Product image of Letrozole Bluefish (Letrozole) supplied by GNH India

Letrozole Bluefish

Active Ingredient:
Letrozole
Origin:
EU

Letrozole Bluefish (Letrozole)

Letrozole, the active ingredient in Letrozole Bluefish, is an aromatase inhibitor presented as an oral tablet for oral use. It is indicated for hormone receptor‑positive breast cancer in postmenopausal women, where it reduces estrogen synthesis to help control tumor growth.

GNH India supplies Letrozole Bluefish as a licensed, GDP‑compliant international pharmaceutical supplier serving oncology centres worldwide.

Manufacturer / TM Owner

Bluefish Pharmaceuticals Ab

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Indications & Clinical Uses

Letrozole is used in the management of estrogen‑dependent breast cancer, acting on the hormonal pathway that drives tumor growth.

  • Adjuvant treatment of early‑stage hormone receptor‑positive breast cancer: helps prevent disease recurrence.
  • Metastatic hormone receptor‑positive breast cancer: slows disease progression in advanced disease.
  • Postmenopausal women with estrogen‑dependent breast cancer: reduces estrogen production to inhibit tumor growth.

How It Works

  • Letrozole reversibly binds to the aromatase enzyme, blocking the conversion of androgens to estrogens in peripheral tissues. This inhibition leads to a marked reduction in circulating estrogen levels, depriving estrogen‑dependent tumor cells of a growth stimulus and thereby limiting cancer proliferation.

Side Effects

Letrozole may cause a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Hot flashes: sudden feeling of warmth, often with sweating.
  • Joint and muscle pain: aching discomfort in limbs.
  • Fatigue: persistent tiredness not relieved by rest.
  • Nausea: mild to moderate upset stomach.
  • Headache: pressure or throbbing pain in the head.
  • Dizziness: sensation of light‑headedness or unsteadiness.

Serious or Rare Side Effects

  • Severe liver injury: jaundice, dark urine, abdominal pain.
  • Bone fractures: increased risk due to reduced bone mineral density.
  • Pulmonary embolism: sudden shortness of breath, chest pain.
  • Severe allergic reactions: rash, swelling, difficulty breathing.
  • QT interval prolongation: irregular heart rhythm that may cause fainting.

Precautions & Warnings

When prescribing Letrozole, clinicians should consider several safety measures.

  • Pregnancy contraindication: drug is category X and may cause fetal harm; avoid use in pregnant women.
  • Menopausal status: indicated only for postmenopausal patients.
  • Bone health monitoring: assess bone mineral density regularly due to risk of osteoporosis.
  • Liver function monitoring: check hepatic enzymes before and during therapy.
  • Drug interaction vigilance: avoid concomitant estrogen‑containing products.
  • Store at ambient temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Letrozole can interact with other medicines, influencing its efficacy or safety.

Major Interactions (Avoid)

  • Estrogen‑containing hormone therapy: may counteract Letrozole’s effect.
  • Strong CYP2A6 inhibitors (e.g., fluvoxamine): can increase Letrozole plasma levels.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inducers (e.g., rifampin): may reduce Letrozole exposure.
  • Anticoagulants (e.g., warfarin): monitor INR as Letrozole may affect metabolism.
  • Thyroid hormone replacement: adjust dose if thyroid function changes.

Frequently Asked Questions

Letrozole Bluefish contains the active ingredient letrozole, an aromatase inhibitor used to treat hormone receptor‑positive breast cancer in postmenopausal women. It works by lowering estrogen levels, which helps slow or stop the growth of estrogen‑dependent tumors.

Letrozole blocks the aromatase enzyme, preventing the conversion of androgens into estrogen. By reducing circulating estrogen, the drug deprives estrogen‑sensitive cancer cells of a key growth signal, thereby inhibiting tumor proliferation.

The specific dose of Letrozole Bluefish is determined by the prescribing clinician based on the patient’s medical condition, treatment stage, and individual response. Healthcare professionals set the appropriate regimen according to approved guidelines.

Letrozole is classified as pregnancy category X, meaning it can cause fetal harm and is contraindicated in pregnant women. It is also not recommended for breastfeeding mothers because it may be excreted in breast milk and affect the infant.

To request Letrozole Bluefish, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Letrozole belongs to the aromatase inhibitor class, which differs from selective estrogen receptor modulators (SERMs) like tamoxifen. Aromatase inhibitors directly lower estrogen production, often providing greater efficacy in postmenopausal patients, whereas SERMs block estrogen receptors but do not reduce systemic estrogen levels.

Letrozole Bluefish should be stored at ambient temperature, below 25 °C. Keep the tablets in the original packaging, protect them from moisture and direct light, and ensure the container is tightly closed to maintain product stability.

Letrozole Bluefish is taken orally, usually as a whole tablet swallowed with water. The exact timing (e.g., with or without food) is guided by the prescribing physician, but the medication is generally absorbed well regardless of meals.

Serious risks include severe liver injury, significant bone loss leading to fractures, and rare events such as pulmonary embolism or severe allergic reactions. Patients should be monitored regularly for liver function, bone health, and any signs of cardiovascular complications.

Letrozole is contraindicated in pregnant women, premenopausal patients, and individuals with known hypersensitivity to letrozole or any component of the formulation. It should also be avoided in patients with severe liver impairment without careful medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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