Product image of Leukeran (Chlorambucil) supplied by GNH India

Leukeran

Active Ingredient:
Chlorambucil
Origin:
EU

Leukeran (Chlorambucil)

Chlorambucil, the active ingredient in Leukeran, is an alkylating agent presented as an oral formulation for oral use. It is employed in the treatment of chronic lymphocytic leukemia, Hodgkin's lymphoma and other lymphoid malignancies in adult patients.

GNH India supplies Leukeran as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres and pharmacies worldwide.

Manufacturer / TM Owner

Aspen Pharma Trading Limited

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Indications & Clinical Uses

Leukeran (chlorambucil) is used in hematologic cancers that involve malignant lymphoid cells.

  • Chronic lymphocytic leukemia: helps control disease progression and improve survival.
  • Hodgkin's lymphoma: used as part of combination therapy to achieve remission.
  • Other lymphoid malignancies: provides therapeutic benefit in selected non‑Hodgkin lymphomas and related disorders.

How It Works

  • Chlorambucil is an alkylating agent that forms covalent bonds with DNA bases, creating cross‑links that prevent DNA strand separation. This interference blocks DNA replication and transcription, leading to apoptosis of rapidly dividing malignant lymphoid cells while sparing most normal tissues.

Side Effects

Leukeran may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Nausea and vomiting: gastrointestinal upset occurring shortly after dosing.
  • Bone marrow suppression: anemia, leukopenia, and thrombocytopenia due to reduced blood cell production.
  • Alopecia: hair loss that is usually reversible after treatment.
  • Fatigue: general tiredness and reduced stamina.
  • Mild rash or itching: skin irritation at the site of drug exposure.

Serious or Rare Side Effects

  • Secondary malignancies: increased risk of developing new cancers after prolonged use.
  • Severe myelosuppression: life‑threatening infections or bleeding due to profound blood count drops.
  • Pulmonary fibrosis: scarring of lung tissue causing breathing difficulties.
  • Hepatic toxicity: elevated liver enzymes or liver injury.
  • Severe allergic reactions: anaphylaxis or serum sickness‑like symptoms.
  • Renal impairment: reduced kidney function in susceptible individuals.

Precautions & Warnings

When prescribing or handling Leukeran, several safety measures are recommended.

  • Monitor blood counts: perform regular complete blood count tests to detect myelosuppression early.
  • Assess organ function: evaluate liver and kidney function before and during therapy.
  • Avoid use in active infections: postpone treatment if the patient has uncontrolled infections.
  • Pregnancy and lactation: contraindicated unless benefits outweigh risks; discuss alternatives with the prescriber.
  • Drug interactions: review concomitant medications for potential additive myelosuppressive effects.
  • Store at ambient temperature below 25°C: keep in the original container, protect from moisture.

Avoid Interactions

Chlorambucil can interact with several medicines, altering its efficacy or safety.

Major Interactions (Avoid)

  • Live vaccines: may cause severe infection due to immunosuppression.
  • Other alkylating agents: increase risk of severe bone marrow toxicity.
  • Warfarin: potentiates anticoagulant effect, raising bleeding risk.
  • CYP2D6 inhibitors: may raise chlorambucil plasma levels.
  • High‑dose folic acid: can reduce drug effectiveness.

Moderate Interactions (Monitor Closely)

  • NSAIDs: may increase gastrointestinal irritation.
  • Allopurinol: can enhance chlorambucil toxicity.
  • ACE inhibitors: monitor renal function and blood pressure.
  • Antifungal azoles: may affect drug metabolism.
  • Immunosuppressants: require careful blood count monitoring.

Frequently Asked Questions

Leukeran, whose active ingredient is chlorambucil, is used as an oral chemotherapy for chronic lymphocytic leukemia, Hodgkin's lymphoma and other selected lymphoid malignancies. It works by targeting rapidly dividing cancer cells to help control disease progression.

Chlorambucil belongs to the alkylating agent class. It attaches alkyl groups to DNA bases, creating cross‑links that block DNA replication and transcription. This damage triggers apoptosis in malignant lymphoid cells while sparing most normal tissues.

The exact dose of chlorambucil is individualized. A qualified prescriber determines the appropriate strength, frequency and duration based on the patient’s diagnosis, disease stage, organ function and overall health. Patients should follow the prescribing information provided by their healthcare professional.

Data on chlorambucil use during pregnancy and lactation are limited, and the drug may pose risks to the fetus or infant. It is generally contraindicated unless the potential benefit justifies the risk. Women who are pregnant, planning pregnancy, or breastfeeding should discuss alternatives with their physician.

To request Leukeran, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide. After verification of trade or institutional credentials, the GNH team will provide pricing, availability, shipping details (including any cold‑chain requirements) and assist with import documentation.

Leukeran (chlorambucil) is an oral alkylating agent, offering convenience compared with intravenous regimens. While effective for certain lymphoid cancers, it may have a slower onset of action than newer targeted therapies. Its side‑effect profile includes bone‑marrow suppression, which is similar to other alkylators, but it lacks some of the cardiac or neuropathic toxicities seen with alternative classes.

Leukeran tablets should be stored at ambient temperature below 25 °C, in the original packaging, and protected from moisture and direct sunlight. Keep the product out of reach of children and do not use if the packaging is damaged or the tablets appear discolored.

Leukeran is taken orally, usually with a glass of water. The tablet should be swallowed whole and not crushed or chewed unless directed by a healthcare professional. Dosing times (e.g., with or without food) are determined by the prescriber based on the individual treatment plan.

The most serious risks include severe bone‑marrow suppression leading to infections, anemia or bleeding; secondary malignancies; pulmonary fibrosis; and significant liver or kidney toxicity. Patients should promptly report fever, unusual bruising, persistent cough, shortness of breath, or jaundice to their physician.

Leukeran is contraindicated in patients with known hypersensitivity to chlorambucil or other alkylating agents, those with uncontrolled active infections, severe bone‑marrow failure, or pregnant women unless the benefit outweighs the risk. Individuals with significant hepatic or renal impairment should be evaluated carefully before use.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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