Product image of Levemir Penfill (Insulin Detemir) supplied by GNH India

Levemir Penfill

Active Ingredient:
Insulin Detemir
Origin:
EU

Levemir Penfill (Insulin Detemir)

Insulin detemir, the active ingredient in Levemir Penfill, is a long‑acting insulin analog presented as a solution for injection (penfill) for subcutaneous use. It treats type 1 and type 2 diabetes mellitus in adults and children as indicated.

GNH India supplies Levemir Penfill as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Novo Nordisk A/S

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Indications & Clinical Uses

  • Levemir Penfill is a basal insulin used to manage chronic hyperglycaemia in diabetes mellitus.
  • Type 1 diabetes mellitus: provides basal insulin coverage to maintain fasting glucose levels.
  • Type 2 diabetes mellitus: adds basal insulin to oral agents for improved glycaemic control.
  • Pediatric diabetes (age ≥ 2 years): supplies long‑acting insulin needed for basal therapy in children.

How It Works

  • Insulin detemir binds to insulin receptors on peripheral tissues, stimulating glucose uptake and suppressing hepatic glucose production. Its fatty‑acid side chain promotes reversible albumin binding, creating a prolonged and steady plasma concentration that delivers basal insulin activity over 24 hours.

Side Effects

Levemir Penfill may cause adverse reactions ranging from mild to severe.

Common Side Effects

  • Hypoglycaemia: low blood glucose episodes, especially if meals are missed.
  • Injection‑site reactions: redness, swelling, or itching at the injection site.
  • Weight gain: modest increase associated with insulin therapy.
  • Lipodystrophy: localized changes in subcutaneous fat.
  • Edema: mild fluid retention.

Serious or Rare Side Effects

  • Severe hypoglycaemia: seizures or loss of consciousness.
  • Allergic reactions: rash, urticaria, or anaphylaxis.
  • Insulin antibodies: may alter insulin action.
  • Acute pancreatitis: rare but serious pancreatic inflammation.
  • Ketoacidosis: possible if insulin is abruptly discontinued.

Precautions & Warnings

  • Before using Levemir Penfill, consider the following safety measures.
  • Dose adjustment: individualise the dose based on glucose monitoring and clinical response.
  • Renal impairment: monitor renal function and adjust dose as needed.
  • Hepatic impairment: use with caution and observe for altered glucose control.
  • Pregnancy: only use if the potential benefit justifies the potential risk to the fetus.
  • Hypoglycaemia risk: educate patients on recognising and treating low blood glucose.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Levemir Penfill can interact with other medicines, affecting blood glucose levels.

Major Interactions (Avoid)

  • Concurrent sulfonylureas: increased risk of severe hypoglycaemia.
  • Beta‑blockers: may mask hypoglycaemia symptoms, complicating detection.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors: may potentiate insulin’s glucose‑lowering effect.
  • Thiazide diuretics: can raise blood glucose, requiring dose adjustment.
  • Oral contraceptives: may alter insulin requirements, necessitating closer monitoring.

Frequently Asked Questions

Levemir Penfill contains insulin detemir, a long‑acting basal insulin used to control blood glucose in people with type 1 or type 2 diabetes mellitus, providing steady insulin coverage throughout the day.

Insulin detemir binds to insulin receptors, promoting glucose uptake into cells and suppressing liver glucose production. Its fatty‑acid side chain allows reversible albumin binding, creating a prolonged, stable plasma level that delivers basal insulin activity for up to 24 hours.

The dose of Levemir Penfill is individualized. A qualified prescriber determines the amount and timing based on the patient’s blood‑glucose readings, lifestyle, and overall treatment plan.

Safety in pregnancy and lactation has not been fully established. It should only be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant, and under close medical supervision.

Submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain handling) and import documentation.

Levemir (insulin detemir) is a long‑acting insulin analog with a relatively flat 24‑hour profile, similar to glargine but with a slightly shorter duration. It offers predictable absorption and a lower risk of nocturnal hypoglycaemia compared with some older basal insulins.

Store Levemir Penfill in a refrigerator at 2‑8 °C, protected from light. Do not freeze or shake the pen. If needed, it may be kept at controlled room temperature (up to 25 °C) for a maximum of 14 days, keeping the pen upright.

Levemir Penfill is injected subcutaneously, usually once daily or twice daily, into the abdomen, thigh, or upper arm. The injection site should be rotated to minimise lipodystrophy, and the pen should be primed according to the manufacturer’s instructions before each use.

The most serious risks include severe hypoglycaemia, allergic reactions such as anaphylaxis, and the development of insulin antibodies that may affect insulin action. Patients should be educated to recognise symptoms and seek immediate medical attention if they occur.

Levemir Penfill should not be used by individuals with a known hypersensitivity to insulin detemir or any of its excipients. It is also contraindicated in patients with severe hypoglycaemia unresponsive to treatment until the underlying cause is resolved.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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