Product image of Leukeran (Chlorambucil) supplied by GNH India

Leukeran

Active Ingredient:
Chlorambucil
Origin:
EU

Leukeran (Chlorambucil)

Chlorambucil, the active ingredient in Leukeran, is an alkylating agent presented as a tablet for oral use. It treats chronic lymphocytic leukemia, Hodgkin's lymphoma, non‑Hodgkin lymphoma and other lymphoid malignancies in adult patients.
GNH India supplies Leukeran as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres and pharmacies worldwide.

Manufacturer / TM Owner

Aspen Pharma Trading Limited

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Indications & Clinical Uses

Leukeran is an oral alkylating antineoplastic indicated for several lymphoid cancers.

  • Chronic lymphocytic leukemia: helps control disease progression and prolongs survival.
  • Hodgkin's lymphoma: contributes to remission when used as part of combination chemotherapy.
  • Non‑Hodgkin lymphoma: reduces tumor burden and extends progression‑free intervals.

How It Works

  • Chlorambucil alkylates DNA by forming covalent cross‑links between DNA strands, which interferes with DNA replication and transcription. This disruption triggers cell cycle arrest and apoptosis, preferentially affecting rapidly dividing malignant lymphoid cells while sparing most normal tissues.

Side Effects

Leukeran may cause a range of adverse reactions that vary in frequency and severity.

Common Side Effects

  • Nausea and vomiting: mild to moderate gastrointestinal upset.
  • Bone marrow suppression: decreased white blood cells, red cells, or platelets.
  • Alopecia: temporary hair loss.
  • Fatigue: generalized tiredness.
  • Diarrhea: mild to moderate loose stools.

Serious or Rare Side Effects

  • Severe myelosuppression: risk of life‑threatening infections or bleeding.
  • Secondary malignancies: potential development of new cancers.
  • Pulmonary fibrosis: progressive lung scarring.
  • Severe allergic reactions: rash, swelling, or anaphylaxis.
  • Hepatic toxicity: elevated liver enzymes or liver injury.

Precautions & Warnings

Before initiating therapy, clinicians should evaluate patient‑specific factors and monitor for toxicity.

  • Monitor blood counts: perform regular complete blood count testing.
  • Assess renal function: adjust use in patients with impaired kidney function.
  • Evaluate hepatic function: check liver enzymes periodically.
  • Avoid use in pregnancy: drug is contraindicated due to fetal risk.
  • Use effective contraception: both male and female patients of reproductive potential should employ reliable birth control.
  • Store at below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Chlorambucil can interact with other medicines, altering efficacy or safety.

Major Interactions (Avoid)

  • Live attenuated vaccines: may cause uncontrolled infection.
  • Other myelotoxic agents (e.g., cyclophosphamide, azathioprine): increase risk of severe bone‑marrow suppression.
  • High‑dose radiation therapy: amplifies tissue toxicity.

Moderate Interactions (Monitor Closely)

  • NSAIDs: may increase gastrointestinal irritation.
  • Anticoagulants (warfarin, DOACs): heightened bleeding tendency.
  • Allopurinol: potential enhancement of myelosuppression.

Frequently Asked Questions

Leukeran is the brand name for chlorambucil tablets, an oral alkylating chemotherapy used to treat chronic lymphocytic leukemia, Hodgkin's lymphoma, non‑Hodgkin lymphoma and other lymphoid malignancies in adult patients.

Chlorambucil alkylates DNA, creating cross‑links that block DNA replication and transcription. This damage triggers cell‑cycle arrest and apoptosis, especially in rapidly dividing cancer cells of the lymphoid system.

The prescribed dose of Leukeran is individualized by the treating physician based on the specific cancer type, disease stage, patient weight, renal and hepatic function, and tolerance to therapy. No fixed regimen is provided here.

Leukeran is classified as Pregnancy Category D, indicating evidence of fetal risk. It should not be used during pregnancy, and breastfeeding is not recommended because the drug can be excreted in milk and may harm the infant.

To request Leukeran, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Leukeran (chlorambucil) is an oral alkylating agent with a relatively long half‑life, offering convenient dosing compared with intravenous agents like cyclophosphamide. While both share a similar mechanism of DNA cross‑linking, chlorambucil is often chosen for chronic lymphocytic leukemia because of its oral route and established efficacy profile.

Leukeran tablets should be stored at temperatures below 25 °C, in the original container, protected from moisture and direct sunlight. Keep out of reach of children and do not use if the packaging is damaged.

Leukeran is taken orally as a tablet, usually with a full glass of water. It may be taken with or without food, but patients should follow the prescribing physician’s instructions regarding timing and any required fasting.

The most serious risks include severe myelosuppression leading to infection or bleeding, secondary malignancies, pulmonary fibrosis, and significant hepatic toxicity. Patients should be monitored closely for signs of infection, unexplained bruising, respiratory symptoms, or liver dysfunction.

Leukeran is contraindicated in pregnant women, patients with known hypersensitivity to chlorambucil or other alkylating agents, and those with severe bone‑marrow suppression. Caution is also advised for individuals with significant renal or hepatic impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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