Product image of Letrozole Bluefish (Letrozole) supplied by GNH India

Letrozole Bluefish

Active Ingredient:
Letrozole
Origin:
EU

Letrozole Bluefish (Letrozole)

Letrozole, the active ingredient in Letrozole Bluefish, is an aromatase inhibitor presented as a tablet for oral use. It is employed in the treatment of hormone receptor‑positive breast cancer in postmenopausal women, reducing estrogen‑driven tumor growth and improving disease outcomes.

GNH India supplies Letrozole Bluefish as a licensed, GDP‑compliant international pharmaceutical supplier serving oncology centres worldwide. The company adheres to stringent quality standards and provides reliable logistics for bulk and individual orders to hospitals, pharmacies and clinical trial sites throughout the global market.

Manufacturer / TM Owner

Bluefish Pharmaceuticals Ab

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Indications & Clinical Uses

  • Letrozole is an aromatase inhibitor used in the management of estrogen‑dependent breast cancer.
  • Hormone receptor‑positive breast cancer (adjuvant): Decreases risk of cancer recurrence after surgery.
  • Metastatic hormone receptor‑positive breast cancer (postmenopausal): Delays disease progression and extends survival.
  • Neoadjuvant therapy for estrogen‑dependent tumors (postmenopausal): Reduces tumor size before surgery.

How It Works

  • Letrozole reversibly binds to the aromatase enzyme (CYP19A1) in peripheral tissues, blocking the conversion of androstenedione and testosterone to estrone and estradiol. By lowering circulating estrogen levels, it deprives estrogen‑dependent tumor cells of a growth stimulus, thereby inhibiting proliferation and inducing apoptosis in hormone‑sensitive breast cancer. The inhibition is dose‑dependent and persists for several days after the drug is cleared, allowing sustained estrogen suppression.

Side Effects

Letrozole may cause a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Hot flashes: transient feeling of warmth and sweating.
  • Joint and muscle pain: arthralgia and myalgia.
  • Fatigue: reduced energy levels.
  • Nausea: mild gastrointestinal upset.

Serious or Rare Side Effects

  • Severe osteoporosis: increased risk of bone fractures.
  • Liver function abnormalities: elevated transaminases.
  • Cardiovascular events: thrombosis or myocardial infarction.

Precautions & Warnings

When prescribing Letrozole, clinicians should observe several precautionary measures to ensure patient safety.

  • Assess bone health: perform baseline densitometry and consider calcium/vitamin D supplementation.
  • Monitor liver enzymes: check hepatic function before initiation and periodically during therapy.
  • Evaluate cardiovascular risk: screen for hypertension, hyperlipidemia and prior thrombotic events.
  • Avoid use in pregnancy: Letrozole is contraindicated in pregnant women (Category X).
  • Adjust for drug interactions: review concomitant medications that affect CYP2A6 or CYP3A4 metabolism.
  • Store at ambient temperature: keep tablets below 25 °C in the original container, protected from moisture and light.

Avoid Interactions

Letrozole can interact with other medicines, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • Strong CYP2A6 inducers (e.g., rifampicin): may markedly reduce plasma concentrations of Letrozole.
  • Tamoxifen: concurrent use can antagonize the anti‑estrogenic effect of Letrozole.
  • Estrogen‑containing hormone therapy: diminishes therapeutic benefit and increases risk of estrogen‑related side effects.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inhibitors (e.g., ketoconazole): may increase Letrozole exposure, requiring monitoring.
  • Anticoagulants (e.g., warfarin): potential for altered INR, necessitating regular coagulation checks.
  • Antidepressants (e.g., SSRIs): may affect hormone levels; observe for clinical changes.

Frequently Asked Questions

Letrozole Bluefish is used to treat hormone receptor‑positive breast cancer in postmenopausal women. It is employed both as an adjuvant therapy after surgery to lower recurrence risk and in metastatic disease to delay progression and improve survival.

Letrozole works by reversibly inhibiting the aromatase enzyme, which converts androgens into estrogens. By suppressing estrogen production, it deprives estrogen‑dependent tumor cells of a key growth signal, thereby slowing or stopping cancer proliferation.

The exact dose of Letrozole is determined by the prescribing physician based on the patient’s clinical condition, treatment setting (adjuvant or metastatic), renal and hepatic function, and any concomitant medications. No fixed regimen is provided here.

Letrozole is classified as Pregnancy Category X, meaning it is contraindicated in pregnancy because it can cause fetal harm. Safety during breastfeeding has not been established, and the drug is generally avoided in lactating women.

To order, submit an enquiry on the Letrozole Bluefish product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Letrozole is a third‑generation aromatase inhibitor with a high potency and a long half‑life, offering consistent estrogen suppression. Compared with anastrozole or exemestane, it may provide slightly greater estrogen reduction, but choice depends on individual patient factors, tolerability and physician preference.

Letrozole tablets should be stored at ambient temperature, below 25 °C, in the original packaging to protect them from moisture and light. Keep them out of reach of children and do not use if the packaging is damaged.

Letrozole is taken orally, usually as a single tablet once daily, with or without food. Patients should follow the dosing schedule prescribed by their healthcare provider and not alter the timing without medical advice.

Serious risks include severe osteoporosis leading to fractures, liver function abnormalities, and rare cardiovascular events such as thrombosis or myocardial infarction. Patients should be monitored regularly for bone density, liver enzymes and cardiovascular health.

Letrozole should not be used by pregnant women, individuals with known hypersensitivity to the drug, patients with uncontrolled severe liver disease, or those taking contraindicated medications such as strong CYP2A6 inducers without medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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