Product image of Leukeran (Chlorambucil) supplied by GNH India

Leukeran

Active Ingredient:
Chlorambucil
Origin:
EU

Leukeran (Chlorambucil)

Chlorambucil, the active ingredient in Leukeran, is an alkylating agent presented as a tablet for oral use. It is employed in the treatment of chronic lymphocytic leukemia, Hodgkin's lymphoma, non‑Hodgkin's lymphoma and other lymphoid malignancies.\n\nGNH India supplies Leukeran as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres, pharmacies and clinics worldwide. Our global network ensures reliable delivery, regulatory compliance and quality assurance for oncology therapeutics.

Manufacturer / TM Owner

Aspen Pharma Trading Limited

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

  • Leukeran (chlorambucil) is used in the management of lymphoid malignancies, targeting rapidly proliferating cancer cells.\n\nChronic lymphocytic leukemia: induces disease control and can achieve remission.\nHodgkin's lymphoma: contributes to disease remission when used as part of combination therapy.\nNon‑Hodgkin's lymphoma: provides therapeutic benefit and disease stabilization.\nOther lymphoid malignancies: offers clinical benefit as part of treatment regimens.

How It Works

  • Chlorambucil is an alkylating nitrogen‑mustard agent that covalently binds to DNA bases, forming intra‑ and interstrand cross‑links. These cross‑links impede DNA replication and transcription, leading to cell cycle arrest and apoptosis of rapidly dividing lymphoid cells. The drug is metabolized in the liver to active metabolites that retain alkylating activity, and its non‑selective action also affects normal proliferating cells, contributing to its toxicity profile.

Side Effects

  • Chlorambucil may cause a range of adverse reactions, varying from mild to severe.\n\nCommon Side Effects:\n- Nausea: mild to moderate gastrointestinal upset.\n- Fatigue: persistent tiredness.\n- Myelosuppression: decreased blood counts such as neutropenia and anemia.\n- Alopecia: hair thinning or loss.\n\nSerious or Rare Side Effects:\n- Severe neutropenia: increased risk of infection.\n- Secondary malignancies: possible development of other cancers.\n- Pulmonary fibrosis: rare lung scarring.

Precautions & Warnings

  • Before prescribing Leukeran, clinicians should consider several precautionary measures to minimize risks.\n\n- Baseline blood counts: obtain a complete blood count before initiating therapy.\n- Renal and hepatic function: assess kidney and liver status as impairment may affect drug clearance.\n- Pregnancy: contraindicated in pregnancy due to teratogenic risk; avoid use in pregnant women.\n- Concomitant immunosuppressants: monitor for additive bone marrow suppression.\n- Infection risk: advise patients to report signs of infection promptly.\n- Store at ambient temperature: keep tablets below 25°C in original packaging, protect from moisture.

Avoid Interactions

  • Chlorambucil interacts with several medicines; awareness of these interactions helps prevent adverse outcomes.\n\nMajor Interactions (Avoid):\n- Live vaccines: increased risk of infection; avoid concurrent use.\n- Strong CYP450 inducers (e.g., rifampin): may reduce chlorambucil efficacy.\n- Anticoagulants (e.g., warfarin): heightened bleeding risk due to myelosuppression.\n\nModerate Interactions (Monitor Closely):\n- Other myelosuppressive agents: additive bone marrow toxicity.\n- Allopurinol: may increase chlorambucil plasma levels.\n- NSAIDs: potential for enhanced gastrointestinal irritation.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Related Products

Other formulations containing Chlorambucil

A

A
A

A
A

A
A

A

Browse all products →

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Regulatory recognitions

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.

SGS GSDP Certification

GSDP Compliant from SGS

URS ISO 9001

URS ISO 9001 Certification

FDA Maharashtra

Licensed by FDA Maharashtra

IEC License DGFT

IEC License issued by DGFT