Product image of Leverette (Ethinylestradiol, Levonorgestrel | Lactose) supplied by GNH India

Leverette

Active Ingredient:
Ethinylestradiol, Levonorgestrel | Lactose
Origin:
EU

Leverette (Ethinylestradiol, Levonorgestrel | Lactose)

Ethinylestradiol, the active ingredient in Leverette, is a combined oral contraceptive presented as a tablet formulation for oral use. It works together with levonorgestrel to prevent ovulation and is prescribed for women seeking reliable contraception and to regulate menstrual cycles as part of a monthly cycle regimen and provides additional benefits such as reduced menstrual bleeding.

GNH India supplies Leverette as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide with a focus on quality assurance and regulatory compliance.

Manufacturer / TM Owner

Uab Exeltis Baltics

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Indications & Clinical Uses

  • Leverette, a combined oral contraceptive, is used within the reproductive health pathway to prevent unintended pregnancy.
  • Contraception: prevents unintended pregnancy by inhibiting ovulation and altering cervical mucus.
  • Menstrual cycle regulation: helps achieve more predictable bleeding patterns and may reduce dysmenorrhea.
  • Acne management: may improve acne symptoms associated with hormonal fluctuations.

How It Works

  • Leverette contains ethynylestradiol, a synthetic estrogen, and levonorgestrel, a progestogen. Ethinylestradiol binds to estrogen receptors, providing negative feedback to the hypothalamic‑pituitary‑ovarian axis, while levonorgestrel activates progesterone receptors, suppressing the luteinizing hormone surge. The combined action inhibits follicular development, prevents ovulation, and induces changes in cervical mucus and endometrial lining, rendering the environment unsuitable for sperm penetration and implantation.

Side Effects

Leverette may cause a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Nausea
  • Headache
  • Breast tenderness
  • Spotting or breakthrough bleeding

Serious or Rare Side Effects

  • Deep vein thrombosis
  • Pulmonary embolism
  • Stroke
  • Severe allergic reaction (anaphylaxis)

Precautions & Warnings

  • Before prescribing Leverette, clinicians should consider several safety measures.
  • Pregnancy testing: confirm non‑pregnant status before initiating therapy.
  • Smoking: avoid use in women over 35 who smoke due to increased cardiovascular risk.
  • Medical history: assess for history of thromboembolic disorders, hypertension, or liver disease.
  • Medication review: evaluate concurrent use of enzyme‑inducing drugs that may reduce efficacy.
  • Store at ambient temperature: keep tablets in original container, protect from moisture and heat.

Avoid Interactions

Leverette can interact with other medicines, requiring attention to avoid reduced efficacy or increased toxicity.

Major Interactions (Avoid)

  • Strong enzyme inducers (e.g., rifampin, carbamazepine) may markedly reduce contraceptive effectiveness.
  • Concurrent use with anticoagulants may increase the risk of thrombotic events.
  • Use with other estrogen‑containing products (e.g., hormone replacement therapy) may heighten estrogen‑related adverse effects.

Moderate Interactions (Monitor Closely)

  • Antifungal agents such as ketoconazole may increase plasma levels of hormonal components.
  • Certain antibiotics (e.g., tetracycline) may slightly reduce contraceptive efficacy.
  • Herbal supplements containing St. John’s Wort may decrease effectiveness.

Frequently Asked Questions

Leverette is prescribed as a hormonal contraceptive to prevent unintended pregnancy. It works by inhibiting ovulation and altering cervical mucus, providing reliable birth control for women of reproductive age. In addition to contraception, it may help regulate menstrual cycles and reduce menstrual bleeding in some users.

The combination contains ethynylestradiol, a synthetic estrogen, and levonorgestrel, a progestogen. Ethinylestradiol provides negative feedback to the hypothalamic‑pituitary‑ovarian axis, while levonorgestrel suppresses the luteinizing hormone surge. Together they prevent follicular development, block ovulation, and cause cervical mucus to become less permeable to sperm, thereby preventing pregnancy.

The prescribing physician determines the appropriate dosing schedule for Leverette, which typically follows a daily oral regimen as indicated on the product label. Patients should take the medication exactly as directed by their healthcare provider and should not alter the dose without professional guidance.

Leverette is not intended for use during pregnancy and should be discontinued if pregnancy is confirmed. While limited data exist for breastfeeding, the hormonal components may pass into breast milk; therefore, healthcare providers usually advise caution and assess the risk‑benefit ratio before continuing therapy while nursing.

To order Leverette, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams across international markets. After the request, the sales team will verify trade or institutional credentials, then provide pricing, availability, shipping details (including any cold‑chain requirements) and assist with import documentation.

Leverette contains the standard dose range of ethynylestradiol and levonorgestrel found in many combined oral contraceptives, offering comparable efficacy in preventing pregnancy. Its safety profile aligns with other products in the class, though individual tolerability may vary. Choice among alternatives often depends on patient‑specific factors such as side‑effect preferences, cardiovascular risk, and dosing convenience.

Leverette tablets should be stored at ambient temperature, preferably below 25 °C, in the original blister pack or container to protect them from moisture and light. Keep the medication out of reach of children and do not use after the expiration date printed on the packaging.

Leverette is taken orally, usually as a single tablet each day at the same time. Patients should swallow the tablet whole with water and follow the dosing schedule prescribed by their healthcare professional, which typically involves a continuous daily regimen for the duration of the treatment cycle.

Serious risks include thromboembolic events such as deep‑vein thrombosis, pulmonary embolism, stroke, and myocardial infarction, especially in women with pre‑existing risk factors. Rare but severe allergic reactions (anaphylaxis) and significant liver dysfunction have also been reported. Patients should seek immediate medical attention if they experience symptoms like sudden chest pain, shortness of breath, or severe swelling.

Leverette is contraindicated in women who are pregnant, have a known or suspected estrogen‑dependent tumor, have a history of thromboembolic disorders, uncontrolled hypertension, severe liver disease, or are smokers over the age of 35. It should also be avoided in individuals with known hypersensitivity to any component of the tablet.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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