Product image of Letrozole Accord Healthcare Ireland (Letrozole) supplied by GNH India

Letrozole Accord Healthcare Ireland

Active Ingredient:
Letrozole
Origin:
EU

Letrozole Accord Healthcare Ireland (Letrozole)

Letrozole, the active ingredient in Letrozole Accord Healthcare Ireland, is an aromatase inhibitor presented as an oral tablet for oral use. It is used to treat hormone receptor‑positive breast cancer in postmenopausal women. GNH India supplies Letrozole Accord Healthcare Ireland as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Accord Healthcare Ireland Limited

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Indications & Clinical Uses

Letrozole acts on estrogen‑dependent breast cancer pathways, reducing estrogen levels to inhibit tumor growth.

  • Hormone receptor‑positive breast cancer in postmenopausal women: decreases estrogen production to slow tumor progression.
  • Adjuvant treatment of early‑stage hormone receptor‑positive breast cancer: helps prevent disease recurrence after surgery.
  • Metastatic hormone receptor‑positive breast cancer: reduces disease progression and improves survival outcomes.

How It Works

  • Letrozole reversibly binds to the aromatase enzyme, blocking the conversion of androgens to estrogens. By inhibiting aromatase activity, systemic estrogen levels decline, limiting the growth stimulus for estrogen‑dependent tumor cells in postmenopausal patients.

Side Effects

Letrozole may cause a range of adverse reactions, from mild to serious.

Common Side Effects

  • Hot flashes: sudden feeling of warmth and sweating.
  • Joint and muscle pain: aching in joints or muscles.
  • Nausea: mild to moderate upset stomach.
  • Fatigue: persistent tiredness.
  • Headache: mild to moderate pain.
  • Dizziness: sensation of light‑headedness.

Serious or Rare Side Effects

  • Severe liver injury: jaundice, elevated liver enzymes.
  • Bone fractures: increased risk due to lowered estrogen.
  • Deep vein thrombosis or pulmonary embolism: clot formation in veins.
  • Severe allergic reactions: rash, swelling, difficulty breathing.
  • QT interval prolongation: potential heart rhythm disturbances.
  • Hypercholesterolemia: significant rise in cholesterol levels.

Precautions & Warnings

When prescribing Letrozole, clinicians should consider several safety measures.

  • Bone health monitoring: assess bone mineral density regularly.
  • Liver function testing: evaluate hepatic enzymes before and during therapy.
  • Cardiovascular risk assessment: monitor for signs of thrombosis.
  • Drug interaction review: check concomitant medications for potential interactions.
  • Patient counseling: inform about hot flashes and fatigue.
  • Store at ambient temperature: keep in original packaging, protect from moisture.

Avoid Interactions

Letrozole can interact with other medicines, affecting its efficacy or safety.

Major Interactions (Avoid)

  • Strong CYP3A4 inducers (e.g., rifampin): may reduce Letrozole effectiveness.
  • Estrogen‑containing hormonal therapies: can counteract aromatase inhibition.
  • Tamoxifen: antagonistic action may diminish therapeutic benefit.

Moderate Interactions (Monitor Closely)

  • Warfarin: Letrozole may increase INR and bleeding risk.
  • Statins: possible heightened risk of myopathy.
  • SSRIs (e.g., fluoxetine): may alter Letrozole metabolism.
  • Anticonvulsants (e.g., carbamazepine): may affect plasma levels.
  • Antifungal agents (e.g., ketoconazole): could increase Letrozole exposure.

Frequently Asked Questions

Letrozole is prescribed for hormone receptor‑positive breast cancer in postmenopausal women. It is used as an adjuvant therapy after surgery, as well as for metastatic disease, to lower estrogen levels and slow tumor growth.

Letrozole works by reversibly inhibiting the aromatase enzyme, which converts androgens into estrogen. By blocking this conversion, systemic estrogen concentrations drop, depriving estrogen‑dependent cancer cells of a growth stimulus.

The specific dose and dosing schedule of Letrozole are determined by the prescribing clinician based on the patient’s condition, treatment goals, and clinical guidelines. Patients should follow the prescriber’s instructions exactly.

Letrozole is contraindicated in pregnancy because it can affect fetal development. It is also not recommended during breastfeeding, as it may pass into breast milk. Women of child‑bearing potential should use effective contraception while on therapy.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and necessary import documentation.

Letrozole belongs to the aromatase inhibitor class, which directly lowers estrogen production, unlike selective estrogen receptor modulators such as tamoxifen that block estrogen receptors. Aromatase inhibitors generally provide superior disease‑free survival in postmenopausal patients, but individual choice depends on patient factors and tolerability.

Letrozole tablets should be stored at ambient temperature, below 25 °C, in the original container to protect from moisture and light. Keep out of reach of children and do not use if the packaging is damaged.

Letrozole is taken orally, usually as a single tablet once daily, with or without food. Patients should swallow the tablet whole with water and follow any specific instructions from their healthcare provider.

Serious risks include severe liver injury, bone fractures due to decreased estrogen, and rare thromboembolic events such as deep vein thrombosis or pulmonary embolism. Patients should be monitored regularly for signs of these conditions.

Letrozole should not be used by premenopausal women, pregnant or breastfeeding individuals, and patients with known hypersensitivity to letrozole or any component of the formulation. Caution is also advised for patients with severe liver disease or uncontrolled cardiovascular conditions.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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