Leucovorin (Calcium Folinate)

Calcium Folinate supplies reduced folate that bypasses the block of dihydrofolate reductase, allowing normal cells to resume DNA synthesis and repair while also enhancing the activation of fluorouracil metabolites, thereby supporting both rescue and therapeutic functions.

The dose of Leucovorin is individualized and determined by the prescribing clinician based on the specific chemotherapy regimen, patient renal function, and therapeutic goals. No standard dosing is provided here.

Safety data for Leucovorin in pregnancy are limited, and it should only be used if the potential benefit justifies the potential risk to the fetus. Breastfeeding mothers should discuss possible excretion in milk with their healthcare provider.

To order Leucovorin, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed), and import documentation.

Leucovorin (calcium folinate) is the most widely used reduced‑folate form for methotrexate rescue and fluorouracil adjunct therapy. Compared with oral folic acid, it provides a more direct and rapid replenishment of intracellular folate pools, which is essential for intravenous chemotherapy protocols.

Leucovorin injectable solution should be stored at 2‑8 °C, protected from light, and must not be frozen or shaken. Before use, inspect the vial for particulate matter and ensure the solution is clear.

Leucovorin is administered by intramuscular or intravenous injection, typically as a sterile solution. The route, rate, and timing are determined by the treating physician according to the chemotherapy protocol and patient condition.

Serious risks include severe allergic reactions (anaphylaxis), acute renal impairment, significant electrolyte disturbances, and hemolytic anemia in patients with glucose‑6‑phosphate dehydrogenase deficiency. Prompt medical attention is required if any of these occur.

Leucovorin is contraindicated in patients with known hypersensitivity to calcium folinate or any component of the formulation. Caution is advised for individuals with severe renal or hepatic impairment, and it should be avoided in pregnant women unless clearly indicated.