Product image of Levalox (Levofloxacin) supplied by GNH India

Levalox

Active Ingredient:
Levofloxacin
Origin:
EU

Levalox (Levofloxacin)

Levofloxacin, the active ingredient in Levalox, is a Fluoroquinolone presented as an oral dosage form for systemic use. It treats a range of bacterial infections in adults and children when prescribed by a qualified health professional.

GNH India supplies Levalox as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Krka, D.D., Novo Mesto

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Indications & Clinical Uses

  • Levofloxacin is a broad‑spectrum antibacterial indicated for several acute bacterial infections.
  • Community‑acquired pneumonia: effective treatment of susceptible bacterial pathogens causing lung infection.
  • Acute bacterial sinusitis: eradicates causative organisms to relieve sinus inflammation.
  • Acute bacterial exacerbation of chronic bronchitis: reduces bacterial load during flare‑ups.
  • Uncomplicated urinary tract infections: clears infection in the lower urinary tract.
  • Complicated urinary tract infections: targets resistant bacteria in upper or complicated UTIs.
  • Skin and soft tissue infections: combats susceptible skin‑borne bacteria.

How It Works

  • Levofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, enzymes essential for DNA replication, transcription, and repair. By blocking these targets, the drug prevents bacterial DNA supercoiling and separation, leading to inhibition of bacterial cell division and ultimately bacterial death.

Side Effects

Levofloxacin may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Nausea or upset stomach.
  • Diarrhea or loose stools.
  • Headache.
  • Dizziness.
  • Abdominal discomfort.
  • Insomnia.

Serious or Rare Side Effects

  • Tendon rupture or inflammation.
  • QT interval prolongation on ECG.
  • Severe allergic reactions such as Stevens‑Johnson syndrome.
  • Clostridioides difficile‑associated colitis.
  • Peripheral neuropathy.
  • Hepatic toxicity.

Precautions & Warnings

  • Levofloxacin should be used with caution in specific clinical situations.
  • Assess renal function: dose adjustment may be required in impaired kidney function.
  • Avoid in patients with known tendon disorders: risk of tendon rupture is increased.
  • Use cautiously in elderly patients: higher incidence of adverse events.
  • Review concomitant QT‑prolonging drugs: potential for cardiac arrhythmias.
  • Store at room temperature: keep in original packaging, protect from moisture and light.

Avoid Interactions

Levofloxacin can interact with other medicines, altering efficacy or safety.

Major Interactions (Avoid)

  • Antacids containing aluminum or magnesium: reduce levofloxacin absorption.
  • Warfarin: may increase anticoagulant effect and bleeding risk.
  • Non‑steroidal anti‑inflammatory drugs (NSAIDs): heightened risk of central nervous system stimulation.

Moderate Interactions (Monitor Closely)

  • Theophylline: may increase plasma levels, requiring monitoring.
  • Cyclosporine: potential for increased nephrotoxicity.

Frequently Asked Questions

Levalox, containing levofloxacin, is prescribed for bacterial infections such as community‑acquired pneumonia, acute bacterial sinusitis, exacerbations of chronic bronchitis, uncomplicated and complicated urinary tract infections, and skin and soft‑tissue infections caused by susceptible organisms.

Levofloxacin blocks bacterial DNA gyrase and topoisomerase IV, enzymes required for DNA replication and transcription. This inhibition prevents bacterial cells from dividing and repairing their DNA, leading to bacterial death and resolution of the infection.

The dosage of Levalox is determined by the prescribing clinician based on the specific infection, patient age, weight, renal function, and local resistance patterns. Patients should follow the prescriber’s instructions and the product label.

Safety of levofloxacin in pregnancy and lactation has not been definitively established. It is generally avoided unless the potential benefit outweighs the potential risk to the fetus or infant, and only under medical supervision.

To request Levalox, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Levalox (levofloxacin) offers a broad spectrum of activity against Gram‑positive and Gram‑negative bacteria, with once‑daily dosing for many indications. Compared with older fluoroquinolones, it often provides higher potency against respiratory pathogens and a more convenient dosing schedule, though safety considerations remain similar across the class.

Levalox should be stored at room temperature, below 25 °C, in its original container, protected from moisture and direct sunlight. Do not store in a bathroom or near heat sources to maintain product stability.

Levalox is taken orally, usually with a full glass of water. It can be taken with or without food, but patients should avoid concurrent intake of antacids containing aluminum or magnesium, as these may reduce absorption.

Serious risks include tendon rupture, especially in older adults or those on corticosteroids; QT interval prolongation leading to cardiac arrhythmias; severe hypersensitivity reactions such as Stevens‑Johnson syndrome; Clostridioides difficile‑associated colitis; and peripheral neuropathy.

Levalox is contraindicated in patients with a known hypersensitivity to levofloxacin or other fluoroquinolones, those with a history of tendon disorders related to fluoroquinolone use, and individuals taking medications that significantly prolong the QT interval without appropriate monitoring.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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