Product image of Leverette 21 (Ethinylestradiol, Levonorgestrel) supplied by GNH India

Leverette 21

Active Ingredient:
Ethinylestradiol, Levonorgestrel
Origin:
EU

Leverette 21 (Ethinylestradiol, Levonorgestrel)

Ethinylestradiol, the active ingredient in Leverette 21, is a combined oral contraceptive presented as a tablet for oral use. It works together with levonorgestrel to prevent pregnancy in women of reproductive age by inhibiting ovulation and altering cervical mucus. The formulation provides a steady hormonal dose that aligns with the monthly menstrual cycle, offering reliable contraceptive efficacy when taken as directed.

GNH India supplies Leverette 21 as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, with a focus on quality assurance and regulatory compliance.

Manufacturer / TM Owner

Exeltis Healthcare S.L

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Indications & Clinical Uses

  • Leverette 21, a combined oral contraceptive, is used within the hormonal contraceptive pathway to prevent pregnancy.
  • Prevention of pregnancy: provides reliable contraceptive protection when taken as prescribed.

How It Works

  • Ethinylestradiol and levonorgestrel act synergistically to suppress the hypothalamic‑pituitary‑ovarian axis. Ethinylestradiol provides estrogenic activity that stabilizes the endometrial lining, while levonorgestrel, a progestogen, inhibits the mid‑cycle luteinizing hormone surge, preventing follicular rupture. The combined hormonal effect also thickens cervical mucus and induces endometrial changes that reduce sperm penetration and implantation. These mechanisms together maintain contraceptive efficacy throughout the 21‑day active phase of the regimen.

Side Effects

Leverette 21 may cause a range of adverse reactions, which are generally classified by frequency and severity.

Common Side Effects

  • Nausea: mild stomach upset often occurring early in treatment.
  • Headache: transient tension or migraine‑type pain.
  • Breast tenderness: temporary swelling or discomfort.
  • Irregular bleeding: spotting or breakthrough bleeding between periods.
  • Weight gain: modest increase in body weight reported by some users.

Serious or Rare Side Effects

  • Venous thromboembolism: deep vein thrombosis or pulmonary embolism requiring immediate medical attention.
  • Hypertension: significant rise in blood pressure that may need treatment.
  • Liver disorders: jaundice or abnormal liver function tests.
  • Allergic reaction: rash, itching, or swelling that may indicate hypersensitivity.
  • Stroke: rare cerebrovascular event, especially in women with additional risk factors.

Precautions & Warnings

Before prescribing Leverette 21, clinicians should evaluate patient history and counsel on safe use.

  • Smoking status: avoid use in women over 35 who smoke due to increased thrombotic risk.
  • Cardiovascular disease: contraindicated in patients with history of myocardial infarction, stroke, or uncontrolled hypertension.
  • Migraine with aura: not recommended because of elevated stroke risk.
  • Liver disease: use with caution in patients with active liver disease.
  • Store at ambient temperature: keep below 25°C in original packaging, protect from moisture.

Avoid Interactions

Leverette 21 can interact with other medicines, altering its effectiveness or safety profile.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): may increase risk of thrombosis.
  • Enzyme inducers (e.g., rifampicin, carbamazepine): reduce hormonal levels, decreasing contraceptive efficacy.

Moderate Interactions (Monitor Closely)

  • Antiepileptics (e.g., phenytoin): may lower hormone concentrations.
  • Antiretrovirals (e.g., efavirenz): can diminish contraceptive effect.
  • Herbal supplements (e.g., St. John’s wort): may decrease oral contraceptive effectiveness.

Frequently Asked Questions

Leverette 21 is a combined oral contraceptive indicated for the prevention of pregnancy in women of reproductive age. It provides reliable birth control when taken daily according to the prescribed regimen, helping to regulate the menstrual cycle and reduce the risk of unintended conception.

Ethinylestradiol supplies the estrogen component of the combination, stabilizing the endometrial lining and contributing to the suppression of the hypothalamic‑pituitary‑ovarian axis. This estrogenic activity works together with levonorgestrel’s progestogenic effect to inhibit ovulation, thicken cervical mucus, and create an endometrial environment that is less receptive to implantation.

The exact dosing schedule for Leverette 21 is determined by the prescribing healthcare professional. Typically, combined oral contraceptives are taken once daily for 21 consecutive days followed by a hormone‑free interval, but the prescriber will set the precise regimen based on individual patient needs and clinical guidelines.

Leverette 21 is classified as Pregnancy Category X, meaning it is contraindicated in pregnancy because it may cause fetal harm. It is also not recommended during breastfeeding, as hormonal exposure could affect milk production and infant development. Women should discontinue use if they become pregnant and consult a physician before breastfeeding.

To request Leverette 21, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams worldwide. After the enquiry, the sales team will verify trade or institutional credentials, then provide pricing, availability, shipping details, and any necessary import documentation.

Leverette 21 contains the standard dose of ethinylestradiol combined with levonorgestrel, a widely used progestogen. Its efficacy, safety profile, and side‑effect spectrum are comparable to other second‑generation combined pills. Differences among products usually relate to the specific estrogen dose, progestogen type, and formulation characteristics, which may influence tolerability for individual patients.

Store Leverette 21 at ambient temperature, preferably below 25 °C. Keep the tablets in the original blister pack or container, protect them from moisture and direct sunlight, and ensure they are out of reach of children. Do not store in the bathroom or near heat sources.

Leverette 21 is taken orally, usually one tablet each day at the same time. The typical regimen involves 21 consecutive active tablets followed by a 7‑day hormone‑free interval, during which a withdrawal bleed occurs. Patients should follow the prescriber’s instructions and start a new pack immediately after the interval.

The most serious risks include venous thromboembolism (deep‑vein thrombosis or pulmonary embolism), arterial thrombosis leading to stroke or myocardial infarction, and severe hypertension. Liver disorders and rare allergic reactions can also occur. Patients should seek immediate medical attention if they experience symptoms such as unexplained leg pain, chest pain, severe headache, or jaundice.

Leverette 21 is contraindicated in women who are pregnant, have a history of thromboembolic disease, uncontrolled hypertension, active liver disease, or known hypersensitivity to any component. It should also be avoided by smokers over 35 years of age and by women with migraine with aura due to the increased risk of vascular events.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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