Product image of Letrozolo Zentiva (Letrozole) supplied by GNH India

Letrozolo Zentiva

Active Ingredient:
Letrozole
Origin:
EU

Letrozolo Zentiva (Letrozole)

Letrozole, the active ingredient in Letrozolo Zentiva, is an aromatase inhibitor presented as an oral tablet for oral use. It is employed in the endocrine treatment of postmenopausal women with hormone receptor‑positive breast cancer, reducing estrogen‑driven tumor growth.

GNH India supplies Letrozolo Zentiva as a licensed, GDP‑compliant international pharmaceutical supplier serving oncology centres, hospitals and pharmacies worldwide, with a focus on reliable quality, regulatory compliance and timely delivery to meet the needs of cancer care providers across global markets through established distribution networks.

Manufacturer / TM Owner

Zentiva Italia S.R.L.

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Indications & Clinical Uses

  • Letrozole is used as an endocrine therapy targeting estrogen‑dependent breast cancer pathways.
  • Postmenopausal hormone receptor‑positive breast cancer: reduces risk of disease recurrence and progression.
  • Adjuvant therapy for early‑stage disease: improves disease‑free survival after surgery.
  • Metastatic breast cancer: provides disease control in patients with advanced hormone‑sensitive tumors.

How It Works

  • Letrozole reversibly binds to the aromatase enzyme, a cytochrome P450 isoform responsible for converting androstenedione and testosterone into estrone and estradiol. By inhibiting this conversion, systemic estrogen levels fall markedly, depriving estrogen‑dependent tumor cells of a growth stimulus and thereby slowing or halting tumor proliferation. The inhibition is dose‑dependent and persists for several days after the last dose, allowing once‑daily oral administration.

Side Effects

Letrozole may cause a range of adverse reactions, which are generally classified by frequency and severity.

Common Side Effects

  • Hot flashes
  • Joint and muscle pain
  • Fatigue
  • Nausea
  • Headache
  • Diarrhea

Serious or Rare Side Effects

  • Osteoporosis or bone fracture
  • Severe liver injury (hepatitis, hepatic failure)
  • Pulmonary embolism or deep‑vein thrombosis
  • Severe allergic reactions (anaphylaxis, Stevens‑Johnson syndrome)
  • Cardiovascular events (myocardial infarction, stroke)

Precautions & Warnings

  • Before initiating therapy, clinicians should assess individual risk factors and monitor patients regularly.
  • Monitor bone health: assess calcium, vitamin D status and consider bisphosphonates.
  • Assess liver function: perform baseline and periodic liver enzyme tests.
  • Evaluate cardiovascular risk: monitor lipid profile and blood pressure.
  • Avoid use in premenopausal women: drug is ineffective and may cause ovarian stimulation.
  • Counsel on pregnancy risk: contraindicated in pregnancy; effective contraception required.
  • Store at ambient temperature: keep below 25 °C, protect from moisture and light in the original container.

Avoid Interactions

Letrozole can interact with other medicines, altering its efficacy or safety.

Major Interactions (Avoid)

  • Concomitant estrogen replacement therapy: may negate therapeutic effect.
  • Strong CYP3A4 inducers (e.g., rifampin, carbamazepine): reduce plasma levels and efficacy.

Moderate Interactions (Monitor Closely)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may increase exposure and toxicity.
  • Warfarin: potential increase in INR, monitor coagulation parameters.
  • Statins (e.g., simvastatin): may require dose adjustment due to shared metabolic pathways.

Frequently Asked Questions

Letrozolo Zentiva contains letrozole, an aromatase inhibitor indicated for the treatment of postmenopausal women with hormone receptor‑positive breast cancer, including adjuvant therapy for early‑stage disease and management of metastatic disease.

Letrozole blocks the aromatase enzyme, preventing the conversion of androgens to estrogen. This lowers circulating estrogen levels, depriving estrogen‑dependent breast cancer cells of a key growth signal and thereby inhibiting tumor proliferation.

The prescribed dose of Letrozolo Zentiva is determined by the treating physician based on the patient’s clinical condition, treatment setting and individual response. Typically, the medication is taken once daily, but exact dosing must follow the prescriber’s instructions.

Letrozole is contraindicated in pregnancy because it can harm the developing fetus. Women of childbearing potential should use effective contraception during treatment. Safety during breastfeeding has not been established, and breastfeeding is generally not recommended while on letrozole.

To request Letrozolo Zentiva, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Letrozolo Zentiva (letrozole) is a third‑generation aromatase inhibitor with a long half‑life, allowing once‑daily dosing. Compared with anastrozole or exemestane, letrozole often provides slightly greater estrogen suppression, which may translate into marginally higher efficacy in certain settings, though safety profiles are broadly similar.

Store Letrozolo Zentiva tablets at ambient temperature, preferably below 25 °C, in the original blister pack. Protect from moisture, heat and direct sunlight. Keep the product out of reach of children and do not use after the expiry date.

Letrozolo Zentiva is taken orally as a tablet. Swallow the tablet whole with a glass of water, preferably at the same time each day. It may be taken with or without food, but consistency helps maintain stable drug levels.

Serious risks include significant bone loss leading to osteoporosis or fractures, severe liver injury, and rare thromboembolic events such as pulmonary embolism. Patients should be monitored regularly for bone density, liver function and signs of clotting disorders.

Letrozolo Zentiva should not be used in premenopausal women, pregnant or breastfeeding individuals, and patients with known hypersensitivity to letrozole or any tablet excipients. Caution is also advised for patients with severe liver impairment or uncontrolled cardiovascular disease.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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