Product image of Leucorin (Leucovorin Calcium IP) 50mg/5ml Vials supplied by GNH India

Leucorin

Active Ingredient:
Leucovorin Calcium IP
Form:
Vials
Brand:
Leucorin
Origin:
India

Leucorin (Leucovorin Calcium IP Vials) 50mg/5ml

Leucovorin Calcium IP is a folate derivative used to reduce toxic effects of folate antagonists like methotrexate. This 50mg/5ml vial form supports supportive care in chemotherapy regimens. Store at 2–8°C to maintain potency. Ideal for clinical settings requiring precise folinic acid rescue.

Strength

50mg/5ml

Pack Size

1s

Storage

2-8°

Manufacturer / TM Owner

Samarth Life Sciences Pvt Ltd

1
Pack/s
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Indications & Clinical Uses

  • Leucovorin Calcium IP is used to counteract the effects of folic acid antagonists such as methotrexate in chemotherapy. It also supports high-dose methotrexate therapy by rescuing normal cells from toxicity. This medication is commonly used in cancer treatment protocols where folate rescue is necessary. It may also be used in cases of folate deficiency or to enhance the effects of 5-fluorouracil in certain regimens.

Side Effects

  • Leucovorin Calcium IP works by providing the body with active folate, which helps restore normal cell function during or after chemotherapy. It supports DNA synthesis and repair in healthy cells, reducing the risk of severe side effects from folate antagonists. Patients may notice improved tolerance to chemotherapy when this medication is used as directed.

Precautions & Warnings

  • Leucovorin Calcium IP should be handled with care and stored at 2–8°C to maintain its effectiveness. It is intended for use under medical supervision, and patients should follow their healthcare provider’s instructions closely. Avoid exposure to extreme temperatures or direct sunlight. Always check the vial for clarity and particles before administration.

Avoid Interactions

  • Leucovorin Calcium IP may interact with certain medications, including other folate antagonists and some antibiotics. Combining it with fluorouracil can enhance its effects, while certain anticonvulsants may reduce its efficacy. Alcohol and other substances that affect folate metabolism should be used cautiously. Always inform your healthcare provider about all medications you are taking.

Frequently Asked Questions

It is primarily used to reduce toxic effects of folate antagonists like methotrexate in chemotherapy.

Store vials at 2–8°C and protect from light to maintain potency.

Yes, it is often used alongside drugs like 5-fluorouracil to enhance efficacy and reduce side effects.

It helps restore normal cell function and supports DNA synthesis during chemotherapy.

It should only be used under medical supervision, as individual responses may vary.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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