Product image of Letrozole Viatris (Letrozole) supplied by GNH India

Letrozole Viatris

Active Ingredient:
Letrozole
Origin:
EU

Letrozole Viatris (Letrozole)

Letrozole, the active ingredient in Letrozole Viatris, is an aromatase inhibitor presented as an oral tablet for oral use. It reduces estrogen production and is used to treat hormone receptor‑positive breast cancer in postmenopausal women.

GNH India supplies Letrozole Viatris as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres, pharmacies and clinics worldwide. The product conforms to EU quality standards and is manufactured under GMP conditions. It is distributed through GNH India's global network, ensuring reliable supply chains and regulatory compliance for oncology treatments.

Manufacturer / TM Owner

Viatris Limited

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

Letrozole is an aromatase inhibitor used in the management of estrogen‑dependent breast cancer.

  • Hormone receptor‑positive breast cancer (postmenopausal): Reduces risk of disease recurrence and progression.
  • Metastatic breast cancer (postmenopausal): Improves disease control and prolongs survival.
  • Adjuvant therapy for early‑stage hormone‑dependent breast cancer (postmenopausal): Decreases likelihood of tumor regrowth after surgery.

How It Works

  • Letrozole reversibly binds to the aromatase enzyme, inhibiting its activity and thereby blocking the conversion of androgens to estrogens. This reduction in systemic estrogen levels limits the growth stimulus for estrogen‑dependent tumor cells, particularly in postmenopausal breast cancer patients.

Side Effects

Letrozole may cause a range of adverse reactions that vary in frequency and severity.

Common Side Effects

  • Hot flashes: Sudden feeling of warmth and sweating.
  • Arthralgia: Joint pain or stiffness.
  • Fatigue: Persistent tiredness affecting daily activities.
  • Nausea: Mild to moderate upset stomach.
  • Headache: Pressure or throbbing pain in the head.
  • Dizziness: Light‑headed sensation, especially when standing.

Serious or Rare Side Effects

  • Bone fracture: Increased risk due to reduced bone mineral density.
  • Deep vein thrombosis: Blood clot formation in deep veins.
  • Severe allergic reaction: Rash, swelling, or difficulty breathing.
  • Hepatic dysfunction: Elevated liver enzymes or jaundice.
  • QT interval prolongation: Potential cardiac rhythm disturbances.

Precautions & Warnings

Before initiating Letrozole therapy, several safety considerations should be addressed.

  • Bone health monitoring: Assess bone mineral density regularly due to risk of osteoporosis.
  • Liver function testing: Perform baseline and periodic liver enzyme assessments.
  • Cardiovascular risk evaluation: Consider history of thromboembolic events.
  • Pregnancy avoidance: Do not use in pregnant or nursing women; effective contraception required.
  • Drug interaction review: Avoid concomitant estrogen replacement therapy.
  • Store at ambient temperature: Keep below 25°C in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Letrozole can interact with other medicines, influencing its efficacy or safety.

Major Interactions (Avoid)

  • Estrogen replacement therapy: Counteracts letrozole's estrogen‑lowering effect.
  • Strong CYP3A4 inhibitors (e.g., ketoconazole): May increase letrozole plasma levels.
  • Tamoxifen: Simultaneous use can reduce therapeutic benefit.

Moderate Interactions (Monitor Closely)

  • CYP2A6 inhibitors (e.g., methoxsalen): May modestly raise letrozole concentrations.
  • Warfarin: Potential alteration of anticoagulant effect; monitor INR.
  • Cholesterol‑lowering agents (e.g., statins): Observe for any changes in lipid profile.

Frequently Asked Questions

Letrozole Viatris is used to treat hormone receptor‑positive breast cancer in postmenopausal women. It works by lowering estrogen levels, which helps slow or stop the growth of estrogen‑dependent tumor cells.

Letrozole inhibits the aromatase enzyme, preventing the conversion of androgens into estrogen. This reduction in circulating estrogen deprives hormone‑sensitive breast cancer cells of a key growth signal, thereby inhibiting tumor progression.

The dosage of letrozole is determined by the prescribing physician based on the patient’s clinical condition, treatment goals, and any relevant laboratory values. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Letrozole is contraindicated in pregnancy and its safety during breastfeeding is unknown. Women of child‑bearing potential should use effective contraception while on therapy, and breastfeeding should be avoided.

To order Letrozole Viatris, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and necessary import documentation.

Letrozole belongs to the aromatase inhibitor class, which differs from selective estrogen receptor modulators like tamoxifen. Aromatase inhibitors generally provide stronger estrogen suppression in postmenopausal patients and are often preferred in advanced or adjuvant settings, whereas tamoxifen may be used in premenopausal women.

Letrozole Viatris should be stored at ambient temperature, below 25 °C, in its original packaging. It should be kept away from moisture, direct sunlight, and excessive heat to maintain product stability.

Letrozole Viatris is taken orally, usually as a tablet swallowed with water. The medication is typically taken once daily, at the same time each day, unless the prescriber advises otherwise.

Serious risks include bone fractures due to decreased bone density, deep vein thrombosis, severe allergic reactions, and potential liver toxicity. Patients should be monitored regularly for these events and report any concerning symptoms promptly.

Letrozole should not be used by pregnant or nursing women, individuals with known hypersensitivity to letrozole or other aromatase inhibitors, and patients with severe liver impairment without careful medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Related Products

Other formulations containing Letrozole

A

A
A

A
A

A
A

A

Browse all products →

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Regulatory recognitions

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.

SGS GSDP Certification

GSDP Compliant from SGS

URS ISO 9001

URS ISO 9001 Certification

FDA Maharashtra

Licensed by FDA Maharashtra

IEC License DGFT

IEC License issued by DGFT