipients. Caution is also advised in those with severe liver disease or uncontrolled cardiovascular disorders.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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