Product image of Letrozolo Sun (Letrozole) supplied by GNH India

Letrozolo Sun

Active Ingredient:
Letrozole
Origin:
EU

Letrozolo Sun (Letrozole)

Letrozole, the active ingredient in Letrozolo Sun, is an aromatase inhibitor presented as an oral tablet for oral use. It is used to treat hormone receptor‑positive breast cancer in postmenopausal women.
GNH India supplies Letrozolo Sun as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Sun Pharmaceutical Industries Europe B.V.

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Indications & Clinical Uses

Letrozole is an aromatase inhibitor used in the management of breast cancer and related endocrine pathways.

  • Hormone receptor‑positive breast cancer (postmenopausal): Reduces risk of disease recurrence.
  • Advanced breast cancer (postmenopausal): Delays progression of tumor growth.
  • Metastatic breast cancer (postmenopausal): Improves overall survival outcomes.

How It Works

  • Letrozole reversibly binds to the aromatase enzyme, inhibiting its activity and thereby decreasing the peripheral conversion of androgens to estrogens. This reduction in estrogen levels limits the hormonal stimulation of estrogen‑dependent breast cancer cells, slowing tumor growth and proliferation.

Side Effects

Letrozole may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Hot flashes: Sudden feeling of warmth and sweating.
  • Joint pain: Discomfort or aching in joints.
  • Fatigue: Persistent tiredness not relieved by rest.
  • Nausea: Feeling of sickness in the stomach.

Serious or Rare Side Effects

  • Severe liver injury: Marked elevation of liver enzymes or hepatitis.
  • Bone fractures: Increased risk of osteoporosis‑related fractures.
  • Allergic reactions: Rash, swelling, or anaphylaxis.

Precautions & Warnings

Before initiating Letrozolo Sun, clinicians should consider several safety measures.

  • Bone health monitoring: Assess bone mineral density regularly.
  • Liver function testing: Check baseline and periodic liver enzymes.
  • Cardiovascular risk assessment: Evaluate history of thromboembolic events.
  • Drug hypersensitivity review: Avoid use in patients with known letrozole allergy.
  • Concomitant medication review: Adjust doses of drugs metabolized by CYP3A4.
  • Store at ambient temperature: Keep in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Letrozolo Sun can interact with other medicines, requiring careful management.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole): May increase letrozole plasma levels.
  • Estrogen replacement therapy: Counteracts aromatase inhibition effect.
  • Tamoxifen: Reduces therapeutic efficacy when combined.

Moderate Interactions (Monitor Closely)

  • Moderate CYP3A4 inhibitors (e.g., erythromycin): May modestly raise letrozole concentrations.
  • CYP2C8 inhibitors (e.g., gemfibrozil): Can affect metabolism.
  • Warfarin: May enhance anticoagulant effect, requiring INR monitoring.

Frequently Asked Questions

Letrozolo Sun contains letrozole, an aromatase inhibitor indicated for the treatment of hormone receptor‑positive breast cancer in postmenopausal women. It is employed in adjuvant, advanced and metastatic settings to reduce estrogen‑driven tumor growth.

Letrozole blocks the aromatase enzyme, which converts androgens into estrogens. By inhibiting this conversion, systemic estrogen levels fall, depriving estrogen‑dependent breast cancer cells of the hormonal stimulus needed for proliferation.

The specific dose of Letrozolo Sun is determined by the prescribing clinician based on the patient’s clinical condition, treatment stage and individual factors. Healthcare professionals follow established guidelines to select the appropriate regimen.

Letrozole is contraindicated in pregnancy because it can affect fetal development. It is also not recommended for breastfeeding mothers, as it may pass into breast milk. Women of child‑bearing potential should use effective contraception during treatment.

To request Letrozolo Sun, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Letrozole, as an aromatase inhibitor, reduces estrogen production, whereas drugs like tamoxifen act as selective estrogen receptor modulators. In postmenopausal patients, aromatase inhibitors such as letrozole generally provide superior disease‑free survival compared with tamoxifen in many clinical trials.

Letrozolo Sun should be stored at ambient temperature, below 25 °C, in its original container. Protect the product from moisture, direct sunlight and extreme temperatures to maintain potency throughout its shelf life.

Letrozolo Sun is taken orally, usually as a single tablet once daily, with or without food. Patients should follow the dosing schedule prescribed by their healthcare provider and swallow the tablet whole with water.

Serious risks include severe liver injury, osteoporosis‑related fractures, and rare but potentially life‑threatening allergic reactions. Patients should be monitored regularly for liver function, bone health and any signs of hypersensitivity.

Letrozolo Sun is not recommended for premenopausal women, patients with known hypersensitivity to letrozole, those with active liver disease, or individuals who are pregnant or breastfeeding. Clinicians must evaluate each patient’s medical history before initiating therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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