Product image of Leverette (Ethinylestradiol, Levonorgestrel | Lactose) supplied by GNH India

Leverette

Active Ingredient:
Ethinylestradiol, Levonorgestrel | Lactose
Origin:
EU

Leverette (Ethinylestradiol, Levonorgestrel | Lactose)

Ethinylestradiol, the active ingredient in Leverette, is a synthetic estrogen combined with levonorgestrel, a progestogen, forming a combined oral contraceptive presented as a tablet for oral use. It is indicated for prevention of pregnancy in women of reproductive age.

GNH India supplies Leverette as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to strict quality standards and provides regulatory‑approved products to meet global demand. Leverette is manufactured under EU GMP guidelines ensuring consistent potency and safety.

Manufacturer / TM Owner

Uab Exeltis Baltics

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Indications & Clinical Uses

  • Leverette, a combined oral contraceptive, acts on the hormonal regulation of the menstrual cycle to prevent pregnancy.
  • Contraception: Prevents unintended pregnancy by inhibiting ovulation and altering cervical mucus.
  • Menstrual cycle regulation: Helps control irregular periods and reduce dysmenorrhea.
  • Acne management: May improve hormonal acne in women when prescribed by a physician.

How It Works

  • Ethinylestradiol provides estrogenic activity that stabilizes the endometrium, while levonorgestrel supplies progestogenic activity that suppresses the mid‑cycle surge of luteinising hormone (LH) and follicle‑stimulating hormone (FSH). This dual action prevents ovulation, thickens cervical mucus, and renders the uterine lining less suitable for implantation.

Side Effects

Leverette may cause a range of adverse reactions.

Common Side Effects

  • Nausea or mild gastrointestinal upset.
  • Breast tenderness or enlargement.
  • Headache or migraine.
  • Spotting or breakthrough bleeding.
  • Weight fluctuation or fluid retention.
  • Mood changes or decreased libido.

Serious or Rare Side Effects

  • Venous thromboembolism (deep vein thrombosis, pulmonary embolism).
  • Arterial thrombosis (stroke, myocardial infarction).
  • Severe hypertension or hypertensive crisis.
  • Hepatic adenoma or liver dysfunction.
  • Allergic reactions including anaphylaxis.
  • Visual disturbances or severe eye pain.

Precautions & Warnings

  • Before prescribing Leverette, clinicians should evaluate individual risk factors and counsel patients accordingly.
  • Assess thromboembolic risk: Review personal and family history of clotting disorders.
  • Avoid in smokers over 35: Smoking markedly increases cardiovascular risk.
  • Monitor hepatic function: Liver disease may alter drug metabolism.
  • Consider drug interactions: Certain enzyme‑inducing agents can reduce efficacy.
  • Counsel on missed pills: Provide guidance on handling skipped doses.
  • Store at ambient temperature: Keep tablets below 25 °C in the original packaging, protected from moisture and light.

Avoid Interactions

Leverette can interact with several medications, affecting its efficacy or safety.

Major Interactions (Avoid)

  • Rifampin or other strong enzyme inducers.
  • Certain antiretrovirals (e.g., ritonavir).
  • St. John's wort herbal supplement.
  • Some anticonvulsants (e.g., carbamazepine, phenytoin).
  • Griseofulvin.

Moderate Interactions (Monitor Closely)

  • Broad‑spectrum antibiotics (e.g., tetracycline).
  • Antifungal agents (e.g., ketoconazole, itraconazole).
  • Diuretics that may affect electrolyte balance.
  • Selective serotonin reuptake inhibitors (SSRIs).
  • Certain antihypertensives (e.g., ACE inhibitors).

Frequently Asked Questions

Leverette is a combined oral contraceptive containing ethinylestradiol and levonorgestrel. It is prescribed to prevent pregnancy in women of reproductive age by inhibiting ovulation and altering cervical mucus and the endometrial lining. Under physician guidance, it may also help manage certain menstrual cycle disorders.

The ethinylestradiol component provides estrogenic activity that stabilizes the endometrium, while levonorgestrel supplies progestogenic activity that suppresses the mid‑cycle surge of luteinising hormone (LH) and follicle‑stimulating hormone (FSH). This dual action prevents ovulation, thickens cervical mucus, and makes the uterine lining less suitable for implantation.

The specific dosage regimen for Leverette is determined by the prescribing healthcare professional based on the product’s labeling and patient factors. Typically, combined oral contraceptives are taken once daily for 21 or 24 active tablets followed by a hormone‑free interval, but the exact schedule must be confirmed by the prescriber.

Leverette is intended for use only when a woman is not pregnant. If pregnancy occurs, the product should be discontinued immediately and medical advice sought. Use during breastfeeding is generally not recommended unless the benefits outweigh potential risks, and this decision should be made by a qualified clinician.

To place an order, submit an enquiry on the Leverette product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Leverette contains the standard 30 µg ethinylestradiol dose combined with 150 µg levonorgestrel, a common formulation that offers reliable contraception with a well‑characterised safety profile. Compared with products using different progestogens (e.g., desogestrel or drospirenone), Leverette may have a slightly lower risk of weight gain but similar efficacy in preventing pregnancy.

Leverette tablets should be stored at ambient temperature, preferably below 25 °C, in the original blister pack or container to protect them from moisture and light. Keep the medication out of reach of children and do not use if the packaging is damaged or the tablets appear discoloured.

Leverette is taken orally, usually with a glass of water, at the same time each day. The tablets are swallowed whole and should not be split, crushed, or chewed. Patients should follow the prescribed cycle, taking active tablets consecutively and observing any hormone‑free interval as directed by their healthcare provider.

The most serious risks include venous thromboembolism, arterial thrombosis, and severe hypertension, which can be life‑threatening. Additional rare but serious concerns are hepatic adenoma, gallbladder disease, and allergic reactions such as anaphylaxis. Patients should seek immediate medical attention if they experience unexplained leg pain, chest discomfort, severe headache, or visual changes.

Leverette is contraindicated in women with a history of thromboembolic disorders, uncontrolled hypertension, active liver disease, known or suspected breast cancer, or those who are pregnant. It should also be avoided by smokers over 35 years of age and by individuals taking medications that significantly reduce its effectiveness, unless alternative contraception is used.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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