Product image of Letrozole Arrow (Letrozole) supplied by GNH India

Letrozole Arrow

Active Ingredient:
Letrozole
Origin:
EU

Letrozole Arrow (Letrozole)

Letrozole, the active ingredient in Letrozole Arrow, is an aromatase inhibitor presented as an oral tablet for oral use. It is employed in the treatment of hormone receptor‑positive breast cancer in postmenopausal women, including adjuvant and metastatic settings.

GNH India supplies Letrozole Arrow as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres and pharmacies worldwide. The company adheres to EU quality standards and provides regulatory documentation for global distribution.

Manufacturer / TM Owner

Arrow Generiques

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

Letrozole is used in hormone‑driven breast cancer pathways to lower estrogen production.

  • Hormone receptor‑positive breast cancer in postmenopausal women: reduces tumor proliferation by decreasing circulating estrogen.
  • Adjuvant treatment of early‑stage breast cancer: helps prevent disease recurrence after surgery.
  • Metastatic breast cancer: provides disease control when cancer has spread beyond the breast.

How It Works

  • Letrozole selectively inhibits the aromatase enzyme, a non‑steroidal inhibitor that blocks the conversion of androgens to estrogens in peripheral tissues. By reducing systemic estrogen levels, it deprives estrogen‑dependent tumor cells of growth stimulation, thereby slowing or halting cancer progression.

Side Effects

Letrozole may cause a range of adverse reactions, which are classified by frequency and severity.

Common Side Effects

  • Hot flashes
  • Joint or muscle pain
  • Fatigue
  • Nausea
  • Headache

Serious or Rare Side Effects

  • Severe bone loss leading to fractures
  • Liver function abnormalities
  • Allergic reactions such as rash or angioedema

Precautions & Warnings

When prescribing Letrozole, clinicians should consider several safety measures and monitoring requirements.

  • Pregnancy avoidance: contraindicated in pregnancy (Category X) due to risk of fetal harm.
  • Bone health monitoring: assess bone mineral density periodically because estrogen depletion can accelerate osteoporosis.
  • Cardiovascular risk: evaluate lipid profile and blood pressure as estrogen reduction may affect cardiovascular status.
  • Liver function: check hepatic enzymes before initiation and during therapy.
  • Drug interactions: review concomitant medications for potential CYP2A6 or CYP3A4 interactions.
  • Store at ambient temperature: keep below 25 °C in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Letrozole can affect the metabolism of other medicines and may be influenced by co‑administered drugs.

Major Interactions (Avoid)

  • Strong CYP2A6 inducers (e.g., rifampicin): may markedly reduce letrozole exposure.
  • Concurrent use with estrogen‑containing hormone therapy: antagonizes therapeutic intent.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inhibitors (e.g., ketoconazole, erythromycin): may increase plasma levels.
  • Anticoagulants (e.g., warfarin): potential alteration of INR, requiring monitoring.
  • Tamoxifen: may interfere with aromatase inhibition efficacy.
  • SSRIs that affect estrogen metabolism: monitor for enhanced side effects.

Frequently Asked Questions

Letrozole Arrow contains the aromatase inhibitor letrozole and is indicated for the treatment of hormone receptor‑positive breast cancer in postmenopausal women. It is used as adjuvant therapy after surgery, as well as for controlling disease in early‑stage and metastatic settings.

Letrozole works by selectively blocking the aromatase enzyme, which converts androgens into estrogens in peripheral tissues. By inhibiting this conversion, systemic estrogen levels fall, depriving estrogen‑dependent breast cancer cells of the hormonal stimulus needed for growth.

The dosage of Letrozole Arrow is determined by the prescribing clinician based on the patient’s clinical condition, treatment stage and tolerability. Physicians typically start with the standard recommended dose, but the exact amount and schedule must be individualized and written on the prescription.

Letrozole is classified as Pregnancy Category X, meaning it is contraindicated during pregnancy because it can cause fetal harm. It is also not recommended for breastfeeding mothers, as it may be excreted in milk and affect the infant. Women of child‑bearing potential must use effective contraception.

To order Letrozole Arrow, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Letrozole is a non‑steroidal aromatase inhibitor with high potency and a long half‑life, offering once‑daily dosing. Compared with other agents such as anastrozole or exemestane, letrozole often provides slightly greater estrogen suppression, though clinical choice depends on individual patient factors, tolerability and physician preference.

Letrozole Arrow tablets should be stored at ambient temperature, preferably below 25 °C. Keep them in the original blister pack, protect from moisture and direct sunlight, and ensure the container is tightly closed to maintain product stability.

Letrozole Arrow is taken orally as a tablet. The tablet should be swallowed whole with water, and it may be taken with or without food. Patients should follow the dosing instructions provided by their healthcare professional.

The most serious risks include significant bone loss leading to fractures, liver function abnormalities, and severe allergic reactions such as rash, angioedema or anaphylaxis. Patients should report any new bone pain, jaundice, or signs of hypersensitivity to their physician promptly.

Letrozole Arrow should not be used by pregnant or breastfeeding women, premenopausal patients, individuals with severe hepatic impairment, or anyone with a known hypersensitivity to letrozole or other aromatase inhibitors. Contraindications are outlined in the prescribing information and must be reviewed before initiation.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.