Product image of Letrozole Evolugen (Letrozole) supplied by GNH India

Letrozole Evolugen

Active Ingredient:
Letrozole
Origin:
EU

Letrozole Evolugen (Letrozole)

Letrozole, the active ingredient in Letrozole Evolugen, is an aromatase inhibitor presented as an oral tablet for oral use. It belongs to the antineoplastic hormone therapy class and selectively inhibits estrogen synthesis, reducing circulating estrogen levels. The medication is prescribed for hormone receptor‑positive breast cancer in postmenopausal women and is taken under medical supervision.

GNH India supplies Letrozole Evolugen as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres, pharmacies and clinics worldwide, ensuring product quality, traceability and regulatory compliance for global distribution.

Manufacturer / TM Owner

Evolupharm

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

  • Letrozole Evolugen is an aromatase inhibitor used in the management of breast cancer that depends on estrogen signaling.
  • Hormone receptor‑positive breast cancer (early stage): reduces recurrence risk when given as adjuvant therapy.
  • Metastatic breast cancer: slows disease progression in postmenopausal patients.
  • Adjuvant therapy for early‑stage disease: improves disease‑free survival after surgery.

How It Works

  • Letrozole selectively binds to and inhibits the aromatase enzyme, which converts androgens to estrogens in peripheral tissues. By blocking this conversion, systemic estrogen levels decline, depriving estrogen‑dependent tumor cells of a growth stimulus, thereby inhibiting proliferation of hormone‑sensitive breast cancer cells.

Side Effects

Letrozole may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Hot flashes: sudden feeling of warmth and sweating.
  • Joint or muscle pain: aching in limbs or back.
  • Fatigue: persistent tiredness.
  • Nausea: upset stomach, sometimes with vomiting.
  • Headache: mild to moderate intensity.
  • Dizziness: light‑headed sensation.

Serious or Rare Side Effects

  • Bone fractures: increased risk of osteoporosis‑related breaks.
  • Deep vein thrombosis or pulmonary embolism: clot formation in veins.
  • Severe liver injury: jaundice, elevated enzymes.
  • Allergic reactions: rash, swelling, anaphylaxis.
  • Elevated cholesterol: significant lipid changes.
  • Cardiovascular events: heart attack or stroke in susceptible patients.

Precautions & Warnings

  • Before initiating Letrozole therapy, clinicians should evaluate patient‑specific risk factors.
  • Monitor bone density: assess osteoporosis risk and consider supplementation.
  • Assess liver function: obtain baseline tests and repeat periodically.
  • Check cardiovascular status: watch for signs of thromboembolic disease.
  • Avoid use in pregnancy: drug is contraindicated for pregnant women.
  • Store below 25°C: keep in the original pack, protect from moisture and direct sunlight.

Avoid Interactions

Letrozole can interact with several medicines, altering its effectiveness or safety.

Major Interactions (Avoid)

  • Concurrent estrogen replacement therapy: antagonizes Letrozole’s action.
  • Strong CYP3A4 inducers (e.g., rifampin): may markedly reduce plasma concentrations.
  • Strong CYP2C19 inhibitors (e.g., fluconazole): can increase Letrozole exposure.

Moderate Interactions (Monitor Closely)

  • Tamoxifen: Letrozole may diminish its metabolic activation.
  • Warfarin: enhanced anticoagulant effect, requiring INR monitoring.
  • Statins: potential increase in statin‑related muscle toxicity.

Frequently Asked Questions

Letrozole Evolugen is prescribed for hormone receptor‑positive breast cancer in postmenopausal women. It is used both as an adjuvant treatment to lower recurrence risk after surgery and for managing metastatic disease by slowing tumor progression.

Letrozole works by selectively inhibiting the aromatase enzyme, which converts adrenal androgens into estrogen. By reducing estrogen production, the drug deprives estrogen‑dependent breast cancer cells of a key growth signal, thereby limiting tumor growth.

The dose of letrozole is determined by the prescribing clinician based on the patient’s condition, treatment setting, and clinical guidelines. Healthcare professionals adjust the regimen to achieve optimal therapeutic effect while monitoring safety.

Letrozole is contraindicated in pregnancy because it can interfere with fetal development. Safety during breastfeeding has not been established, and the drug is generally avoided in lactating women unless the benefits outweigh the risks.

To request Letrozole Evolugen, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Letrozole, an aromatase inhibitor, reduces estrogen synthesis, whereas drugs like tamoxifen act as estrogen receptor modulators. In postmenopausal patients, aromatase inhibitors such as letrozole often provide greater disease‑free survival benefits compared with tamoxifen, though side‑effect profiles differ.

Letrozole tablets should be stored below 25 °C in their original container, protected from moisture and direct light. Maintaining these conditions preserves potency and ensures the medication remains stable throughout its shelf life.

Letrozole is taken orally, usually as a tablet swallowed with water. The medication is absorbed through the gastrointestinal tract and reaches systemic circulation, where it exerts its aromatase‑inhibiting effect.

Serious risks include bone fractures due to decreased estrogen, thromboembolic events such as deep‑vein thrombosis or pulmonary embolism, severe liver injury, and rare allergic reactions. Patients should be monitored regularly for these complications.

Letrozole should not be used by pregnant women, individuals with known hypersensitivity to the drug, or patients with uncontrolled severe liver disease. Clinicians also exercise caution in patients with a history of osteoporosis or thromboembolic disorders.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Related Products

Other formulations containing Letrozole

A

A
A

A
A

A
A

A

Browse all products →

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Regulatory recognitions

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.

SGS GSDP Certification

GSDP Compliant from SGS

URS ISO 9001

URS ISO 9001 Certification

FDA Maharashtra

Licensed by FDA Maharashtra

IEC License DGFT

IEC License issued by DGFT