Product image of Letrozole Teva (Letrozole) supplied by GNH India

Letrozole Teva

Active Ingredient:
Letrozole
Origin:
EU

Letrozole Teva (Letrozole)

Letrozole, the active ingredient in Letrozole Teva, is an aromatase inhibitor presented as a tablet for oral use. It reduces estrogen synthesis and is indicated for the treatment of hormone receptor‑positive breast cancer in postmenopausal women. By inhibiting the aromatase enzyme, Letrozole lowers circulating estrogen levels, thereby limiting the growth stimulus for estrogen‑dependent tumor cells.

GNH India supplies Letrozole Teva as a licensed, GDP‑compliant international pharmaceutical supplier serving oncology centres, hospitals, pharmacies and clinics worldwide, complying with European Union pharmacopeial standards and strict distribution protocols.

Manufacturer / TM Owner

Teva Pharma Belgium N.V./S.A

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Indications & Clinical Uses

Letrozole is an aromatase inhibitor used in the management of estrogen‑dependent breast cancer.

  • Hormone receptor‑positive breast cancer (postmenopausal): Reduces tumor growth by lowering systemic estrogen levels.
  • Adjuvant therapy for early‑stage breast cancer (postmenopausal): Decreases risk of disease recurrence after surgery.
  • Metastatic breast cancer (postmenopausal): Improves disease control and prolongs progression‑free survival.

How It Works

  • Letrozole reversibly binds to the aromatase enzyme (CYP19A1) in peripheral tissues, blocking the conversion of androstenedione and testosterone to estrone and estradiol. This inhibition markedly reduces circulating estrogen concentrations, depriving estrogen‑dependent tumor cells of a growth stimulus and thereby slowing or halting tumor progression. The effect is dose‑dependent and persists as long as the drug is present in plasma, allowing clinicians to achieve sustained estrogen suppression without the need for surgical oophorectomy.

Side Effects

Letrozole may cause a range of adverse reactions, which are generally categorized by frequency and severity.

Common Side Effects

  • Hot flashes: Sudden feeling of warmth and sweating.
  • Joint and muscle pain: Arthralgia and myalgia affecting mobility.
  • Fatigue: Persistent tiredness not relieved by rest.
  • Nausea: Mild to moderate upset stomach.
  • Headache: Persistent head pain.

Serious or Rare Side Effects

  • Severe liver injury: Elevated transaminases or hepatic failure.
  • Bone fracture: Increased risk due to reduced estrogen.
  • Thromboembolic events: Deep vein thrombosis or pulmonary embolism.
  • Allergic reaction: Rash, itching, or anaphylaxis.

Precautions & Warnings

When prescribing Letrozole, clinicians should consider several precautionary measures to minimise risks.

  • Monitor bone density: Assess risk of osteoporosis and consider calcium/vitamin D supplementation.
  • Evaluate liver function: Perform baseline and periodic liver enzyme tests.
  • Assess cardiovascular risk: Review history of thromboembolic disease before initiation.
  • Avoid use in premenopausal women: Hormonal status must be confirmed as postmenopausal.
  • Use caution in patients with severe osteoporosis: Consider alternative therapy if fracture risk is high.
  • Store at room temperature: Keep in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Letrozole can interact with other medicines, altering its efficacy or increasing toxicity.

Major Interactions (Avoid)

  • Strong CYP3A4 inducers (e.g., rifampin, carbamazepine): Decrease Letrozole plasma levels, reducing effectiveness.
  • Anticoagulants (warfarin): May enhance anticoagulant effect, increasing bleeding risk.
  • Tamoxifen: Combined use can antagonize therapeutic benefit.

Moderate Interactions (Monitor Closely)

  • Selective serotonin reuptake inhibitors (SSRIs): May increase risk of bone loss.
  • Cholesterol‑lowering agents (statins): Potential for altered metabolism, monitor liver function.

Frequently Asked Questions

Letrozole Teva is used to treat hormone receptor‑positive breast cancer in postmenopausal women. By lowering estrogen levels, it helps slow or stop the growth of estrogen‑dependent tumor cells, making it a key component of adjuvant, neoadjuvant, and metastatic breast cancer therapy.

Letrozole works by reversibly inhibiting the aromatase enzyme (CYP19A1), which converts androgens into estrogen. This inhibition reduces circulating estrogen concentrations, depriving estrogen‑dependent cancer cells of a growth signal and thereby limiting tumor proliferation.

The prescribed dose of Letrozole is determined by the treating physician based on the patient’s clinical condition and therapeutic goals. In clinical practice, a common starting regimen is 2.5 mg taken orally once daily, but exact dosing should follow the prescriber’s instructions.

Letrozole is contraindicated during pregnancy and is not recommended for breastfeeding mothers. There is insufficient safety data, and the drug can interfere with fetal development by altering estrogen levels. Women of child‑bearing potential should use effective contraception while on therapy.

To order Letrozole Teva, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request verification of trade or institutional credentials before providing pricing, availability, shipping details and import documentation.

Letrozole belongs to the aromatase inhibitor class, similar to anastrozole and exemestane. Compared with anastrozole, Letrozole has a slightly longer half‑life and may achieve more consistent estrogen suppression, but clinical outcomes are comparable. Choice of agent often depends on physician preference, patient tolerance and specific safety considerations.

Letrozole Teva tablets should be stored at room temperature, below 25 °C, in the original blister pack to protect them from moisture and light. Keep the product out of reach of children and avoid storing in damp or excessively hot environments.

Letrozole is administered orally as a tablet. Patients should swallow the tablet whole with a glass of water, with or without food, once daily as directed by their healthcare provider.

The most serious risks associated with Letrozole include severe liver injury, increased risk of bone fractures due to estrogen depletion, and thromboembolic events such as deep‑vein thrombosis or pulmonary embolism. Patients should report any signs of liver dysfunction, severe bone pain, or sudden swelling in the limbs to their physician promptly.

Letrozole should not be used in premenopausal women, patients with severe hepatic impairment, or individuals with a history of serious bone fractures or uncontrolled thromboembolic disease. It is also contraindicated during pregnancy and breastfeeding.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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