Product image of Letrozole Zydus (Letrozole) supplied by GNH India

Letrozole Zydus

Active Ingredient:
Letrozole
Origin:
EU

Letrozole Zydus (Letrozole)

Letrozole, the active ingredient in Letrozole Zydus, is an aromatase inhibitor presented as an oral tablet for oral use. It is used to treat estrogen receptor‑positive breast cancer in postmenopausal women.
GNH India supplies Letrozole Zydus as a licensed, GDP‑compliant international pharmaceutical supplier serving oncology centres worldwide.

Manufacturer / TM Owner

Zydus France

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Indications & Clinical Uses

Letrozole is an aromatase inhibitor indicated for hormone‑driven breast cancer conditions.

  • Estrogen receptor‑positive breast cancer (postmenopausal): Reduces tumour growth and recurrence risk.
  • Advanced or metastatic breast cancer (postmenopausal): Delays disease progression.
  • Adjuvant therapy after surgery (postmenopausal): Improves disease‑free survival.

How It Works

  • Letrozole selectively inhibits the aromatase enzyme, which converts adrenal and peripheral androgens into estrogens. By blocking this conversion, circulating estrogen levels fall, depriving estrogen‑dependent tumor cells of a growth stimulus and thereby slowing or halting tumor proliferation.

Side Effects

Adverse reactions may occur with Letrozole therapy.

Common Side Effects

  • Hot flashes: Sudden feeling of warmth, often with sweating.
  • Arthralgia: Joint pain or stiffness.
  • Fatigue: Persistent tiredness not relieved by rest.
  • Nausea: Mild to moderate upset stomach.
  • Headache: Pressure or throbbing pain in the head.

Serious or Rare Side Effects

  • Severe liver injury: Jaundice, dark urine, elevated enzymes.
  • Bone fracture: Increased risk of osteoporosis‑related breaks.
  • Deep vein thrombosis or pulmonary embolism: Swelling, pain, or shortness of breath.
  • Anaphylaxis: Rapid onset of rash, swelling, and breathing difficulty.
  • QT interval prolongation: Potential cardiac arrhythmia.

Precautions & Warnings

Patients should be monitored for safety concerns before and during treatment.

  • Bone health monitoring: Assess bone mineral density periodically.
  • Liver function tests: Check hepatic enzymes at baseline and during therapy.
  • Cardiovascular assessment: Evaluate risk factors for thrombosis.
  • Pregnancy avoidance: Contraindicated in pregnancy; ensure effective contraception.
  • Elderly caution: Adjust monitoring for older patients with comorbidities.
  • Store at below 25°C: Keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Letrozole may interact with other medicines, altering efficacy or safety.

Major Interactions (Avoid)

  • Combined estrogen therapy: Negates aromatase inhibition.
  • Strong CYP3A4 inducers (e.g., rifampin, carbamazepine): Reduce plasma levels of letrozole.
  • Antifungal azoles (e.g., ketoconazole): May increase letrozole exposure.

Moderate Interactions (Monitor Closely)

  • CYP2C19 inhibitors (e.g., fluoxetine): Slightly raise letrozole concentrations.
  • Warfarin: May enhance anticoagulant effect; monitor INR.
  • Statins (e.g., simvastatin): Potential for increased muscle toxicity.
  • Glucocorticoids: May affect hormone balance; observe clinical response.

Frequently Asked Questions

Letrozole Zydus is prescribed to treat estrogen receptor‑positive breast cancer in postmenopausal women. It is used as adjuvant therapy after surgery, for advanced or metastatic disease, and to reduce the risk of cancer recurrence by lowering estrogen levels that fuel tumor growth.

Letrozole blocks the aromatase enzyme, which is responsible for converting androgens into estrogens in peripheral tissues. By inhibiting this conversion, circulating estrogen concentrations fall, depriving hormone‑sensitive breast cancer cells of the estrogen signal needed for proliferation.

The specific dose of Letrozole Zydus is determined by the prescribing physician based on the patient’s clinical condition, treatment setting, and individual factors. Healthcare professionals follow approved dosing guidelines and adjust as needed for safety and efficacy.

Letrozole is classified as Pregnancy Category X, meaning it is contraindicated in pregnancy because it can cause fetal harm. It is also not recommended while breastfeeding, as it may pass into breast milk and affect the infant. Effective contraception is required during treatment.

To request Letrozole Zydus, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Letrozole is a third‑generation aromatase inhibitor with a high potency and longer half‑life compared with earlier agents such as anastrozole. Clinical studies show comparable or slightly improved disease‑free survival in certain settings, but choice of agent depends on individual patient factors, tolerability, and physician preference.

Letrozole Zydus tablets should be stored at temperatures below 25 °C (77 °F). Keep them in the original container, protect from moisture, heat, and direct sunlight. Do not store in the bathroom or near a kitchen sink to maintain product stability.

Letrozole Zydus is taken orally, usually once daily, with or without food. The tablet should be swallowed whole with a glass of water. Patients should follow the dosing schedule prescribed by their healthcare provider and not alter the regimen without medical advice.

Serious risks include severe liver injury, osteoporosis‑related fractures, deep vein thrombosis or pulmonary embolism, and rare allergic reactions such as anaphylaxis. Patients should report any signs of jaundice, unexplained bone pain, swelling in the legs, or breathing difficulties to their clinician promptly.

Letrozole Zydus should not be used by pregnant or breastfeeding women, premenopausal women, or individuals with known hypersensitivity to letrozole or any tablet excipients. Caution is also advised for patients with severe liver impairment or uncontrolled cardiovascular disease.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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