Product image of Leverette (Ethinylestradiol, Levonorgestrel | Lactose) supplied by GNH India

Leverette

Active Ingredient:
Ethinylestradiol, Levonorgestrel | Lactose
Origin:
EU

Leverette (Ethinylestradiol, Levonorgestrel | Lactose)

Ethinylestradiol and Levonorgestrel, the active ingredients in Leverette, are combined oral contraceptives presented as a tablet for oral use. They work together to prevent pregnancy by suppressing ovulation, thickening cervical mucus, and altering the endometrium, providing reliable birth control for women of reproductive age. It is prescribed as part of a regular monthly cycle and requires daily intake.

GNH India supplies Leverette as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality and regulatory compliance.

Manufacturer / TM Owner

Exeltis Healthcare S.L

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Indications & Clinical Uses

  • Leverette, a combined oral contraceptive, is used to prevent pregnancy by acting on the hypothalamic‑pituitary‑ovarian axis.
  • Contraception: Prevents unintended pregnancy in women of reproductive age.
  • Menstrual Cycle Regulation: Provides predictable bleeding patterns and reduces menstrual irregularities.
  • Acne Management: Improves hormonal acne in women when other treatments are insufficient.

How It Works

  • Ethinylestradiol and levonorgestrel bind to estrogen and progesterone receptors, respectively, suppressing the hypothalamic release of gonadotropin‑releasing hormone. This inhibition reduces follicle‑stimulating hormone and luteinizing hormone secretion, preventing ovulation. The progestin component also thickens cervical mucus and induces endometrial changes that hinder sperm penetration and implantation.

Side Effects

Leverette may cause a range of adverse reactions, which are categorized by frequency.

Common Side Effects

  • Nausea: mild to moderate stomach upset, often transient.
  • Breast tenderness: swelling or discomfort that usually resolves with continued use.
  • Headache: intermittent pressure or throbbing pain, may respond to simple analgesics.
  • Spotting between periods: light vaginal bleeding or brown discharge.

Serious or Rare Side Effects

  • Venous thromboembolism: deep‑vein thrombosis or pulmonary embolism, requiring immediate medical attention.
  • Stroke or myocardial infarction: rare but life‑threatening cerebrovascular or cardiac events.
  • Severe allergic reaction: anaphylaxis with rash, swelling, and breathing difficulty.

Precautions & Warnings

  • Before prescribing Leverette, clinicians should consider several safety precautions.
  • Contraindicated in pregnancy: Must not be used by pregnant women.
  • Smoking over age 35: Increases risk of cardiovascular events; avoid use.
  • History of thromboembolism: Use only after thorough risk assessment.
  • Liver disease: Caution due to altered hormone metabolism.
  • Adherence: Take tablet at the same time each day to maintain efficacy.
  • Store at ambient temperature: Keep in original packaging, protect from moisture and heat.

Avoid Interactions

Leverette can interact with other medicines, affecting its effectiveness or safety.

Major Interactions (Avoid)

  • Enzyme‑inducing anticonvulsants (e.g., carbamazepine, phenytoin): reduce contraceptive efficacy.
  • Rifampin and other rifamycins: lower hormone levels, increase risk of pregnancy.
  • Protease inhibitors (e.g., ritonavir): may increase hormone concentrations and side‑effect risk.

Moderate Interactions (Monitor Closely)

  • Antibiotics such as tetracycline or fluoroquinolones: may slightly decrease effectiveness; advise backup method.
  • St. John’s Wort: herbal inducer that can lower hormone levels.
  • Diuretics and antihypertensives: may enhance risk of hypertension; monitor blood pressure.

Frequently Asked Questions

Leverette is a combined oral contraceptive indicated for the prevention of unintended pregnancy in women of reproductive age. It is also prescribed to help regulate menstrual cycles and may be used to improve hormonal acne when other treatments are insufficient.

Ethinylestradiol and levonorgestrel act on the hypothalamic‑pituitary‑ovarian axis. Ethinylestradiol provides estrogenic activity while levonorgestrel supplies progestogenic effects. Together they suppress gonadotropin‑releasing hormone, lower FSH and LH levels, prevent ovulation, thicken cervical mucus, and alter the endometrium, creating multiple barriers to fertilization and implantation.

The dosing regimen for Leverette is determined by the prescribing clinician. Typically, patients are instructed to take one tablet daily at the same time each day for a 21‑day cycle followed by a hormone‑free interval, but the exact schedule should be confirmed with a qualified healthcare professional.

Leverette is contraindicated during pregnancy and should not be started or continued by women who are pregnant. While limited data exist for breastfeeding, most guidelines advise caution; the benefits and risks should be evaluated by a healthcare provider, and alternative contraception may be recommended.

To order Leverette, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request verification of trade or institutional credentials. The sales team then provides pricing, availability, shipping details (including any cold‑chain requirements) and assists with import documentation.

Leverette contains the standard dose combination of ethinylestradiol and levonorgestrel, a widely used progestin. Its efficacy and safety profile are comparable to other COCs that use the same active ingredients. Differences among products often relate to pill formulation, estrogen dose, or additional inactive ingredients, which may affect tolerability for individual patients.

Leverette tablets should be stored at ambient temperature, below 25 °C, in the original blister pack or container. Protect them from moisture, excessive heat, and direct sunlight. Keep the medication out of reach of children and do not use tablets that appear discoloured or damaged.

Leverette is taken orally as a tablet. Swallow each tablet whole with water, preferably at the same time each day. Do not split, crush, or chew the tablet, as this could affect absorption and reduce contraceptive effectiveness.

The most serious risks include venous thromboembolism, arterial thrombosis such as stroke or myocardial infarction, and severe allergic reactions (anaphylaxis). Women with a history of clotting disorders, smoking over age 35, or certain cardiovascular conditions should be closely monitored or may need alternative contraception.

Leverette should not be used by women who are pregnant, have known or suspected breast cancer, have a history of thromboembolic disease, uncontrolled hypertension, severe liver disease, or are smokers over 35 years of age. It is also contraindicated in individuals with known hypersensitivity to any component of the tablet.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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