Product image of Letrozole Glenmark (Letrozole) supplied by GNH India

Letrozole Glenmark

Active Ingredient:
Letrozole
Origin:
EU

Letrozole Glenmark (Letrozole)

Letrozole, the active ingredient in Letrozole Glenmark, is an aromatase inhibitor presented as an oral tablet for oral use. It is employed in the treatment of hormone receptor‑positive breast cancer in postmenopausal women and works by selectively inhibiting the aromatase enzyme, reducing estrogen production that can fuel tumor growth.

GNH India supplies Letrozole Glenmark as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres, pharmacies and clinics worldwide, ensuring quality and regulatory compliance across all markets and adhering to stringent international quality standards.

Manufacturer / TM Owner

Glenmark Pharmaceuticals Europe Limited

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Indications & Clinical Uses

Letrozole acts on the estrogen synthesis pathway and is indicated for hormone‑dependent breast cancer.

  • Hormone receptor‑positive breast cancer (postmenopausal): Reduces tumor progression by lowering estrogen levels.
  • Adjuvant therapy for early‑stage hormone receptor‑positive breast cancer: Decreases risk of disease recurrence after surgery.
  • Metastatic hormone receptor‑positive breast cancer (postmenopausal): Improves disease control in advanced disease settings.

How It Works

  • Letrozole selectively binds to the aromatase enzyme (CYP19A1) in peripheral tissues, inhibiting the conversion of androstenedione and testosterone to estrone and estradiol. By blocking this final step of estrogen biosynthesis, systemic estrogen concentrations fall, depriving estrogen‑dependent tumor cells of a growth stimulus. The inhibition is reversible and dose‑dependent, providing a targeted hormonal blockade in postmenopausal patients.

Side Effects

Letrozole may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Hot flashes: Sudden feeling of warmth and sweating.
  • Joint and muscle pain: Discomfort in muscles and joints.
  • Fatigue: Persistent tiredness.
  • Nausea: Feeling of sickness.
  • Headache: Mild to moderate pain.
  • Dizziness: Light‑headed sensation.

Serious or Rare Side Effects

  • Severe liver injury: Potential hepatic dysfunction.
  • Deep vein thrombosis or pulmonary embolism: Blood clot formation.
  • Bone fracture: Increased risk due to reduced estrogen.
  • Allergic reactions (anaphylaxis): Severe hypersensitivity.
  • Cardiovascular events: Heart‑related complications.

Precautions & Warnings

Before initiating Letrozole, several safety considerations should be reviewed.

  • Monitor bone mineral density: Risk of osteoporosis and fractures.
  • Assess liver function: Potential hepatotoxicity requires periodic testing.
  • Evaluate cardiovascular status: Increased risk of thromboembolic events.
  • Avoid use in pregnancy: Classified as Category X due to teratogenic risk.
  • Store at ambient temperature below 25°C: Keep in the original pack, protect from moisture.

Avoid Interactions

Letrozole can interact with other medicines, requiring careful management.

Major Interactions (Avoid)

  • Strong CYP3A4 inducers (e.g., rifampicin): May markedly reduce Letrozole effectiveness.
  • Tamoxifen: May antagonize the hormonal blockade.
  • Estrogen replacement therapy: Counteracts Letrozole’s action.

Moderate Interactions (Monitor Closely)

  • Anticoagulants (e.g., warfarin): May increase bleeding risk.
  • Selective serotonin reuptake inhibitors (e.g., fluoxetine): May affect metabolism.
  • Statins: Possible alteration of plasma levels.

Frequently Asked Questions

Letrozole Glenmark is prescribed for the treatment of hormone receptor‑positive breast cancer in postmenopausal women. It is used in both early‑stage (adjuvant) settings to reduce recurrence risk and in metastatic disease to help control tumor growth.

Letrozole works by selectively inhibiting the aromatase enzyme, which is responsible for converting androgens into estrogens. By blocking this conversion, systemic estrogen levels drop, depriving estrogen‑dependent cancer cells of a key growth stimulus.

The dose of Letrozole Glenmark is determined by the prescribing healthcare professional based on the patient’s clinical condition, treatment goals, and relevant guidelines. The prescriber will decide the appropriate strength and dosing schedule for each individual.

Letrozole is classified as Pregnancy Category X, meaning it is contraindicated in pregnancy due to known teratogenic risk. It is also not recommended for use while breastfeeding because it may pass into breast milk and affect the infant.

To order Letrozole Glenmark, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request trade or institutional credentials before providing pricing, availability, shipping details and necessary import documentation.

Letrozole, anastrozole and exemestane belong to the same class of aromatase inhibitors. Letrozole is often chosen for its potent and selective inhibition of aromatase, which may provide slightly greater estrogen suppression. However, individual response, side‑effect profile and physician preference guide the selection among these agents.

Letrozole tablets should be stored at ambient temperature below 25 °C, kept in the original packaging, and protected from moisture and direct sunlight. Do not store in a refrigerator or freezer, and keep out of reach of children.

Letrozole is taken orally, usually as a tablet swallowed whole with water. It can be taken with or without food, and the dosing schedule is set by the prescribing clinician, typically once daily.

Serious risks include severe liver injury, deep vein thrombosis or pulmonary embolism, significant bone loss leading to fractures, and rare allergic reactions such as anaphylaxis. Patients should be monitored regularly for signs of these conditions and report any concerning symptoms promptly.

Letrozole should not be used by pregnant women, individuals with known hypersensitivity to the drug, patients with severe liver impairment, or those with uncontrolled cardiovascular disease. It is also contraindicated in patients receiving estrogen replacement therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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