Product image of Letrozole Accord (Letrozole) supplied by GNH India

Letrozole Accord

Active Ingredient:
Letrozole
Origin:
EU

Letrozole Accord (Letrozole)

Letrozole, the active ingredient in Letrozole Accord, is an aromatase inhibitor presented as a tablet for oral use. It is employed to treat hormone receptor‑positive breast cancer in postmenopausal women. GNH India supplies Letrozole Accord as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Accord Healthcare B.V.

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

  • Letrozole is an aromatase inhibitor used in the management of hormone‑dependent breast cancer.
  • Hormone receptor‑positive breast cancer (postmenopausal): reduces estrogen production to limit tumor growth.
  • Advanced or metastatic breast cancer (postmenopausal): helps control disease progression.
  • Adjuvant therapy after surgery (postmenopausal): decreases risk of cancer recurrence.

How It Works

  • Letrozole reversibly binds to the aromatase enzyme, inhibiting its activity and thereby decreasing the peripheral conversion of androgens to estrogens. This reduction in circulating estrogen limits the stimulation of estrogen‑dependent tumor cells, contributing to disease control in hormone‑sensitive breast cancer.

Side Effects

Adverse reactions may occur with Letrozole therapy.

Common Side Effects

  • Hot flashes: sudden feeling of warmth and sweating.
  • Joint and muscle pain: aching in joints or muscles.
  • Fatigue: persistent tiredness.
  • Nausea: mild stomach upset.
  • Headache: mild to moderate head pain.

Serious or Rare Side Effects

  • Severe liver injury: jaundice, elevated liver enzymes.
  • Bone fracture: increased risk due to reduced bone density.
  • Pulmonary embolism: sudden shortness of breath or chest pain.
  • Allergic reactions: rash, swelling, or anaphylaxis.
  • Severe hypertension: markedly high blood pressure.

Precautions & Warnings

  • Before initiating Letrozole, several safety considerations are recommended.
  • Pregnancy: contraindicated (Category X); avoid use in pregnant women.
  • Bone health: monitor bone mineral density regularly.
  • Cardiovascular risk: assess and manage underlying heart disease.
  • Liver function: evaluate hepatic status prior to treatment.
  • Drug interactions: review concomitant medications for potential effects.
  • Store at room temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Letrozole may interact with other medicines, requiring attention to avoid reduced efficacy or increased toxicity.

Major Interactions (Avoid)

  • Strong CYP3A4 inducers (e.g., rifampin): may lower letrozole levels.
  • Tamoxifen: antagonistic effect on estrogen suppression.
  • Estrogen replacement therapy: counteracts letrozole action.

Moderate Interactions (Monitor Closely)

  • Warfarin: may increase INR and bleeding risk.
  • CYP2C19 inhibitors (e.g., fluconazole): may raise letrozole plasma concentrations.
  • Statins: monitor for potential muscle toxicity.

Frequently Asked Questions

Letrozole Accord contains letrozole, an aromatase inhibitor indicated for the treatment of hormone receptor‑positive breast cancer in postmenopausal women, including adjuvant, advanced, and metastatic disease settings.

Letrozole blocks the aromatase enzyme, which converts androgens into estrogens. By inhibiting this conversion, it lowers circulating estrogen levels, reducing the hormonal stimulation of estrogen‑dependent breast cancer cells.

The specific dose and regimen of Letrozole Accord are determined by the prescribing clinician based on the patient’s condition, treatment goals, and clinical guidelines. Patients should follow the prescriber’s instructions.

Letrozole is classified as Pregnancy Category X, meaning it is contraindicated in pregnancy due to potential fetal harm. It is also not recommended for breastfeeding women because it may pass into breast milk.

To order, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Letrozole, as an aromatase inhibitor, differs from selective estrogen receptor modulators like tamoxifen by directly lowering estrogen production rather than blocking the receptor. This mechanism often provides greater estrogen suppression in postmenopausal patients, making it a preferred option in many treatment protocols.

Letrozole Accord should be stored at room temperature, below 25 °C, in its original packaging. Protect the tablets from moisture, light, and excessive heat to maintain stability.

Letrozole Accord is taken orally, typically as a whole tablet with water. It is usually taken once daily, but the exact timing and any food considerations should follow the prescribing physician’s guidance.

Serious risks include severe liver injury, bone fractures due to decreased bone density, pulmonary embolism, and significant hypertension. Patients should be monitored regularly for these conditions, and any sudden symptoms should be reported to a healthcare professional immediately.

Letrozole should not be used by pregnant or breastfeeding women, individuals with known hypersensitivity to letrozole or any component of the formulation, and patients with severe liver impairment without careful medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Related Products

Other formulations containing Letrozole

A

A
A

A
A

A
A

A

Browse all products →

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Regulatory recognitions

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.

SGS GSDP Certification

GSDP Compliant from SGS

URS ISO 9001

URS ISO 9001 Certification

FDA Maharashtra

Licensed by FDA Maharashtra

IEC License DGFT

IEC License issued by DGFT