Product image of Letrozole Torrent Pharma (Uk) (Letrozole) supplied by GNH India

Letrozole Torrent Pharma (Uk)

Active Ingredient:
Letrozole
Origin:
EU

Letrozole Torrent Pharma (Uk) (Letrozole)

Letrozole, the active ingredient in Letrozole Torrent Pharma (Uk), is a aromatase inhibitor presented as an oral tablet for oral use. It is employed in the endocrine treatment of postmenopausal hormone receptor‑positive breast cancer, reducing estrogen‑driven tumor growth.

GNH India supplies Letrozole Torrent Pharma (Uk) as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres and pharmacies worldwide.

Manufacturer / TM Owner

Torrent Pharma (Uk) Ltd.

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Indications & Clinical Uses

Letrozole acts on estrogen‑dependent breast cancer pathways and is indicated for several stages of the disease.

  • Postmenopausal hormone receptor‑positive breast cancer: reduces risk of recurrence and disease progression.
  • Adjuvant treatment of early‑stage breast cancer: improves disease‑free survival after surgery.
  • Metastatic breast cancer: slows tumor growth and extends overall survival.

How It Works

  • Letrozole reversibly binds to the aromatase enzyme, inhibiting its activity and thereby blocking the conversion of androgens to estrogens. This reduction in circulating estrogen limits the hormonal stimulation of estrogen‑receptor‑positive breast cancer cells, curbing their proliferation and survival.

Side Effects

Letrozole may cause a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Hot flashes: sudden feeling of warmth and sweating.
  • Joint and muscle pain: aching in joints or muscles.
  • Fatigue: persistent tiredness.
  • Nausea: feeling of sickness or urge to vomit.

Serious or Rare Side Effects

  • Severe liver injury: elevated liver enzymes or hepatitis.
  • Bone fracture: increased risk due to reduced bone density.
  • Pulmonary embolism: blood clot in the lungs.
  • Allergic reaction: rash, swelling, or difficulty breathing.

Precautions & Warnings

Before initiating Letrozole therapy, several safety considerations should be addressed.

  • Bone health monitoring: assess bone mineral density regularly.
  • Liver function assessment: check hepatic enzymes prior to and during treatment.
  • Cardiovascular risk evaluation: review history of thromboembolic events.
  • Concomitant medication review: avoid drugs that may interfere with aromatase inhibition.
  • Store at below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Letrozole can interact with other medicines, influencing its efficacy or safety.

Major Interactions (Avoid)

  • Strong CYP3A4 inducers (e.g., rifampin): may reduce Letrozole plasma levels.
  • Estrogen‑containing hormone therapy: antagonizes therapeutic effect.
  • Tamoxifen: competitive estrogen receptor modulation.

Moderate Interactions (Monitor Closely)

  • Antifungal agents (e.g., ketoconazole): may increase Letrozole exposure.
  • Selective serotonin reuptake inhibitors: potential additive effect on QT interval.
  • Warfarin: possible alteration of anticoagulant control.

Frequently Asked Questions

Letrozole Torrent Pharma (Uk) is an oral aromatase inhibitor prescribed for postmenopausal women with hormone receptor‑positive breast cancer. It is used in both early‑stage (adjuvant) and metastatic settings to lower estrogen levels and help control tumor growth.

Letrozole blocks the aromatase enzyme, which converts androgens into estrogen. By inhibiting this conversion, circulating estrogen concentrations fall, depriving estrogen‑dependent breast cancer cells of the hormonal stimulus they need to proliferate.

The specific dose and schedule of Letrozole are determined by the prescribing clinician based on the patient’s condition, treatment stage, and overall health. Patients should follow the exact regimen provided by their healthcare professional.

Letrozole is contraindicated in pregnancy because it can affect fetal development. It is also not recommended while breastfeeding, as it may pass into breast milk and affect the infant. Women of child‑bearing potential should use effective contraception during treatment.

To request Letrozole Torrent Pharma, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and necessary import documentation.

Letrozole is a third‑generation aromatase inhibitor, offering more potent estrogen suppression than earlier agents such as anastrozole. Compared with selective estrogen receptor modulators like tamoxifen, Letrozole does not act on estrogen receptors directly, which can result in different side‑effect profiles and efficacy in postmenopausal patients.

Letrozole tablets should be stored at temperatures below 25 °C, in the original container, protected from moisture and direct light. Keep the product out of reach of children and do not use if the packaging is damaged.

Letrozole is taken orally, usually as a single tablet once daily, with or without food. Patients should swallow the tablet whole with water and avoid crushing or chewing it, unless otherwise instructed by a healthcare professional.

Serious risks include severe liver injury, bone fractures due to decreased bone mineral density, and rare thromboembolic events such as pulmonary embolism. Patients should report any signs of liver dysfunction, unexplained bone pain, or sudden shortness of breath to their physician promptly.

Letrozole is not recommended for premenopausal women, pregnant or nursing individuals, and patients with known hypersensitivity to the drug. It should also be avoided in patients with severe liver impairment or uncontrolled cardiovascular disease unless a specialist determines the benefits outweigh the risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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