Product image of Levalox (Levofloxacin) supplied by GNH India

Levalox

Active Ingredient:
Levofloxacin
Origin:
EU

Levalox (Levofloxacin)

Levofloxacin, the active ingredient in Levalox, is a fluoroquinolone antibiotic presented as an oral tablet for systemic use. It treats a range of bacterial infections in adults and children as prescribed.

GNH India supplies Levalox as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Krka-Farma D.O.O.

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Indications & Clinical Uses

Levalox, a fluoroquinolone antibacterial, is used to treat infections caused by susceptible bacteria.

  • Community‑acquired pneumonia: effective treatment of bacterial pneumonia caused by susceptible organisms.
  • Acute bacterial sinusitis: eradicates the causative pathogens and relieves sinus inflammation.
  • Acute exacerbations of chronic bronchitis: reduces bacterial load and improves respiratory symptoms.
  • Urinary tract infections: clears infection of the urinary tract caused by sensitive bacteria.
  • Skin and soft tissue infections: combats bacterial skin infections and promotes healing.

How It Works

  • Levofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, enzymes essential for DNA replication, transcription, and repair. By binding to these enzymes, it prevents the unwinding and resealing of DNA strands, leading to halted bacterial cell division and ultimately bacterial cell death.

Side Effects

Levalox may cause a range of adverse reactions, from mild to serious.

Common Side Effects

  • Nausea: mild to moderate upset stomach.
  • Diarrhea: loose stools, sometimes watery.
  • Headache: transient cranial discomfort.
  • Dizziness: sensation of light‑headedness.
  • Abdominal pain: cramping or discomfort.
  • Rash: mild skin irritation or redness.

Serious or Rare Side Effects

  • Tendon rupture: sudden pain and loss of function, especially in the Achilles tendon.
  • QT interval prolongation: potential cardiac arrhythmias.
  • Severe allergic reactions: anaphylaxis, swelling, or hives.
  • Clostridioides difficile‑associated diarrhea: severe colitis requiring medical attention.
  • Hepatic dysfunction: elevated liver enzymes or jaundice.
  • Peripheral neuropathy: tingling or numbness in extremities.

Precautions & Warnings

Before prescribing Levalox, consider the following safety measures.

  • Renal function assessment: adjust dose in patients with impaired kidney function.
  • Tendon health monitoring: advise patients to report tendon pain or swelling.
  • Hypersensitivity avoidance: do not use in individuals with known levofloxacin allergy.
  • Elderly caution: increased risk of CNS effects; monitor closely.
  • Concomitant QT‑prolonging drugs: evaluate cardiac risk before co‑administration.
  • Store at ambient temperature: keep in original packaging, protect from moisture.

Avoid Interactions

Levalox can interact with several medicines, requiring careful management.

Major Interactions (Avoid)

  • Antacids containing aluminum or magnesium: reduce levofloxacin absorption.
  • Warfarin: may increase anticoagulant effect and INR.
  • NSAIDs: heightened risk of central nervous system stimulation.

Moderate Interactions (Monitor Closely)

  • CYP1A2 inhibitors (e.g., ciprofloxacin): may increase levofloxacin plasma levels.
  • Oral contraceptives: reduced efficacy, advise backup contraception.
  • Theophylline: increased theophylline concentrations, monitor for toxicity.
  • Diabetic agents (e.g., insulin, sulfonylureas): potential for hypoglycemia, monitor glucose.

Frequently Asked Questions

Levalox contains levofloxacin, a fluoroquinolone antibiotic indicated for bacterial infections such as community‑acquired pneumonia, acute bacterial sinusitis, exacerbations of chronic bronchitis, urinary tract infections, and skin or soft‑tissue infections caused by susceptible organisms.

Levofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, enzymes required for DNA replication and transcription. By blocking these enzymes, it prevents bacterial cells from multiplying, leading to bacterial death and resolution of the infection.

The dosage of Levalox is determined by the prescribing clinician based on the specific infection, patient age, weight, renal function, and severity of disease. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Levalox is classified as a prescription‑only medication and its safety in pregnancy or lactation has not been definitively established. Healthcare providers should weigh potential benefits against risks and consider alternative therapies when appropriate.

To order Levalox, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Levalox (levofloxacin) offers broad‑spectrum activity against Gram‑positive and Gram‑negative bacteria and has a convenient once‑daily dosing schedule. Compared with older fluoroquinolones, it often provides improved tissue penetration and a lower risk of certain drug‑resistance patterns.

Levalox should be stored at ambient temperature, preferably below 25 °C. Keep the tablets in the original container, protect them from moisture and direct sunlight, and ensure they are out of reach of children.

Levalox is taken orally, usually as a tablet, with or without food as directed by the prescriber. The medication should be swallowed whole with a full glass of water and not crushed or chewed unless specifically instructed.

Serious risks include tendon rupture, especially in the Achilles tendon, QT‑interval prolongation leading to cardiac arrhythmias, severe allergic reactions such as anaphylaxis, Clostridioides difficile‑associated colitis, and peripheral neuropathy. Patients should seek immediate medical attention if they experience any of these symptoms.

Levalox should be avoided in individuals with a known hypersensitivity to levofloxacin or other fluoroquinolones, patients with a history of tendon disorders related to fluoroquinolone use, and those taking medications that significantly prolong the QT interval without close monitoring.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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