Product image of Letrozole Teva (Letrozole) supplied by GNH India

Letrozole Teva

Active Ingredient:
Letrozole
Origin:
EU

Letrozole Teva (Letrozole)

Letrozole, the active ingredient in Letrozole Teva, is an aromatase inhibitor presented as an oral tablet for oral use. It is employed in the hormonal management of estrogen‑dependent breast cancer in postmenopausal women, reducing peripheral estrogen synthesis and is prescribed as part of adjuvant or metastatic therapy protocols.

GNH India supplies Letrozole Teva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres, pharmacies and clinics worldwide with a focus on quality assurance and regulatory compliance across EU and global markets.

Manufacturer / TM Owner

Teva Santé

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Indications & Clinical Uses

Letrozole is used in hormone‑dependent breast cancer pathways to lower estrogen levels.

  • Postmenopausal hormone receptor‑positive breast cancer: reduces tumor growth and recurrence risk.
  • Advanced or metastatic breast cancer in postmenopausal women: slows disease progression.
  • Adjuvant therapy after surgery for estrogen‑dependent breast cancer: helps prevent disease return.

How It Works

  • Letrozole selectively and reversibly inhibits the aromatase enzyme (CYP19A1), which converts androstenedione and testosterone into estrone and estradiol. By blocking this peripheral conversion, systemic estrogen concentrations decline, depriving estrogen‑dependent tumor cells of a growth stimulus. The inhibition is dose‑dependent and persists for the duration of drug exposure, providing sustained estrogen suppression in postmenopausal patients. This mechanism underlies its therapeutic effect in estrogen‑sensitive malignancies.

Side Effects

Letrozole may cause a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Hot flashes: sudden feeling of warmth and sweating.
  • Joint and muscle pain: arthralgia or myalgia.
  • Fatigue: persistent tiredness.
  • Nausea: upset stomach and urge to vomit.

Serious or Rare Side Effects

  • Severe osteoporosis: increased risk of bone fractures.
  • Thromboembolic events: deep vein thrombosis or pulmonary embolism.
  • Liver function abnormalities: elevated transaminases or hepatitis.

Precautions & Warnings

When prescribing Letrozole, clinicians should consider several safety measures.

  • Monitor bone mineral density: assess risk of osteoporosis regularly.
  • Assess cardiovascular status: watch for signs of thrombosis or hypertension.
  • Check liver function tests: evaluate hepatic enzymes before and during therapy.
  • Avoid use in pregnancy: teratogenic potential unknown; contraindicated.
  • Inform patients about hot flashes and joint pain: provide supportive measures.
  • Store at ambient temperature below 25°C: keep in original packaging, protect from moisture and light.

Avoid Interactions

Letrozole can interact with other medicines, requiring attention to avoid reduced efficacy or increased toxicity.

Major Interactions (Avoid)

  • Concurrent use of estrogen replacement therapy: negates drug effect.
  • Strong CYP3A4 inducers (e.g., rifampin, carbamazepine): markedly reduce plasma levels.

Moderate Interactions (Monitor Closely)

  • Anticoagulants (warfarin): may increase bleeding risk; monitor INR.
  • Selective serotonin reuptake inhibitors (SSRIs): may exacerbate nausea.
  • Tamoxifen: antagonistic effect on estrogen pathways; avoid combined use.

Frequently Asked Questions

Letrozole Teva is indicated for the treatment of estrogen‑dependent breast cancer in postmenopausal women. It is used both as a primary therapy for advanced disease and as an adjuvant to reduce the risk of recurrence after surgery.

Letrozole works by selectively and reversibly inhibiting the aromatase enzyme, which converts androgens into estrogens. This inhibition lowers circulating estrogen levels, depriving estrogen‑sensitive tumor cells of a key growth signal.

The dosage of Letrozole is determined by the prescribing clinician based on the patient’s condition, treatment setting, and clinical guidelines. Patients should follow the dose and schedule provided by their healthcare professional.

Letrozole is classified as contraindicated during pregnancy because its effects on fetal development are unknown. It should not be used by breastfeeding mothers, as it may pass into milk and affect the infant.

To order Letrozole Teva, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Letrozole is a third‑generation aromatase inhibitor with a high potency and a long half‑life, offering consistent estrogen suppression. Compared with earlier agents such as anastrozole, Letrozole often provides a slightly stronger reduction in estrogen levels, which can translate into improved disease control in certain patient populations.

Letrozole tablets should be stored at ambient temperature below 25 °C, in the original container, protected from moisture and light. Keep the product out of reach of children and avoid storing in areas with high humidity or direct sunlight.

Letrozole is taken orally, usually as a whole tablet swallowed with water. It is typically administered once daily, with or without food, as directed by the treating physician.

The most serious risks include severe osteoporosis leading to fractures, thromboembolic events such as deep‑vein thrombosis or pulmonary embolism, and significant liver function abnormalities. Patients should be monitored regularly for bone health, cardiovascular symptoms and hepatic markers.

Letrozole should not be used by premenopausal women, pregnant or nursing individuals, and patients with known hypersensitivity to the drug or its excipients. Caution is also advised in patients with severe liver disease or uncontrolled cardiovascular conditions.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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