Product image of Levemir Innolet (Insulin Detemir) supplied by GNH India

Levemir Innolet

Active Ingredient:
Insulin Detemir
Origin:
EU

Levemir Innolet (Insulin Detemir)

Insulin detemir, the active ingredient in Levemir Innolet, is a long‑acting insulin analog presented as an injectable solution for subcutaneous administration. It is used to improve glycaemic control in adults and children with type 1 or type 2 diabetes mellitus.

GNH India supplies Levemir Innolet as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The product complies with EU regulatory requirements and is manufactured under GMP conditions, ensuring consistent potency and safety for patients. It is distributed through a cold‑chain logistics network to maintain stability.

Manufacturer / TM Owner

Novo Nordisk A/S

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Indications & Clinical Uses

Levemir Innolet (insulin detemir) is a long‑acting insulin analog used in the management of diabetes mellitus.

  • Type 1 diabetes mellitus: provides basal insulin to maintain fasting glucose levels.
  • Type 2 diabetes mellitus: complements oral agents or other insulin to achieve target glycaemic control.
  • Pediatric diabetes: supplies basal insulin for children who require long‑acting coverage.

How It Works

  • Insulin detemir binds to insulin receptors on muscle, adipose and hepatic cells, activating the receptor tyrosine‑kinase pathway. This promotes GLUT‑4 translocation, increasing peripheral glucose uptake, while suppressing hepatic gluconeogenesis. Its fatty‑acid side chain prolongs albumin binding, creating a flat, prolonged pharmacokinetic profile that delivers basal insulin action for up to 24 hours.

Side Effects

Levemir Innolet may be associated with several adverse reactions, ranging from mild to serious.

Common Side Effects

  • Hypoglycemia: low blood glucose episodes, especially if meals are missed or dosing is excessive.
  • Injection site reactions: redness, swelling, or itching at the injection site.
  • Weight gain: modest increase in body weight observed in some patients.
  • Lipodystrophy: localized changes in subcutaneous fat at injection sites.

Serious or Rare Side Effects

  • Allergic reactions: urticaria, angioedema, or anaphylaxis requiring immediate medical attention.
  • Edema: peripheral swelling that may indicate fluid retention.

Precautions & Warnings

When using Levemir Innolet, consider the following precautions.

  • Hypoglycemia risk: monitor blood glucose regularly and adjust dose as needed.
  • Renal impairment: use with caution; dose adjustment may be required.
  • Hepatic impairment: monitor liver function, as insulin metabolism can be altered.
  • Pregnancy and lactation: assess risk‑benefit and use only if clearly needed.
  • Drug interactions: review concomitant medications that may affect glucose levels.
  • Store at 2‑8 °C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Levemir Innolet can interact with other medicines; some require avoidance while others need close monitoring.

Major Interactions (Avoid)

  • Concurrent sulfonylureas: increased risk of severe hypoglycemia.
  • Beta‑blockers: may mask hypoglycemia symptoms.
  • Systemic corticosteroids: may reduce insulin efficacy, requiring dose increase.

Moderate Interactions (Monitor Closely)

  • Thiazide diuretics: may raise blood glucose levels.
  • ACE inhibitors: can potentiate hypoglycemia.
  • Oral contraceptives: may affect insulin requirements.

Frequently Asked Questions

Levemir Innolet contains insulin detemir, a long‑acting basal insulin. It is prescribed to improve glycaemic control in patients with type 1 or type 2 diabetes mellitus by providing a steady level of insulin throughout the day and night.

Insulin detemir binds to insulin receptors on muscle, fat and liver cells, activating intracellular pathways that increase glucose uptake and suppress hepatic glucose production. Its fatty‑acid side chain prolongs binding to albumin, giving a flat, 24‑hour insulin profile.

The dose of Levemir Innolet is individualized. A qualified prescriber determines the appropriate amount based on the patient’s age, weight, type of diabetes, current glycaemic control, and other medications. No fixed regimen is provided here.

Data on insulin detemir use during pregnancy and lactation are limited. It may be used if the potential benefit outweighs any risk to the fetus or infant. Treatment decisions should be made by a healthcare professional familiar with the patient’s condition.

To order Levemir Innolet, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, cold‑chain shipping details and necessary import documentation.

Levemir Innolet (insulin detemir) offers a relatively flat 24‑hour profile and lower intra‑patient variability compared with some older basal insulins. Compared with insulin glargine, detemir has a shorter duration in some patients, which may require twice‑daily dosing, but it is less likely to cause weight gain.

Levemir Innolet must be stored in a refrigerator at 2‑8 °C. Keep the vial in its original carton, protect it from light, and avoid freezing. Once in use, the solution can be kept at controlled room temperature (up to 30 °C) for a maximum of 28 days, as indicated on the label.

Levemir Innolet is given by subcutaneous injection, typically into the abdomen, thigh or upper arm. It should be injected into a different site each day to reduce lipodystrophy risk. The injection technique follows standard insulin administration guidelines, and patients should rotate sites systematically.

The most serious risks include severe hypoglycaemia, which can cause loss of consciousness or seizures, and allergic reactions such as anaphylaxis. Patients should be educated to recognise early signs of low blood glucose and to seek immediate medical help if a severe allergic response occurs.

Levemir Innolet is contraindicated in individuals with a known hypersensitivity to insulin detemir or any of the excipients in the formulation. It should also be avoided in patients with severe hypoglycaemia unawareness unless closely supervised by a healthcare professional.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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