Product image of Letrozole Zentiva Pharma (Letrozole) supplied by GNH India

Letrozole Zentiva Pharma

Active Ingredient:
Letrozole
Origin:
EU

Letrozole Zentiva Pharma (Letrozole)

Letrozole, the active ingredient in Letrozole Zentiva Pharma, is an aromatase inhibitor presented as a tablet for oral use. It belongs to the antineoplastic hormone therapy class and is indicated for hormone receptor‑positive breast cancer in postmenopausal women.

GNH India supplies Letrozole Zentiva Pharma as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Zentiva Pharma Uk Limited

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Indications & Clinical Uses

Letrozole acts on estrogen‑dependent breast cancer pathways and is used in several clinical settings.

  • Adjuvant treatment of early‑stage hormone receptor‑positive breast cancer: reduces risk of recurrence after surgery.
  • Metastatic hormone receptor‑positive breast cancer: slows disease progression in postmenopausal women.
  • Neoadjuvant therapy for locally advanced breast cancer: shrinks tumor size before surgery.

How It Works

  • Letrozole reversibly binds to the aromatase enzyme in peripheral tissues, inhibiting its activity in a non‑competitive manner. This blocks the conversion of androstenedione and testosterone into estrone and estradiol, respectively, leading to markedly reduced circulating estrogen levels and diminished estrogen‑driven tumor proliferation in postmenopausal patients.

Side Effects

Adverse reactions may vary in frequency and severity.

Common Side Effects

  • Hot flashes
  • Joint and muscle pain
  • Fatigue
  • Nausea

Serious or Rare Side Effects

  • Severe liver injury
  • Bone fracture due to decreased bone mineral density
  • Allergic reactions such as rash, angioedema, or anaphylaxis

Precautions & Warnings

Patients should be monitored for specific safety concerns before and during therapy.

  • Bone health monitoring: assess bone mineral density and consider calcium/vitamin D supplementation.
  • Liver function assessment: perform baseline and periodic liver enzyme tests.
  • Cardiovascular risk evaluation: review history of thromboembolic events.
  • Drug interaction review: check concomitant medications that may alter letrozole exposure.
  • Patient counseling: advise on recognizing signs of serious adverse reactions.
  • Store at ambient temperature: keep in the original container, protect from moisture and heat.

Avoid Interactions

Letrozole may interact with other medicines that affect its metabolism or therapeutic effect.

Major Interactions (Avoid)

  • Strong CYP3A4 inducers (e.g., rifampin, carbamazepine): may markedly reduce letrozole exposure.
  • Estrogen replacement therapy: counteracts aromatase inhibition and diminishes efficacy.
  • Tamoxifen: antagonistic action may interfere with intended hormonal control.

Moderate Interactions (Monitor Closely)

  • CYP2C9 inhibitors (e.g., fluconazole): may increase plasma levels, requiring observation.
  • Warfarin: letrozole can alter anticoagulant effect; monitor INR closely.

Frequently Asked Questions

Letrozole Zentiva Pharma is used to treat hormone receptor‑positive breast cancer in postmenopausal women. It is prescribed in adjuvant, neoadjuvant, and metastatic settings to lower estrogen levels that can stimulate tumor growth.

Letrozole inhibits the aromatase enzyme, which converts androgens into estrogens. By blocking this conversion, circulating estrogen concentrations fall, reducing the hormonal stimulus that drives the growth of estrogen‑dependent breast cancer cells.

The specific dose of Letrozole Zentiva Pharma is determined by the prescribing clinician based on the patient’s condition, treatment stage, and individual factors. Only a qualified healthcare professional should set the dosing regimen.

Letrozole is contraindicated in pregnancy because it can harm the developing fetus. Its safety during breastfeeding has not been established, and breastfeeding is generally not recommended while on therapy.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Letrozole is a third‑generation aromatase inhibitor with a high potency and a long half‑life, offering consistent estrogen suppression. Compared with anastrozole or exemestane, letrozole often provides slightly greater estrogen reduction, which may translate into marginally improved disease control in some patients.

Letrozole Zentiva Pharma tablets should be stored at ambient temperature, below 25 °C, in the original blister pack or container. Keep them away from moisture, direct sunlight and excessive heat to maintain product stability.

Letrozole is taken orally, usually as a single tablet swallowed whole with water. It can be taken with or without food, but patients should follow the specific instructions provided by their healthcare provider.

Serious risks include severe liver injury, significant bone loss leading to fractures, and rare allergic reactions such as anaphylaxis. Patients should be monitored regularly for liver function, bone health, and any signs of hypersensitivity.

Letrozole is not recommended for premenopausal women, pregnant or nursing individuals, and patients with known hypersensitivity to letrozole or any tablet excipients. Caution is also advised in patients with severe liver impairment or uncontrolled cardiovascular disease.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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