Product image of Leverette (Ethinylestradiol, Levonorgestrel | Lactose) supplied by GNH India

Leverette

Active Ingredient:
Ethinylestradiol, Levonorgestrel | Lactose
Origin:
EU

Leverette (Ethinylestradiol, Levonorgestrel | Lactose)

Ethinylestradiol, the active ingredient in Leverette, is a combined oral contraceptive presented as a tablet for oral use. It works together with levonorgestrel to prevent pregnancy in women of reproductive age. The formulation also includes levonorgestrel, a synthetic progestogen, providing a synergistic effect that enhances contraceptive reliability.

GNH India supplies Leverette as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and regulatory requirements across all markets.

Manufacturer / TM Owner

Exeltis Healthcare S.L

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Indications & Clinical Uses

Leverette, a combined oral contraceptive, is indicated for conditions related to reproductive hormone regulation.

  • Contraception: prevents pregnancy by inhibiting ovulation and altering cervical mucus.
  • Menstrual cycle regulation: helps achieve regular menstrual bleeding patterns.
  • Acne treatment: may improve acne associated with hormonal fluctuations.

How It Works

  • Leverette combines ethinylestradiol (an estrogen) and levonorgestrel (a progestogen) to suppress the hypothalamic‑pituitary‑ovarian axis, preventing the LH surge and ovulation. The estrogen component stabilises the endometrial lining, while the progestogen thickens cervical mucus and induces endometrial changes that reduce the likelihood of fertilisation and implantation.

Side Effects

Leverette may cause a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Breast tenderness: discomfort or swelling of the breasts.
  • Headache: occasional mild to moderate pain.
  • Breakthrough bleeding: spotting between periods.
  • Mood changes: irritability or mood swings.
  • Weight gain: slight increase in body weight.

Serious or Rare Side Effects

  • Venous thromboembolism: blood clots in deep veins.
  • Arterial thrombosis: clot formation in arteries leading to heart attack or stroke.
  • Severe hypertension: markedly elevated blood pressure.
  • Liver tumor: benign hepatic adenoma.
  • Anaphylaxis: severe allergic reaction requiring immediate medical attention.

Precautions & Warnings

When prescribing Leverette, clinicians should observe several precautionary measures to ensure patient safety.

  • Assess cardiovascular risk: evaluate history of thrombosis before initiating therapy.
  • Screen smoking status: avoid use in women over 35 who smoke.
  • Review hepatic function: adjust or avoid in patients with active liver disease.
  • Consider drug interactions: monitor concomitant use of enzyme‑inducing agents.
  • Store at ambient temperature: keep in the original pack, protect from moisture and light.

Avoid Interactions

Leverette can interact with other medicines, affecting its efficacy or safety.

Major Interactions (Avoid)

  • Antiepileptic enzyme inducers (e.g., carbamazepine, phenytoin): may reduce contraceptive effectiveness.
  • Rifampin: decreases hormone levels, increasing risk of unintended pregnancy.
  • St. John’s wort: can lower plasma concentrations of the active hormones.

Moderate Interactions (Monitor Closely)

  • Certain antibiotics (e.g., tetracycline): may slightly diminish contraceptive efficacy.
  • Antifungals (e.g., fluconazole): may increase hormone levels, raising side‑effect risk.
  • Herbal supplements (e.g., ginseng): may affect hormone metabolism and require monitoring.

Frequently Asked Questions

Leverette is a combined oral contraceptive containing ethinylestradiol and levonorgestrel, prescribed to prevent pregnancy in women of reproductive age and may also help regulate menstrual cycles and improve hormone‑related acne.

Ethinylestradiol provides estrogenic activity while levonorgestrel supplies progestogenic activity; together they suppress the hypothalamic‑pituitary‑ovarian axis, inhibit the LH surge, prevent ovulation, thicken cervical mucus and modify the endometrium, creating conditions unfavorable for fertilisation and implantation.

The specific dosing regimen for Leverette is determined by the prescribing healthcare professional and follows the standard 21‑day active tablet cycle followed by a hormone‑free interval, as indicated in the product labeling.

Leverette is contraindicated during pregnancy because it is intended to prevent conception; if pregnancy occurs, the product should be discontinued. Use during breastfeeding should be discussed with a physician, as hormonal contraceptives may affect milk production.

To request Leverette, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Leverette contains the widely used dose combination of ethinylestradiol and levonorgestrel, offering efficacy comparable to other second‑generation combined pills. Its safety profile, side‑effect spectrum and dosing schedule are similar to alternatives such as microgynon or levlen, with choice often guided by individual tolerance and risk factors.

Store Leverette tablets at ambient temperature, below 25 °C, in the original blister pack, protected from moisture, light and excessive heat. Keep out of reach of children and do not use after the expiration date.

Leverette is taken orally, usually one tablet each day at the same time, for 21 consecutive days followed by a 7‑day hormone‑free interval during which withdrawal bleeding occurs. Patients should follow the prescribing information and consult their healthcare provider for any missed doses.

The most serious risks include venous or arterial thromboembolism, myocardial infarction, stroke, and severe hypertension. Women with a history of clotting disorders, smoking over age 35, or certain cardiovascular conditions should be evaluated carefully before initiating therapy.

Leverette is contraindicated in women who are pregnant, have known or suspected breast cancer, have active liver disease, have a history of thromboembolic disorders, are over 35 and smoke, or have uncontrolled hypertension. It should also be avoided in individuals with known hypersensitivity to any component of the product.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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