Product image of Letrozole Teva (Letrozole) supplied by GNH India

Letrozole Teva

Active Ingredient:
Letrozole
Origin:
EU

Letrozole Teva (Letrozole)

Letrozole, the active ingredient in Letrozole Teva, is a aromatase inhibitor presented as an unknown strength/oral tablet for oral use. It treats postmenopausal estrogen receptor‑positive breast cancer in patients who have completed surgery or radiation and require endocrine therapy.

GNH India supplies Letrozole Teva as a licensed, GDP‑compliant international pharmaceutical supplier serving oncology centres worldwide. The company adheres to stringent quality standards and provides reliable sourcing for clinical use. Clients benefit from consistent batch release testing and regulatory compliance across EU markets.

Manufacturer / TM Owner

Teva Pharma B.V.

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Indications & Clinical Uses

Letrozole is used in the endocrine therapy pathway for hormone‑dependent breast cancer.

  • Postmenopausal early breast cancer: reduces risk of disease recurrence as adjuvant therapy.
  • Postmenopausal metastatic breast cancer: delays disease progression in advanced disease.
  • Hormone receptor‑positive breast cancer with ovarian suppression: provides estrogen suppression when combined with ovarian function suppression.

How It Works

  • Letrozole selectively inhibits the aromatase enzyme, which converts androgens to estrogens in peripheral tissues. By blocking this conversion, systemic estrogen levels decline, limiting the hormonal stimulation of estrogen receptor‑positive breast cancer cells and thereby inhibiting tumor growth.

Side Effects

Letrozole may cause a range of adverse reactions.

Common Side Effects

  • Hot flashes: transient episodes of increased body temperature.
  • Joint and muscle pain: mild to moderate musculoskeletal discomfort.
  • Fatigue: reduced energy levels and increased tiredness.
  • Nausea: occasional upset stomach.

Serious or Rare Side Effects

  • Severe liver injury: signs of hepatitis or jaundice.
  • Bone fracture: increased risk due to reduced estrogen.
  • Pulmonary embolism: sudden shortness of breath and chest pain.

Precautions & Warnings

Before initiating Letrozole therapy, consider the following precautions.

  • Monitor bone health: assess risk of osteoporosis and consider calcium/vitamin D supplementation.
  • Assess liver function: perform periodic liver enzyme tests.
  • Check cardiovascular status: monitor lipid profile and blood pressure.
  • Avoid use in patients with known hypersensitivity to letrozole or its excipients.
  • Store at room temperature below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Letrozole can interact with several medicines; awareness of interaction severity is essential.

Major Interactions (Avoid)

  • Estrogen replacement therapy: diminishes letrozole efficacy.
  • Strong CYP3A4 inducers (e.g., rifampin, carbamazepine): markedly reduce plasma concentrations.

Moderate Interactions (Monitor Closely)

  • Tamoxifen: antagonistic effect on estrogen pathways.
  • Warfarin: may increase INR and bleeding risk.
  • Selective serotonin reuptake inhibitors (e.g., fluoxetine): may alter letrozole metabolism.

Frequently Asked Questions

Letrozole Teva contains the active ingredient letrozole, an aromatase inhibitor indicated for the endocrine treatment of postmenopausal women with estrogen receptor‑positive breast cancer, both in the adjuvant and metastatic settings.

Letrozole blocks the aromatase enzyme, preventing the conversion of androgens to estrogen. This reduction in circulating estrogen limits the growth stimulus for estrogen‑dependent breast cancer cells, helping to control tumor progression.

The specific dose and regimen of letrozole are determined by the prescribing clinician based on the patient’s condition, treatment goals, and clinical guidelines. Patients should follow the prescriber’s instructions precisely.

Letrozole is contraindicated in pregnancy and is not recommended for use while breastfeeding because it can affect fetal and infant hormone development. Women of childbearing potential should use effective contraception during treatment.

To request Letrozole Teva, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and necessary import documentation.

Letrozole is a third‑generation aromatase inhibitor with high potency and a long half‑life, offering consistent estrogen suppression. Compared with anastrozole or exemestane, letrozole often shows slightly greater reductions in estrogen levels, though clinical choice depends on individual patient factors and tolerability.

Letrozole Teva should be stored at room temperature below 25 °C, in the original packaging, protected from moisture and direct sunlight. Do not store in bathrooms or near heat sources.

Letrozole Teva is taken orally, usually once daily, with or without food, as directed by the healthcare professional. Swallow the tablet whole with a glass of water; do not crush or chew unless instructed otherwise.

Serious risks include severe liver injury, bone fractures due to decreased estrogen, and rare thromboembolic events such as pulmonary embolism. Patients should be monitored regularly for liver function, bone health, and signs of clotting disorders.

Letrozole should not be used by individuals with known hypersensitivity to the drug or its excipients, premenopausal women not receiving ovarian suppression, pregnant or breastfeeding women, and patients with severe liver impairment without appropriate medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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