Product image of Letrozole Teva (Letrozole) supplied by GNH India

Letrozole Teva

Active Ingredient:
Letrozole
Origin:
EU

Letrozole Teva (Letrozole)

Letrozole, the active ingredient in Letrozole Teva, is an aromatase inhibitor presented as a tablet for oral use. It is employed to lower estrogen levels and is indicated for hormone receptor‑positive breast cancer in postmenopausal women and is commonly prescribed in endocrine therapy protocols.

GNH India supplies Letrozole Teva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres, pharmacies and clinics worldwide. The company follows stringent quality standards and offers reliable sourcing for oncology treatment regimens across global markets.

Manufacturer / TM Owner

Teva Pharma B.V.

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Indications & Clinical Uses

Letrozole Teva is an aromatase inhibitor used in the management of estrogen‑driven breast cancer conditions.

  • Hormone receptor‑positive breast cancer (postmenopausal): Reduces estrogen‑driven tumor growth.
  • Metastatic breast cancer (postmenopausal): Delays disease progression.
  • Adjuvant therapy for early‑stage breast cancer (postmenopausal): Decreases risk of recurrence.

How It Works

  • Letrozole selectively binds to the aromatase enzyme, blocking the conversion of adrenal and peripheral androgens into estrogens. By suppressing estrogen synthesis, circulating estrogen concentrations fall, limiting stimulation of estrogen receptors in breast tissue and thereby inhibiting the growth of hormone‑dependent tumor cells.

Side Effects

Common Side Effects

  • Hot flashes: Sudden feeling of warmth and sweating.
  • Joint pain: Discomfort or stiffness in joints.
  • Fatigue: Persistent tiredness not relieved by rest.
  • Nausea: Queasy sensation often accompanied by an urge to vomit.

Serious or Rare Side Effects

  • Severe liver injury: Jaundice, elevated liver enzymes, or hepatic failure.
  • Bone fracture: Increased risk due to reduced bone mineral density.
  • Deep vein thrombosis: Swelling, pain, and redness in the leg.
  • Severe allergic reaction: Rash, swelling, difficulty breathing, or anaphylaxis.

Precautions & Warnings

Before initiating therapy, clinicians should consider several safety measures.

  • Monitor liver function: Assess hepatic enzymes prior to and during treatment.
  • Assess bone health: Evaluate bone mineral density and consider calcium/vitamin D supplementation.
  • Evaluate cardiovascular risk: Watch for signs of thromboembolic events.
  • Avoid use in pregnancy: Contraindicated (Category X).
  • Store at ambient temperature below 25°C: Keep in the original pack, protect from moisture.

Avoid Interactions

Letrozole may interact with several medications that affect its metabolism or therapeutic effect.

Major Interactions (Avoid)

  • Concurrent estrogen replacement therapy: May reduce letrozole efficacy.
  • Strong CYP2A6 inhibitors: Can increase letrozole plasma concentrations.

Moderate Interactions (Monitor Closely)

  • Tamoxifen: Potential antagonistic effect on estrogen pathways.
  • Warfarin: May alter INR and bleeding risk.
  • CYP3A4 inducers: May decrease letrozole exposure and effectiveness.

Frequently Asked Questions

Letrozole Teva is used to treat hormone receptor‑positive breast cancer in postmenopausal women. It works by lowering estrogen levels, which helps to slow or stop the growth of estrogen‑dependent tumors.

Letrozole inhibits the aromatase enzyme, which is responsible for converting androgens into estrogen. By blocking this conversion, letrozole reduces circulating estrogen, decreasing stimulation of estrogen receptors in breast cancer cells.

The dosage of letrozole is determined by the prescribing healthcare professional based on the patient’s condition, weight, and treatment protocol. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Letrozole is classified as pregnancy category X, meaning it is contraindicated in pregnancy because it can cause fetal harm. It is also not recommended for breastfeeding mothers as it may pass into breast milk.

To order Letrozole Teva, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and necessary import documentation.

Letrozole is a third‑generation aromatase inhibitor with a high potency and a long half‑life, offering consistent estrogen suppression. Compared with earlier agents such as anastrozole or exemestane, letrozole often provides a slightly stronger estrogen reduction, though clinical choice depends on individual patient factors.

Letrozole Teva should be stored at ambient temperature below 25 °C, in its original packaging, and protected from moisture and direct sunlight to maintain stability and potency.

Letrozole is taken orally, usually as a tablet swallowed with water. It is typically taken once daily, at the same time each day, unless the prescriber advises a different schedule.

Serious risks include severe liver injury, bone fractures due to decreased bone density, and rare thromboembolic events such as deep‑vein thrombosis or pulmonary embolism. Patients should be monitored regularly for signs of these conditions.

Letrozole should not be used by pregnant women, individuals with known hypersensitivity to the drug, or patients with severe liver impairment. It is also contraindicated in patients who are premenopausal or who require estrogen therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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