Product image of Letrozole Teva (Letrozole) supplied by GNH India

Letrozole Teva

Active Ingredient:
Letrozole
Origin:
EU

Letrozole Teva (Letrozole)

Letrozole, the active ingredient in Letrozole Teva, is an aromatase inhibitor presented as an oral tablet for oral use. It is indicated for the treatment of estrogen‑receptor‑positive breast cancer in postmenopausal women, where it lowers estrogen synthesis to help control tumor growth. The drug works by competitively inhibiting the aromatase enzyme, thereby reducing peripheral conversion of androgens to estrogens.

GNH India supplies Letrozole Teva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Teva Pharma B.V.

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Indications & Clinical Uses

Letrozole is used in the hormonal pathway of estrogen‑dependent breast cancer.

  • Estrogen receptor‑positive breast cancer (postmenopausal): Reduces tumor progression by lowering circulating estrogen levels.
  • Adjuvant therapy for early‑stage disease: Decreases risk of recurrence after surgery and radiotherapy.
  • Metastatic breast cancer: Helps control disease spread in hormone‑responsive tumors.

How It Works

  • Letrozole selectively binds to the aromatase enzyme in peripheral tissues, blocking the conversion of androstenedione and testosterone into estrone and estradiol. By suppressing estrogen production, it diminishes estrogen‑driven proliferation of breast cancer cells, providing a targeted antineoplastic effect in postmenopausal patients.

Side Effects

Common side effects are generally mild to moderate and may affect treatment tolerability.

Common Side Effects

  • Hot flashes: Sudden feeling of warmth, often with sweating.
  • Arthralgia: Joint pain or stiffness.
  • Fatigue: Persistent tiredness not relieved by rest.
  • Nausea: Mild stomach upset.
  • Headache: Pressure or throbbing pain.
  • Insomnia: Difficulty falling or staying asleep.

Serious or Rare Side Effects

  • Severe liver injury: Jaundice, dark urine, or elevated liver enzymes.
  • Bone fracture: Increased risk of osteoporosis‑related breaks.
  • Pulmonary embolism: Sudden shortness of breath, chest pain.
  • Anaphylaxis: Rapid swelling, hives, or difficulty breathing.
  • QT interval prolongation: Potential cardiac arrhythmia.

Precautions & Warnings

Patients should be monitored for specific safety concerns before and during therapy.

  • Bone health monitoring: Assess bone mineral density periodically.
  • Liver function testing: Check hepatic enzymes at baseline and during treatment.
  • Cardiovascular assessment: Evaluate risk factors for thrombosis and embolism.
  • Pregnancy avoidance: Contraindicated in pregnancy; ensure effective contraception.
  • Menopausal symptom counseling: Discuss hot flashes and mood changes.
  • Store at below 25°C: Keep in the original packaging, protect from moisture and direct light.

Avoid Interactions

Letrozole may interact with other medicines that affect its metabolism or hormonal activity.

Major Interactions (Avoid)

  • Strong CYP3A4 inducers (e.g., rifampin, carbamazepine): Can markedly reduce letrozole exposure.
  • Exogenous estrogen therapy: May counteract the drug’s aromatase inhibition.
  • Tamoxifen: Potential antagonistic effect on estrogen pathways.

Moderate Interactions (Monitor Closely)

  • CYP2C19 inhibitors (e.g., fluconazole): May increase plasma levels modestly.
  • Warfarin: Enhanced anticoagulant effect; monitor INR.
  • Statins metabolized by CYP3A4: Observe for altered lipid‑lowering response.
  • SSRIs (e.g., fluoxetine): Possible additive effect on QT interval.
  • Antihypertensives: Monitor blood pressure as hormonal changes can influence vascular tone.

Frequently Asked Questions

Letrozole Teva is prescribed for estrogen‑receptor‑positive breast cancer in postmenopausal women. It is used as adjuvant therapy after surgery, as well as in advanced or metastatic disease to lower estrogen levels that can stimulate tumor growth.

Letrozole blocks the aromatase enzyme, which converts androgens into estrogens in peripheral tissues. By inhibiting this conversion, the drug reduces circulating estrogen, limiting the hormonal stimulus that drives growth of certain breast cancer cells.

The dosage of letrozole is determined by the prescribing physician based on the patient’s clinical condition, treatment stage, and individual health factors. Patients should follow the exact regimen provided by their healthcare professional.

Letrozole is classified as pregnancy category X, meaning it is contraindicated in pregnancy due to potential fetal harm. It is also not recommended while breastfeeding because it may pass into breast milk and affect the infant.

To place an order, submit an enquiry on the Letrozole Teva product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Letrozole is a third‑generation aromatase inhibitor with a high potency for estrogen suppression, similar to anastrozole and exemestane. Clinical studies suggest comparable efficacy, though individual patient response, side‑effect profile and physician preference may guide the choice among these agents.

Letrozole tablets should be stored at temperatures below 25 °C, in the original container, protected from moisture and direct sunlight. Keep the product out of reach of children and do not use if the packaging is damaged.

Letrozole is taken orally, usually once daily, with or without food. The tablet should be swallowed whole with water and not crushed or chewed, unless otherwise directed by a healthcare professional.

Serious risks include severe liver injury, osteoporosis‑related fractures, pulmonary embolism, anaphylactic reactions, and cardiac arrhythmias such as QT prolongation. Patients should be monitored regularly for signs of these conditions and report any concerning symptoms promptly.

Letrozole should not be used by pregnant or breastfeeding women, individuals with known hypersensitivity to the drug, or patients with severe liver impairment. It is also contraindicated in premenopausal women unless ovarian function suppression is confirmed.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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