Product image of Letrozole Alter (Letrozole) supplied by GNH India

Letrozole Alter

Active Ingredient:
Letrozole
Origin:
EU

Letrozole Alter (Letrozole)

Letrozole, the active ingredient in Letrozole Alter, is an aromatase inhibitor presented as an oral tablet for oral use. It works by selectively inhibiting the aromatase enzyme, thereby reducing estrogen production, and is indicated for the treatment of hormone receptor‑positive breast cancer in postmenopausal women. The medication is administered under medical supervision and forms part of standard endocrine therapy protocols for this patient population.

GNH India supplies Letrozole Alter as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres and pharmacies worldwide.

Manufacturer / TM Owner

Laboratoires Alter

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Indications & Clinical Uses

Letrozole is used in the endocrine therapy pathway for hormone‑dependent breast cancer.

  • Hormone receptor‑positive breast cancer (early stage): reduces risk of recurrence by lowering estrogen levels.
  • Hormone receptor‑positive breast cancer (adjuvant setting): improves disease‑free survival when added to standard postoperative treatment.
  • Hormone receptor‑positive metastatic breast cancer: delays disease progression in postmenopausal patients.

How It Works

  • Letrozole is a selective, non‑steroidal inhibitor of the aromatase enzyme (CYP19A1). By binding to the enzyme’s active site, it blocks the conversion of androgens to estrogens in peripheral tissues. This results in a marked reduction of circulating estrogen, depriving estrogen‑dependent tumor cells of a growth stimulus. The inhibition is reversible and dose‑dependent, providing sustained estrogen suppression during therapy.

Side Effects

Letrozole may cause a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Hot flashes: transient feeling of warmth and sweating.
  • Joint and muscle pain: arthralgia or myalgia affecting daily activities.
  • Fatigue: persistent tiredness not relieved by rest.
  • Nausea: mild to moderate upset stomach.

Serious or Rare Side Effects

  • Severe liver injury: elevated transaminases or hepatitis.
  • Bone fracture: increased risk due to reduced bone mineral density.
  • Pulmonary embolism: sudden shortness of breath and chest pain.
  • Anaphylactic reaction: severe allergic response requiring emergency care.

Precautions & Warnings

When prescribing Letrozole, clinicians should observe several safety considerations.

  • Pregnancy contraindication: avoid use in pregnant women; teratogenic (Category X).
  • Bone health monitoring: assess bone mineral density periodically.
  • Liver function: evaluate hepatic enzymes before initiation and during treatment.
  • Cardiovascular risk: monitor for signs of thrombosis or hypertension.
  • Store at ambient temperature: keep below 25 °C in original packaging, protect from moisture.

Avoid Interactions

Letrozole can interact with other medicines, affecting its efficacy or safety.

Major Interactions (Avoid)

  • Estrogen replacement therapy: may counteract aromatase inhibition and reduce therapeutic benefit.
  • Strong CYP3A4 inducers (e.g., rifampin, carbamazepine): markedly decrease letrozole plasma levels.

Moderate Interactions (Monitor Closely)

  • Warfarin: may increase anticoagulant effect; monitor INR.
  • Statins (e.g., simvastatin): potential for increased muscle toxicity.
  • Antidepressants (e.g., fluoxetine): may alter letrozole metabolism; observe for side‑effect changes.

Frequently Asked Questions

Letrozole Alter contains the active ingredient letrozole, an aromatase inhibitor used to treat hormone receptor‑positive breast cancer in postmenopausal women. By lowering estrogen levels, it helps slow or stop the growth of estrogen‑dependent tumors as part of endocrine therapy.

Letrozole selectively blocks the aromatase enzyme, which converts androgens into estrogens in peripheral tissues. Inhibition of this enzyme reduces circulating estrogen, depriving estrogen‑dependent cancer cells of a key growth signal and thereby inhibiting tumor progression.

The dosage of Letrozole Alter is determined by the prescribing physician based on the patient’s clinical condition, treatment setting and individual factors. Only a qualified healthcare professional should set the dose and schedule.

Letrozole is classified as pregnancy category X, meaning it is contraindicated in pregnancy because it can cause fetal harm. It is also not recommended for breastfeeding mothers, as it may be excreted in milk and affect the infant.

To request Letrozole Alter, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Letrozole belongs to the aromatase‑inhibitor class, which directly reduces estrogen synthesis, unlike selective estrogen receptor modulators such as tamoxifen that block estrogen receptors. In postmenopausal patients, aromatase inhibitors like letrozole often show superior disease‑free survival in certain settings, but the choice depends on individual patient factors and physician judgment.

Letrozole Alter tablets should be stored at ambient temperature, preferably below 25 °C. Keep them in the original container, protect from moisture and direct sunlight, and ensure they are out of reach of children.

Letrozole Alter is taken orally, usually as a single tablet swallowed with water. It is typically taken once daily, at the same time each day, and may be taken with or without food as directed by the prescribing clinician.

Serious risks include severe liver injury, bone fractures due to decreased bone mineral density, pulmonary embolism, and rare anaphylactic reactions. Patients should be monitored regularly for liver function, bone health and any signs of thromboembolic events.

Letrozole Alter should not be used by pregnant women, individuals with known hypersensitivity to letrozole or any tablet component, premenopausal women (unless specifically indicated), and patients with severe liver impairment without careful medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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