Product image of Letrozole Bluefish (Letrozole) supplied by GNH India

Letrozole Bluefish

Active Ingredient:
Letrozole
Origin:
EU

Letrozole Bluefish (Letrozole)

Letrozole, the active ingredient in Letrozole Bluefish, is an aromatase inhibitor presented as an oral tablet for oral use. It is used to treat estrogen‑dependent breast cancer in postmenopausal patients.
GNH India supplies Letrozole Bluefish as a licensed, GDP‑compliant international pharmaceutical supplier serving oncology centres worldwide.

Manufacturer / TM Owner

Bluefish Pharmaceuticals Ab

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Indications & Clinical Uses

  • Letrozole acts on estrogen‑dependent pathways in breast cancer, providing therapeutic benefit in several clinical settings.
  • Postmenopausal breast cancer: reduces estrogen‑driven tumor growth.
  • Adjuvant therapy for early‑stage hormone‑receptor‑positive breast cancer: lowers recurrence risk.
  • Metastatic breast cancer: helps control disease progression.

How It Works

  • Letrozole selectively inhibits the aromatase enzyme, which converts adrenal and peripheral androgens into estrogens. By blocking this conversion, systemic estrogen levels decline, depriving estrogen‑dependent tumor cells of growth stimulation and thereby inhibiting cancer progression in postmenopausal patients.

Side Effects

Letrozole may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Hot flashes: transient feeling of warmth and sweating.
  • Joint and muscle pain: aching discomfort in limbs.
  • Nausea: mild to moderate upset stomach.
  • Fatigue: reduced energy and increased tiredness.

Serious or Rare Side Effects

  • Severe liver injury: jaundice, elevated enzymes.
  • Bone fractures: increased risk of osteoporosis‑related breaks.
  • Deep vein thrombosis or pulmonary embolism: swelling, pain, or shortness of breath.
  • Anaphylactic reaction: hives, swelling, airway compromise.
  • QT interval prolongation: cardiac rhythm disturbances.

Precautions & Warnings

  • Letrozole requires careful patient assessment and monitoring before and during therapy.
  • Pregnancy: contraindicated (Category X) – avoid use in pregnant women.
  • Menopause status: only for postmenopausal patients.
  • Bone health: monitor for osteoporosis, consider calcium/vitamin D supplementation.
  • Drug interactions: review concomitant medications for CYP2A6 inhibitors or inducers.
  • Liver function: assess hepatic impairment before initiating therapy.
  • Store at ambient temperature below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Letrozole can interact with several medicines, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • Strong CYP2A6 inhibitors: may increase letrozole plasma levels.
  • Tamoxifen: antagonistic effect on estrogen suppression.
  • Estrogen replacement therapy: reduces letrozole effectiveness.

Moderate Interactions (Monitor Closely)

  • Warfarin: may alter INR and bleeding risk.
  • CYP3A4 inducers (e.g., rifampicin): may reduce letrozole exposure.
  • Selective serotonin reuptake inhibitors: potential pharmacodynamic interactions.

Frequently Asked Questions

Letrozole Bluefish contains the aromatase inhibitor letrozole and is used in the treatment of estrogen‑dependent breast cancer in postmenopausal patients, including adjuvant therapy for early‑stage disease and management of metastatic disease.

Letrozole blocks the aromatase enzyme, preventing the conversion of androgens to estrogen. This reduction in circulating estrogen deprives hormone‑sensitive breast cancer cells of a growth stimulus, thereby slowing tumor progression.

The specific dose and dosing schedule of letrozole are determined by the prescribing clinician based on the patient’s condition, treatment goals, and clinical guidelines. Patients should follow the prescriber’s instructions exactly.

Letrozole is classified as pregnancy category X, meaning it is contraindicated in pregnant women because it can cause fetal harm. It is also not recommended during breastfeeding, as it may pass into milk and affect the infant.

To request Letrozole Bluefish, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Letrozole is a third‑generation aromatase inhibitor, offering more potent estrogen suppression than earlier agents such as anastrozole. Compared with selective estrogen receptor modulators like tamoxifen, letrozole works by lowering estrogen production rather than blocking the receptor, which can be advantageous in certain postmenopausal settings.

Letrozole Bluefish should be stored at ambient temperature below 25 °C, in its original packaging, and protected from moisture. No special refrigeration is required for this oral tablet formulation.

Letrozole is taken orally, usually as a tablet swallowed with water. It is typically administered once daily, but the exact timing and any food considerations should follow the prescribing clinician’s guidance.

Serious risks include severe liver injury, bone fractures due to decreased estrogen, deep‑vein thrombosis or pulmonary embolism, anaphylactic reactions, and cardiac QT‑interval prolongation. Patients should be monitored regularly for these events, especially if they have pre‑existing risk factors.

Letrozole should not be used by pregnant or breastfeeding women, premenopausal patients, individuals with severe hepatic impairment, or patients with known hypersensitivity to letrozole or any of its excipients.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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