Product image of Letrozole Cristers (Letrozole) supplied by GNH India

Letrozole Cristers

Active Ingredient:
Letrozole
Origin:
EU

Letrozole Cristers (Letrozole)

Letrozole, the active ingredient in Letrozole Cristers, is an aromatase inhibitor presented as an oral tablet for oral use. It is employed in the treatment of hormone‑receptor positive breast cancer in postmenopausal women.
GNH India supplies Letrozole Cristers as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Sun Pharmaceutical Industries Europe B.V.

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Indications & Clinical Uses

Letrozole is an aromatase inhibitor used in the management of estrogen‑dependent breast cancer.

  • Hormone receptor‑positive breast cancer (postmenopausal): reduces tumor growth and disease progression.
  • Advanced breast cancer (postmenopausal): delays disease progression and extends survival.
  • Adjuvant therapy for early‑stage breast cancer (postmenopausal): lowers risk of recurrence after surgery.

How It Works

  • Letrozole selectively inhibits the aromatase enzyme (CYP19A1), which converts adrenal and peripheral androgens into estrogens. By blocking this conversion, systemic estrogen concentrations fall, depriving estrogen‑dependent tumor cells of a growth stimulus and thereby inhibiting proliferation.

Side Effects

Letrozole may cause a range of adverse reactions.

Common Side Effects

  • Hot flashes: sudden feeling of warmth and sweating.
  • Joint and muscle pain: aching in joints or muscles.
  • Fatigue: persistent tiredness not relieved by rest.
  • Nausea: upset stomach with urge to vomit.

Serious or Rare Side Effects

  • Severe liver injury: jaundice, elevated liver enzymes.
  • Bone fracture: increased risk of osteoporosis‑related fractures.
  • Pulmonary embolism: sudden shortness of breath and chest pain.

Precautions & Warnings

Use of Letrozole requires careful clinical monitoring.

  • Pregnancy avoidance: contraindicated in pregnancy (Category X).
  • Bone health monitoring: assess risk of osteoporosis and consider calcium/vitamin D supplementation.
  • Cardiovascular assessment: evaluate history of thromboembolic disease before initiating therapy.
  • Liver function: monitor hepatic enzymes periodically.
  • Drug interactions: review all concomitant medications for potential interactions.
  • Store at ambient temperature: keep below 25°C, protect from moisture and light.

Avoid Interactions

Letrozole can interact with several medicines, altering efficacy or safety.

Major Interactions (Avoid)

  • Estrogen‑containing hormone therapy: may counteract Letrozole’s effect.
  • Tamoxifen: antagonistic action reduces therapeutic benefit.
  • Strong CYP2A6 inhibitors (e.g., fluvoxamine): increase Letrozole plasma levels.

Moderate Interactions (Monitor Closely)

  • CYP2A6 inducers (e.g., rifampicin): may lower Letrozole concentrations.
  • Warfarin: potential alteration of anticoagulant effect.
  • SSRIs (e.g., fluoxetine): possible increase in side‑effect intensity.

Frequently Asked Questions

Letrozole Cristers contains letrozole, an aromatase inhibitor indicated for the treatment of hormone‑receptor positive breast cancer in postmenopausal women, including advanced and adjuvant settings.

Letrozole blocks the aromatase enzyme, preventing the conversion of androgens to estrogen. The resulting drop in estrogen levels deprives estrogen‑dependent tumor cells of a growth signal, inhibiting their proliferation.

The prescribed dose of letrozole is determined by the treating physician based on the individual’s clinical condition and treatment protocol. Patients should follow the prescriber’s instructions precisely.

Letrozole is classified as pregnancy category X, meaning it is contraindicated in pregnancy due to potential fetal harm. It is also not recommended for breastfeeding women because it may pass into breast milk.

Enquiries can be submitted on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and import documentation.

Letrozole, as an aromatase inhibitor, lowers estrogen production, whereas drugs like tamoxifen act as selective estrogen receptor modulators. In postmenopausal patients, aromatase inhibitors such as letrozole often provide superior disease‑free survival compared with tamoxifen.

Letrozole tablets should be stored at ambient temperature, below 25 °C, in the original packaging to protect them from moisture and light. Keep the container tightly closed and out of reach of children.

Letrozole Cristers is taken orally, usually once daily, with or without food, as directed by the prescribing clinician. Swallow the tablet whole with a glass of water.

Serious risks include severe liver injury, bone fractures due to decreased bone mineral density, and rare thromboembolic events such as pulmonary embolism. Patients should report any signs of liver dysfunction, unexplained bone pain, or sudden shortness of breath.

Letrozole is contraindicated in pregnant women, women who are not postmenopausal, and patients with known hypersensitivity to letrozole or any component of the formulation. Caution is advised in individuals with severe liver disease or a history of thromboembolic disorders.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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