Product image of Letrozolo Eg (Letrozole) supplied by GNH India

Letrozolo Eg

Active Ingredient:
Letrozole
Origin:
EU

Letrozolo Eg (Letrozole)

Letrozole, the active ingredient in Letrozolo Eg, is a aromatase inhibitor presented as a oral tablet for oral use. It treats postmenopausal hormone receptor‑positive breast cancer and is used as adjuvant therapy in early‑stage disease.

GNH India supplies Letrozolo Eg as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres and pharmacies worldwide.

Manufacturer / TM Owner

Eg S.P.A.

1
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Indications & Clinical Uses

  • Letrozolo Eg is an aromatase inhibitor used in breast‑cancer treatment pathways.
  • Postmenopausal hormone‑receptor‑positive breast cancer: reduces tumor growth and recurrence.
  • Adjuvant treatment of early‑stage breast cancer: lowers risk of disease progression.
  • Estrogen‑dependent breast cancer: helps prevent recurrence after surgery or radiation.

How It Works

  • Letrozole reversibly binds to the aromatase enzyme, blocking the conversion of androgens to estrogens in peripheral tissues. By lowering circulating estrogen levels, it deprives estrogen‑dependent tumor cells of a growth stimulus, thereby inhibiting proliferation of hormone‑sensitive breast cancer cells.

Side Effects

Letrozolo Eg may cause a range of adverse reactions. Patients should be monitored for any new symptoms.

Common Side Effects

  • Hot flashes: transient episodes of increased warmth.
  • Arthralgia: joint pain or stiffness.
  • Fatigue: generalized tiredness.
  • Nausea: mild to moderate upset stomach.
  • Headache: occasional mild pain.
  • Osteoporosis: reduced bone mineral density over long‑term use.

Serious or Rare Side Effects

  • Venous thromboembolism: blood clots in deep veins.
  • Severe liver injury: marked elevation of hepatic enzymes.
  • Interstitial lung disease: inflammation of lung tissue.
  • Cardiovascular events: increased risk of heart attack or stroke.

Precautions & Warnings

  • Before initiating Letrozolo Eg, clinicians should evaluate patient history and comorbidities.
  • Assess bone health: consider baseline densitometry and calcium/vitamin D supplementation.
  • Monitor liver function: periodic testing for hepatic enzymes.
  • Evaluate cardiovascular risk: screen for hypertension, hyperlipidaemia.
  • Avoid use in pregnancy: Letrozole is contraindicated (Category X).
  • Store at ambient temperature: keep below 25°C in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Letrozolo Eg can interact with several medicines that affect its metabolism or hormone levels.

Major Interactions (Avoid)

  • Strong CYP2A6 inhibitors (e.g., fluvoxamine): may increase Letrozole exposure.
  • Estrogen‑containing hormone therapy: antagonises therapeutic effect.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inducers (e.g., rifampicin): may reduce Letrozole plasma concentrations.
  • Anticoagulants (e.g., warfarin): may require INR monitoring.
  • Tamoxifen: concurrent use may diminish efficacy of both agents.

Frequently Asked Questions

Letrozolo Eg contains letrozole, an aromatase inhibitor indicated for the treatment of postmenopausal hormone‑receptor‑positive breast cancer and as adjuvant therapy in early‑stage disease to reduce the risk of recurrence.

Letrozole blocks the aromatase enzyme, preventing the conversion of androgens into estrogens. Lower estrogen levels deprive estrogen‑dependent breast cancer cells of a growth signal, thereby inhibiting tumor proliferation.

The dose of letrozole is determined by the prescribing clinician based on the patient’s clinical condition, renal and hepatic function, and treatment guidelines. Patients should follow the exact regimen prescribed by their healthcare professional.

Letrozole is classified as Pregnancy Category X, meaning it is contraindicated in pregnancy due to potential fetal harm. It is also not recommended during breastfeeding because it may pass into milk and affect the infant.

To request Letrozolo Eg, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Letrozolo Eg (letrozole) is an oral aromatase inhibitor, whereas alternatives such as tamoxifen are selective estrogen receptor modulators. Letrozole generally provides stronger estrogen suppression and is often preferred for postmenopausal patients, while tamoxifen may be used in premenopausal women.

Letrozolo Eg should be stored at ambient temperature, below 25 °C, in its original packaging. Keep the product away from moisture, direct sunlight and heat sources to maintain stability.

Letrozolo Eg is taken orally, usually as a tablet swallowed whole with water. It is typically taken once daily, with or without food, as directed by the prescribing physician.

Serious risks include venous thromboembolism, severe liver injury, interstitial lung disease, and cardiovascular events such as heart attack or stroke. Patients should be monitored regularly for signs of these conditions.

Letrozolo Eg should not be used by pregnant women, individuals with known hypersensitivity to letrozole or other aromatase inhibitors, and patients with severe liver impairment without specialist supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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