Product image of Letrozolo Alter (Letrozole) supplied by GNH India

Letrozolo Alter

Active Ingredient:
Letrozole
Origin:
EU

Letrozolo Alter (Letrozole)

Letrozole, the active ingredient in Letrozolo Alter, is an aromatase inhibitor presented as an oral tablet for oral use. It treats postmenopausal hormone receptor‑positive breast cancer by lowering estrogen production.
GNH India supplies Letrozolo Alter as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Laboratori Alter S.R.L.

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Indications & Clinical Uses

  • Letrozole is used in endocrine therapy for hormone‑dependent breast cancer.
  • Postmenopausal hormone receptor‑positive breast cancer: reduces tumor growth by lowering circulating estrogen levels.
  • Adjuvant therapy: decreases the risk of disease recurrence after surgery.
  • Neoadjuvant therapy: shrinks tumors before surgical removal.

How It Works

  • Letrozole reversibly binds to the aromatase enzyme, inhibiting its activity in peripheral tissues. This blockade prevents the conversion of androgens to estrogens, leading to a marked reduction in systemic estrogen concentrations, which limits the proliferative stimulus on estrogen‑dependent breast cancer cells.

Side Effects

Common Side Effects

  • Hot flashes
  • Joint and muscle pain
  • Fatigue
  • Nausea
  • Headache
  • Increased sweating

Serious or Rare Side Effects

  • Severe liver injury
  • Osteoporotic fractures
  • Pulmonary embolism
  • Deep vein thrombosis
  • Anaphylactic reactions
  • Significant cholesterol elevation

Precautions & Warnings

Letrozolo Alter should be used with caution and under medical supervision.

  • Pregnancy: contraindicated (Category X) – avoid use in pregnant women.
  • Breastfeeding: not recommended – discontinue if nursing.
  • Liver function: monitor in patients with hepatic impairment.
  • Bone health: assess risk of osteoporosis and consider calcium/vitamin D supplementation.
  • Drug interactions: review concomitant medications for potential interactions.
  • Store at ambient temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Letrozolo Alter may interact with several medicines.

Major Interactions (Avoid)

  • Estrogen replacement therapy: may diminish letrozole efficacy.
  • Tamoxifen: antagonistic effect on estrogen pathways.
  • Strong CYP2C19 inhibitors: can increase letrozole plasma concentrations.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inducers (e.g., rifampin): may lower letrozole levels.
  • Anticoagulants (e.g., warfarin): monitor INR and bleeding risk.
  • Diuretics: may affect electrolyte balance and renal function.

Frequently Asked Questions

Letrozolo Alter contains letrozole, an aromatase inhibitor indicated for the treatment of postmenopausal women with hormone receptor‑positive breast cancer, either as adjuvant, neoadjuvant, or metastatic therapy.

Letrozole blocks the aromatase enzyme, which converts androgens into estrogens. By inhibiting this conversion, estrogen levels fall, reducing the growth stimulus for estrogen‑dependent breast cancer cells.

The specific dose and regimen are determined by the prescribing physician based on the patient’s clinical condition, treatment stage, and individual factors. No fixed dose is provided here.

Letrozolo Alter is classified as Pregnancy Category X, meaning it is contraindicated in pregnancy. It is also not recommended for breastfeeding women because it may pass into breast milk and affect the infant.

Submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and necessary import documentation.

Letrozole belongs to the aromatase inhibitor class, which directly lowers estrogen production, unlike selective estrogen receptor modulators such as tamoxifen that block estrogen receptors. Aromatase inhibitors are generally preferred for postmenopausal patients due to higher efficacy in this population.

Store Letrozolo Alter at ambient temperature, below 25 °C, in the original packaging. Keep it away from moisture, direct sunlight, and excessive heat to maintain product stability.

Letrozolo Alter is taken orally, usually as a tablet swallowed with water. The exact timing (e.g., with or without food) should follow the prescribing physician’s instructions.

Serious risks include severe liver injury, osteoporotic fractures, and thromboembolic events such as deep‑vein thrombosis or pulmonary embolism. Patients should be monitored regularly for signs of these conditions.

Letrozolo Alter should not be used by pregnant women, individuals with known hypersensitivity to letrozole, or patients with severe hepatic impairment without careful monitoring. It is also contraindicated in premenopausal women unless ovarian function suppression is confirmed.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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