Product image of Letrozole Teva (Letrozole) supplied by GNH India

Letrozole Teva

Active Ingredient:
Letrozole
Origin:
EU

Letrozole Teva (Letrozole)

Letrozole, the active ingredient in Letrozole Teva, is a aromatase inhibitor presented as an oral tablet for oral use. It treats hormone receptor‑positive breast cancer in postmenopausal women. GNH India supplies Letrozole Teva as a licensed, GDP‑compliant international pharmaceutical supplier serving oncology centres worldwide.

Manufacturer / TM Owner

Teva Gyógyszergyár Zrt

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Indications & Clinical Uses

  • Letrozole is an aromatase inhibitor used in the management of hormone‑dependent breast cancer.
  • Hormone receptor‑positive breast cancer in postmenopausal women: reduces estrogen production to inhibit tumor growth.
  • Adjuvant treatment of early‑stage breast cancer: helps prevent recurrence after surgery.
  • Metastatic breast cancer: slows disease progression by limiting estrogen‑driven tumor growth.

How It Works

  • Letrozole selectively and non‑steroidally inhibits the aromatase enzyme, which converts androgens to estrogens in peripheral tissues. By blocking this conversion, systemic estrogen levels fall, depriving estrogen‑dependent tumor cells of a growth stimulus and thereby limiting cancer proliferation.

Side Effects

Letrozole may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Hot flashes
  • Joint and muscle pain
  • Fatigue
  • Nausea
  • Headache
  • Dizziness

Serious or Rare Side Effects

  • Severe liver injury
  • Osteoporotic fractures
  • Deep vein thrombosis or pulmonary embolism
  • Severe allergic reactions (anaphylaxis)
  • Cardiac arrhythmias (QT prolongation)
  • Hypercholesterolemia

Precautions & Warnings

  • Before initiating Letrozole therapy, clinicians should consider several safety measures.
  • Monitor bone density: assess risk of osteoporosis and consider supplementation.
  • Assess liver function: perform baseline and periodic liver enzyme tests.
  • Evaluate cardiovascular risk: watch for thromboembolic events.
  • Review concomitant medications: avoid drugs that may interact with aromatase inhibition.
  • Counsel on menopausal symptoms: discuss management of hot flashes and fatigue.
  • Store at below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Letrozole can interact with other medicines, requiring careful management.

Major Interactions (Avoid)

  • Strong CYP3A4 inducers (e.g., rifampin) may reduce efficacy.
  • Tamoxifen may antagonize aromatase inhibition.
  • Estrogen replacement therapy can counteract therapeutic effect.

Moderate Interactions (Monitor Closely)

  • CYP2C19 inhibitors (e.g., fluconazole) may increase plasma levels.
  • Anticoagulants (e.g., warfarin) may require dose adjustment.
  • Selective serotonin reuptake inhibitors (SSRIs) may affect metabolism.

Frequently Asked Questions

Letrozole Teva is indicated for the treatment of hormone receptor‑positive breast cancer in postmenopausal women. It is employed as part of adjuvant therapy to reduce the risk of recurrence after surgery and also in metastatic disease to slow tumor progression by lowering estrogen levels.

Letrozole works by selectively inhibiting the aromatase enzyme, which converts androgens into estrogens in peripheral tissues. This inhibition leads to a marked decrease in circulating estrogen, depriving estrogen‑dependent breast cancer cells of a key growth stimulus.

The dosage of Letrozole Teva is individualized by the prescribing clinician based on the patient’s clinical condition, renal and hepatic function, and treatment goals. The prescriber determines the appropriate strength and frequency, which is typically a once‑daily oral regimen.

Letrozole is contraindicated in pregnancy and breastfeeding because it can interfere with normal estrogen‑dependent development. The safety profile in these populations is unknown, and the drug should not be used by women who are pregnant, planning to become pregnant, or nursing.

To order Letrozole Teva, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams worldwide, and will request verification of trade or institutional credentials before providing pricing, availability, shipping details, and any necessary import documentation.

Letrozole belongs to the aromatase inhibitor class, similar to anastrozole and exemestane. Compared with tamoxifen, another common breast‑cancer therapy, Letrozole provides a more potent reduction in estrogen levels and is generally preferred for postmenopausal patients, whereas tamoxifen is often used in premenopausal women.

Letrozole Teva tablets should be stored at temperatures below 25 °C, in their original packaging, and protected from moisture and direct sunlight. Keep the product out of reach of children and avoid storing in areas with high humidity.

Letrozole Teva is taken orally as a tablet. The patient should swallow the tablet whole with water, and it may be taken with or without food. Consistency in the timing of each dose each day helps maintain stable drug levels.

Serious risks associated with Letrozole include severe liver injury, osteoporotic fractures, and thromboembolic events such as deep‑vein thrombosis or pulmonary embolism. Patients should also be aware of possible severe allergic reactions and cardiac rhythm disturbances, and report any concerning symptoms promptly.

Letrozole should not be used by premenopausal women, pregnant or breastfeeding individuals, patients with severe hepatic impairment, or those with known hypersensitivity to letrozole or any of its excipients. Caution is also advised for patients with a history of osteoporosis or thromboembolic disease.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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